DISTURBANCES in the function of several organ systems frequently develop in patients requiring intensive medical care. This syndrome of multipleorgan failure often occurs during the course of acute respiratory failure,^{1 , 2} particularly in the presence of ...

THE existence of substrate cycles was proposed approximately 20 years ago.¹ A substrate cycle may exist when opposing, nonequilibrium reactions catalyzed by different enzymes are active simultaneously. One example of a substrate cycle is the simultaneous ...

COP 1 is synthesized by the random polymerization of L-alanine, L-glutamic acid, L,-lysine, and L-tyrosine in the ratio of 6.0:1.9:4.7:1.0 (molecular weight, 14,000 to 23,000). It was one of a series of polypeptides prepared to simulate myelin basic ...

CLINICAL and experimental evidence suggests that stimulation of fetal hemoglobin production will benefit patients with sickle cell anemia by inhibiting sickling. In adults, fetal hemoglobin appears to be restricted to a subpopulation of red cells, the F ...

IN patients with diabetic autonomic neuropathy^{1 , 2} or autonomic neuropathies of other origins,^{3 , 4} vascular sensitivity to alpha-adrenergic agonists such as norepinephrine is increased. This effect may be due to denervation hypersensitivity following ...

OVER the years there has been a steady improvement in the clinical testing of new treatments. The randomized, controlled clinical trial has been increasingly accepted, along with higher standards in various aspects of trial design. We now have more ...

Presentation of Case

A 46-year-old man was admitted to the hospital because of pain in the right lower abdominal quadrant.

He was well until 9 or 10 days earlier, when fever and intermittent severe periumbilical pain developed, lasted for a day or two, ...

Multiple sclerosis is an inflammatory disease of the central nervous system in which infiltrating lymphocytes (predominantly T cells) and macrophages lead to degradation of the myelin sheath. The leading hypothesis about the causation of multiple ...

Five years ago, an unfortunate baby with Down's syndrome and esophageal atresia was allowed to die of starvation in Indiana.¹ His death, coming 10 years after the Supreme Court decision that legalized abortion and 2 years into the Reagan administration, ...

After several decades of experience with methadone maintenance treatment for narcotic addiction, given to well over 100,000 patients throughout the world, there continue to be widely divergent views about its effectiveness. To a large extent, this is the ...

To the Editor: The acquired immunodeficiency syndrome (AIDS) was recognized for the first time in Africans soon after its appearance in the United States.^{1 , 2} The origin of AIDS remains enigmatic and controversial. Several investigators^{1 2 3 4} have ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Both these books deal with pulmonary pathophysiology, but they differ considerably in scope and approach. The first, edited by Hodgkin and Petty, deals specifically with chronic obstructive pulmonary disease (COPD). Twenty-four experts have contributed ...

Although research in pulmonary diseases is using the tools of molecular and cellular biology (in sarcoidosis and acute respiratory distress syndrome) and genetic engineering (in alpha₁ antiprotease-deficiency emphysema, lung cancer, and cystic fibrosis), ...

No extract is available for articles shorter than 400 words.

Both the clinical and basic aspects of oncology are changing at such a rapid pace that both newcomers and veterans may sometimes be bewildered by the explosion of new information. Clinical cancer management changes monthly, making it difficult to keep ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This updated version of the Cancer Manual of the American Cancer Society (Massachusetts Division) provides a convenient and comprehensive yet succinct summary of most aspects of clinical cancer management. The editors have enlisted the participation of ...

No extract is available for articles shorter than 400 words.

SACRED HEART HOSPITAL

The following courses will be offered: "The Fourth Annual Labor Day Pediatric Symposium on Acute Care" (Sept. 4–6); and "The 13th Annual Gulf Coast Internal Medicine Conference" (Oct. 23 and 24).

Contact Dr. Garth Grove, Sacred Heart ...