MYELOSUPPRESSION is a common and serious complication of the treatment of cancer because most chemotherapeutic agents lack specificity for malignant cells. A major cause of treatment-related deaths in patients with cancer is infection; the incidence of ...

GRAFTING of neuronal tissue into the mammalian brain has now become a distinct possibility for correcting the brain dysfunction of experimentally induced and genuine neurodegenerative disorders.¹ For example, chromaffin tissue from the adrenal medulla has ...

CONGENITAL nephrogenic diabetes insipidus is a rare X-linked disorder associated with renal tubular resistance to the antidiuretic hormone arginine vasopressin.¹ In affected families, 50 percent of the males are symptomatic and usually completely ...

DESPITE the availability of antiviral therapy, herpes simplex virus (HSV) infections continue to cause considerable mortality and morbidity among neonates.^{1 , 2} The incidence of neonatal HSV infections appears to be increasing as genital herpes becomes ...

THE Graduate Medical Education National Advisory Committee was the first group to predict a large surplus of physicians — some 150,000 — by the end of the century.¹ More recently, Ellwood and Tarlov have projected an even larger surplus, on the assumption ...

IN 1932, Broders defined carcinoma in situ as "a condition in which malignant epithelial cells and their progeny are found in or near positions occupied by their ancestors before the ancestors underwent malignant transformation."¹ In the breast, carcinoma ...

Presentation of Case

A 40-year-old man was admitted to the hospital because of progressive visual loss and neurologic decline.

He was well until two months earlier, when there was the onset of an unremitting bilateral retro-orbital headache, which did not ...

Experimentalists who study blood and bone marrow have long enjoyed a unique advantage: they can readily obtain those tissues and manipulate them in the laboratory to gain detailed knowledge of hematopoiesis and blood-cell function. In contrast, clinicians ...

On January 28 of this year, the Journal published the preliminary results of the Physicians' Health Study, a double-blinded, placebo-controlled trial of aspirin for the primary prevention of myocardial infarction in 22,000 apparently healthy male ...

Since publication of the 1981 report of the Graduate Medical Education National Advisory Committee (GMENAC),¹ much attention has been focused on the current and future supply of physicians in the United States. The following analysis will suggest that the ...

No extract is available for articles shorter than 400 words.

To the Editor: Two randomized trials, one in the United States¹ and one in the United Kingdom,² have evaluated prophylactic aspirin use among apparently healthy male physicians. We collaborated on these two studies, and it may be appropriate³ to consider ...

No extract is available for articles shorter than 400 words.

To the Editor: We wish to respond to the editorial of August 6.¹ Calculation of a risk–benefit ratio for Down's syndrome screening with use of maternal age and values for maternal serum alpha-fetoprotein should take into consideration the following ...

To the Editor: In recent years there has been increased concern about the appropriateness of prescribing antipsychotic medication for mentally retarded persons. This concern has arisen from the historical tendency of these medications to be used ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The subjects discussed by the distinguished contributors to this book are of great importance in medicine today, addressing some of the most vexing issues facing not only the transplantation field but all of medicine. This book developed from a conference ...

Here is a collection of 50 autobiographical accounts of illness, written by physicians. When doctors become patients, the roles and assumptions of both groups are laid bare to scrutiny. Thanks to the extraordinary courage of these physician-writers, ...

In this remarkable book, the author describes in detail his experiences as a battalion surgeon in the 88th Infantry Division, from the time of his induction in San Antonio on September 15, 1943, to the end of World War II in Italy at 6 p.m. on May 2, ...

Fascinated in medical school by the account of Carrion's self-inoculation with bartonella, the author, senior medical correspondent for The New York Times, has written the history of the men (and a few women) who chose to test a new drug, procedure, or ...

During the past two decades, the field of the history of medicine has matured. Like the physicians about whom they write, medical historians have sought to monopolize their profession through the definition of techniques and approaches that distinguish ...

A reader who goes to the shelves to learn about the history of medicine finds numerous offerings. It is clearly a popular subject. Now, a sociologist at the University of Maryland has added yet another book, partly elaborating on and expanding his earlier ...

Many books have dealt with the politics of Soviet science, but few have directly addressed the overall role of the organization that dominates that politics — the Communist party of the Soviet Union. Here, finally, Stephen Fortescue has tackled the ...

No extract is available for articles shorter than 400 words.

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the June 1982 issue of the Annals of ...