CHLOROQUINE is widely prescribed for the prevention and treatment of malaria, rheumatoid disease, and lupus erythematosus. Thus, opportunities for its accidental ingestion in children¹ and for its use in attempted suicide in adults² have increased. ...

IN Type I glycogen storage disease, glycogen accumulates in the liver, kidney, and intestine because of deficient glucose-6-phosphatase activity. Lack of glucose-6-phosphatase activity causes fasting hypoglycemia because glucose cannot be released from ...

ALTHOUGH mass vaccination against diphtheria is commonly practiced in European countries, a substantial portion of the population has antibody titers below the protective level of 0.01 IU per milliliter. It has been shown that 22 percent of the adult ...

THE efficacy of nicotine chewing gum in helping people to stop smoking has been the subject of several studies.^{1 2 3} The success rate for those who used nicotine gum was shown to be significantly higher than that for subjects given a placebo gum in five ...

OVER the past 20 years, the widespread application of cardiopulmonary resuscitation and external electrical defibrillation has permitted resuscitation of an increasing number of persons with out-of-hospital cardiac arrest. Follow-up of patients in whom ...

DURING the past century, dramatic changes have occurred in physicians' ability to prolong life. A hundred years ago, little more than rudimentary supportive care could be offered to most critically ill patients. Doctors now choose from a vast array of ...

Presentation of Case

A 22-year-old woman was admitted to the hospital because of juvenile-onset diabetes mellitus with chronic renal failure.

There was a 16-year history of diabetes that was currently managed with NPH insulin, 20 units, and regular ...

Studies of an outbreak of clinical diphtheria in Sweden serve to make two points.¹ The first involves a molecular marker of epidemiologic and possibly pathogenetic importance. The second concerns the possibility of recurrent outbreaks of diphtheria in ...

Despite the extensive literature devoted to do-not-resuscitate (DNR) orders, they continue to raise vexing problems for physicians, house staff, nurses, and policy makers. The difficulties include physicians' ambivalence about who should be consulted ...

To the Editor: Lovastatin, a new cholesterol-lowering drug that inhibits 3-hydroxy-3-methylglutaryl-CoA reductase,¹ can cause myositis and elevations in serum creatine kinase levels by means of an unknown mechanism² in a small number (<0.5 percent) of ...

To the Editor: A major factor limiting the long-term survival of patients after orthotopic cardiac transplantation is coronary-artery atherosclerosis.¹ Coronary atherosclerosis occurs at an accelerated rate in such patients as compared with persons with ...

To the Editor: A Special Report in the May 7 issue¹ by some of the members of the Immunization Practices Advisory Committee (ACIP) and staff members of the Centers for Disease Control, was not a formal statement by the ACIP. Rather, it was a discussion ...

To the Editor: Ho et al. dealt with the pathogenesis of infection with human immunodeficiency virus (HIV) in an excellent and comprehensive paper covering the main aspects of the infection (July 30 issue).¹ Some points related to the persistence of HIV, ...

To the Editor: Recently, the cloning of a candidate gene for the cystic fibrosis locus was reported.¹ DNA probes from this region identify restriction-fragment–length polymorphisms (RFLPs) that reveal strong linkage disequilibrium with the cystic ...

To the Editor: During wide experience with autografting of the adrenal medulla to the caudate nucleus in patients with Parkinson's disease,^{1 , 2} we observed a marked improvement in young patients but a high morbidity and mortality rate in elderly ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Remember the "chief complaint"? Remember your attending physician making you restate your presentation because you substituted your words for the patient's own words, to tell why he or she came to the hospital? Well, here is a textbook that doesn't forget ...

This second edition, edited by Branch and written by nearly 100 authors (most of them associated with Harvard Medical School), is simply splendid. It appears five years after the first edition, which took a problem-oriented approach to the most important ...

Physicians intending to use their personal computers to improve patient care are likely to be disappointed by the dearth of software useful in the clinic. Three recently published programs may help the busy practitioner acquire information and apply it to ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Acid–base disorders constitute a complex subject that many medical students and physicians find difficult to master. An understanding of this subject requires not only a knowledge of acid–base buffers, renal-electrolyte and pulmonary physiology, and a ...

No extract is available for articles shorter than 400 words.

SUPERCOMPUTING WORKSHOP AND TIME GRANTS

The workshop will be offered in Pittsburgh, Feb. 22–26. The application deadline is Jan. 15. Grants of computer time for biomedical research are also being offered.

Contact Wendy Janocha, Pittsburgh Supercomputing ...

The struggle to achieve equal rights for American blacks has included legal and social pressure to provide access to jobs, housing, education, the ballot box, theaters, buses, hotels, and restaurants. Within the medical establishment, there has been a ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the June 1982 issue of the Annals of ...