RECENT advances in understanding the biology and therapy of acute lymphoblastic leukemia have had a considerable effect on survival in this heterogeneous group of diseases; long-term disease-free survival rates of 50 to 75 percent are now observed in ...

IN the studies described here, we used X-chromosome inactivation mosaicism to trace the development and cell-lineage relations of acute nonlymphocytic leukemia. The cell "marker" we employed is the X-chromosome–linked enzyme glucose-6-phosphate ...

VAGINAL spermicides are a popular form of contraception, particularly because of concerns about the safety of other forms of contraception, such as oral contraceptives^{1 , 2} and intrauterine devices.³ However, the safety of spermicides has been brought ...

THERE has been recent interest in the possibility that the use of spermicidal contraceptives, historically considered among the safest of the reliable methods of contraception, might raise the risk of certain congenital anomalies, including Down's ...

IN 1971 McCarthy and Pepys¹ described both an immediate and a delayed asthmatic response to an inhaled extract of Aspergillus fumigatus. This biphasic asthmatic reaction was subsequently shown to occur after exposure to dust, pollen, or red cedar extract ...

TEN years ago, in September 1977, the National Institutes of Health (NIH) launched its Consensus Development Program by convening a conference on screening for breast cancer.¹ This effort initiated a decade of increasing interest in technology assessment ...

UNDERSTANDING the success or failure of transplantation of an allograft involves consideration of the antigens on the transplanted tissue that are recognized by the recipient as foreign and that can evoke the rejection response, the cells in the recipient'...

Presentation of Case

A 30-year-old woman was admitted to the hospital because of increasing ataxia.

She was born at 39 weeks of gestation after an uncomplicated pregnancy of a mother 44 years old who used no tobacco, alcohol, or medications; the cord was ...

Exercise is one of many nonpharmacologic and nonimmunologic stimuli that can produce acute episodes of airway obstruction in patients with asthma. Unlike other types of provocations that function only periodically in the lives of patients with the disease,...

The tale of poor countries squandering resources on high-technology medicine is by now too familiar: the hospital in the capital city consuming 90 percent of the health budget while the countryside lacks safe water; the CT scanner perched virtually atop a ...

To the Editor: Hearst et al. (March 6, 1986, issue)¹ have conducted an interesting study of subsequent mortality among men who were eligible for the draft in the early 1970s and men who were exempt. Their chief finding was of excess mortality from motor-...

To the Editor: For the sake of accuracy and clarity, I would like to make a few observations on the article by Veasy et al. on rheumatic fever (Feb. 19 issue).¹ First, the authors state that the patients met the modified Jones criteria,² but they cite ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Chickenpox caused by infection with varicella–zoster virus is a common childhood disease. It is generally accepted that the original infection confers lifelong protection against reinfection with the virus. We report an apparent case of ...

No extract is available for articles shorter than 400 words.

Is there a competitor you wish to immobilize or friends you want to entrance? Give them this encyclopedia. I had a wonderful time reading these two volumes, but I must confess that it was difficult to get other work done. The editors clearly enjoyed ...

The anatomical atlas is an invaluable aid for visualizing the spatial relations between structures. A complete and functional atlas is therefore a key to the efficient use of dissection and study time. This is particularly important in the face of the ...

No extract is available for articles shorter than 400 words.

Learning the physical examination — along with dissecting the first cadaver and doing the first clinical clerkship — is a seminal event for medical students. Perhaps its power, like that of dissection, resides in performing otherwise prohibited actions, ...

No extract is available for articles shorter than 400 words.

The medical–industrial complex is a dynamic and complex enterprise that requires effective physician–executive leaders at all levels — from solo and group practices to multisystem national health care corporations. This book addresses itself to clinicians ...

This book is an abridged version (approximately two thirds the length) of Professor Guyton's Textbook of Medical Physiology (7th ed. Philadelphia: W.B. Saunders, 1986). Its stated objective is to provide college, medical, and professional school students ...

Biomedical Science

Advances in Chronobiology. (Progress in Clinical and Biological Research. Vol. 227.) Edited by John E. Pauly and Lawrence E. Scheving. Part A, 528 pp., illustrated; Part B, 613 pp., illustrated. New York, Alan R. Liss, 1987. $130 per ...

JUVENILE DIABETES FOUNDATION AWARDS

Applications are now being accepted for the following awards: "Career Development Award in Diabetes Research" (Oct. 1 deadline); "Postdoctoral Fellowships in Diabetes Research" (Oct. 1 deadline); and "New Training for ...