MORBIDITY and mortality due to acute myocardial infarction depend primarily on the size of the infarct and its correlate, residual left ventricular function. Although the treatment of acute myocardial infarction with intravenous streptokinase is ...

BONE marrow transplantation has been increasingly used as potentially curative therapy in children with refractory forms of acute leukemia.^{1 2 3 4 5} These forms include acute myelogenous leukemia (AML), in which historically the long-term disease-free ...

SULFASALAZINE, the most commonly used drug for ulcerative colitis, is effective both to induce remission of mildly to moderately active disease^{1 2 3} and for long-term maintenance therapy.^{4 , 5} However, up to one third of patients who take sulfasalazine ...

THE diagnosis of post-traumatic stress disorder was added to the American psychiatric nomenclature with the publication in 1980 of the third edition of the official manual of the American Psychiatric Association, the Diagnostic and Statistical Manual of ...

THE organization of community care for patients with the most severe chronic mental illnesses is seriously deficient. Most of these patients depend exclusively on underfinanced, fragmented, and often inaccessible public services. The difficulties of ...

PROTEIN C is a vitamin K-dependent anticoagulant protein that inactivates the coagulation cofactors Va and VIIIa in a reaction that is enhanced by phospholipid and protein S.^{1 2 3} In order for protein C to serve as an anticoagulant, it must be activated ...

HUMAN immunodeficiency virus (HIV) is the etiologic agent of the acquired immunodeficiency syndrome (AIDS).^{1 2 3 4} HIV penetrates specific cells bearing the CD4 surface antigen^{5 , 6} and has been observed in helper T lymphocytes, monocytes, Langerhans' ...

Presentation of Case

A 20-year-old woman was admitted to the hospital because of a diagnosis of central Cushing's disease.

She was well until a year and a half earlier, when hypertension developed in the third trimester of pregnancy and was managed by ...

The recent approval by the Food and Drug Administration of tissue plasminogen activator (t-PA) for clot lysis and preservation of myocardial function in patients with acute myocardial infarction has highlighted the potential importance of thrombolytic ...

During the 1960s and 1970s, custodial care for the severely mentally ill in large state hospitals was abandoned and replaced by care in the community. Four influences lay behind this shift.

The first was the introduction of the phenothiazine drugs into ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Several research groups have reported the prognostic importance of blast-cell chromosome number (ploidy) in children treated for acute lymphoblastic leukemia, emphasizing the favorable outcome associated with a karyotype of more than 50 ...

To the Editor: There are several case reports describing patients with acute leukemia who received cytotoxic drugs during pregnancy and gave birth to normal children.^{1 , 2} There is one report of a fetal group C trisomy after cytarabine therapy.³ Here, we ...

To the Editor: Elevations of platelet counts have been observed after injection of IgG anti-D into Rh-positive adults¹ and children² with idiopathic thrombocytopenic purpura. We investigated the effectiveness of anti-D in an Rh-positive adult with ...

To the Editor: A recent Case Record in the Journal (July 9 issue)¹ mentioned a few inherited causes of aortic-root disease, a well-known feature of Marfan's syndrome that has now been recognized in Turner's syndrome.² We report a case of mild aortic ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The first of these two books is a lively and insightful exposition of current problems in health services, set in the context of a hospital-oriented history of medical care and the evolving role of U.S. hospitals from the 1930s to the late 1980s. The ...

No extract is available for articles shorter than 400 words.

Much recent writing in bioethics is directed not at the clinician but at the health care manager. Discussions of truth-telling, informed consent, human experimentation, and euthanasia — the bread and butter of bioethics during the 1960s and early 1970s — ...

When I plopped this yellow-jacketed book on my desk, I thought, "Oh, no — not another heal-thyself compendium of trend medicine for mass consumption." Reading it cover to cover, I was pleased to find that it is a readable guide to a healthy life. It is ...

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OCCUPATIONAL HEALTH AND SAFETY

The following programs will be offered in St. ...

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Death rates among hospitalized patients have increasingly been used to compare hospitals and set policy. Some authors have used them to argue for regionalization of procedures, citing data indicating that hospitals performing a large number of a specified ...