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August 27, 1987  Vol. 317 No. 9

Original Articles
521-526

    THE search for risk factors for stroke was begun later than studies of risk factors for coronary heart disease. In the early 1970s, it was demonstrated in the Framingham study1 and the Evans County study2 that hypertension was a powerful risk factor for ...

    526-532

    MYELOMA is characterized by extensive bone destruction, which occurs in almost all patients and is accompanied by severe and intractable pain and susceptibility to fracture. Hypercalcemia develops in many patients during the course of the disease.1 ...

    532-536

      A RECENT National Institutes of Health conference on osteoporosis recommended a calcium intake of 1000 to 1500 mg per day to reduce the incidence of osteoporosis in postmenopausal women. Since about 50 percent of U.S. women between the ages of 18 and 70 ...

      537-541

      THE physiologic role of calcitonin in human beings is unknown, despite intense research since the hormone was discovered in 1960.1 Recent theories have centered on the possibilities that calcitonin regulates osteoclastic bone resorption2 and that a long-...

      Mechanisms of Disease
      542-549

      When lysosomes were first characterized biochemically by de Duve and his colleagues,1 the low optimal pH of their degradative enzymes suggested that their internal environment was acidic. Because material taken up by phagocytosis was known to enter an ...

      Special Article
      550-556

        THE past several years have seen the implementation of diverse regulatory and financing changes aimed at reducing governmental costs for the health care of the poor and the elderly.1 , 2 In the Medicaid program, a variety of cost-limiting initiatives (...

        Case Records of the Massachusetts General Hospital
        556-564

        Presentation of Case

        A 21-year-old woman was admitted to the hospital because of a mass in the right hepatic lobe.

        The patient's menarche began at the age of 16 years, with flow that lasted two or three days and was not preceded by molimina. At the age of ...

        Sounding Board
        565-567

          Relatively few medical investigators have used the patent process to protect proprietary rights to their work, choosing instead simply to publish their results. The patent system was established by the Constitution two centuries ago. Article 1, Section 8, ...

          567-569

          The annual meeting of the Association of Professors of Medicine, an organization of the chairpersons of the departments of medicine of our nation's 125 medical schools, was held last May. Much of the discussion at the meeting was about what has become ...

          Correspondence
          569-570

          No extract is available for articles shorter than 400 words.

          570-571

          No extract is available for articles shorter than 400 words.

          572

          No extract is available for articles shorter than 400 words.

          572-573

          To the Editor: Deray et al. reported digitalis-like substances in patients with active acromegaly.1 We have measured sodium efflux in the leukocytes of normal volunteers and of patients with active and treated acromegaly.2 The leukocytes were isolated ...

          573-574

          To the Editor: The hypereosinophilic syndrome is a multisystem disease characterized by marked eosinophilia of the peripheral blood and bone marrow and by diffuse infiltration of organs with these cells.1 The average duration of survival of nine months2 ...

          574-575

          No extract is available for articles shorter than 400 words.

          575

          No extract is available for articles shorter than 400 words.

          575-577

          No extract is available for articles shorter than 400 words.

          Book Reviews
          577

          Family members caring for persons with dementia face emotional, physical, financial, and ethical challenges that can disrupt their own lives. Physicians caring for these patients have a duty to assist these families by diagnosing the condition accurately, ...

          577

          Thomas Szasz, a practicing psychoanalyst, is widely known as the leading opponent of the medical model in psychiatry and as the originator of the contention that mental illness is a myth. In his writings over the past 30 years he has challenged ...

          577-578

          The past 30 years have witnessed a remarkable increase in our knowledge of the function of the nervous system, both normal and abnormal, as a casual glance at recent programs of the Society for Neuroscience will attest. Inevitably, this research will have ...

          578

          No extract is available for articles shorter than 400 words.

          578-579

          The idea of giftedness is one that has compelled interest throughout the ages. Stories of the young Mozart playing and composing symphonies or of a youthful math prodigy have the ability to dazzle the imagination of most. This collection of current ...

          579

          The series in which this book is the third publication reviews topics of child mental health within the general framework of child development. This framework emphasizes the interaction between biologic maturation and environmental experiences. The stated ...

          579-580

          No extract is available for articles shorter than 400 words.

          Notices
          580

          THORACIC AND CARDIOVASCULAR SURGERY

          The 8th Asian Congress will be held in Raffles City, Singapore, Oct. 30–Nov. 3.

          Contact the Secretariat, Acad. of Med., Singapore Coll. of Med. Bldg., College Rd., Singapore 0316; or call 2238968.

          BREAST CANCER ...

          Correction
          580

          No extract is available for articles shorter than 400 words.

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