THE myelodysplastic syndromes are a group of stem-cell disorders characterized by maturation defects resulting in ineffective hematopoiesis, refractory cytopenias often leading to infection or hemorrhage, and an increased risk of leukemic transformation.¹ ...

IN 1938, at a meeting of the St. Louis Medical Society, Dr. Michael Somogyi¹ stated: [W]e obtained evidence to the effect, that the extreme fluctuations in the blood sugar level, and the progressively increasing unstability of diabetic patients, are the ...

THERE is substantial evidence that both congenital and acquired asplenia confer a risk of fulminant and often fatal bacterial sepsis even in otherwise healthy persons.¹ Overwhelming infection may occur days to years after removal of the spleen; it begins ...

THE 60 to 70 percent mortality rate associated with the adult respiratory distress syndrome (ARDS) has not improved since the syndrome was first described in 1967, despite improvements in supportive therapy.^{1 2 3 4 5} Diffuse lung inflammation is typical ...

CREUTZFELDT–JAKOB disease (CJD), kuru, and the Gerstmann–Sträussler syndrome are human neurodegenerative diseases that can be transmitted experimentally to animals. In 1920, Creutzfeldt described a progressive dementing illness in a 22-year-old woman. The ...

CARCINOMAS have been associated with such paraneoplastic syndromes as skin-tumor growth, ectopic hormone production, arthropathies, myopathies, neuropathies, multiple thromboses, nephrosis, cachexia, and disseminated intravascular coagulation.¹ Cutaneous ...

Presentation of Case

A 51-year-old woman was admitted to the hospital because of progressive abdominal distention.

She was well until 12 years earlier, when hypothyroidism and pernicious anemia were found; vitamin B12 and levothyroxine were begun. Seven ...

An important landmark in our conception of viruses was the recognition that viruses can cause diseases that present none of the hallmarks of classic infectious diseases. Perhaps the most extraordinary example of this atypical behavior of "viruses" is ...

The protean manifestations of cancer can be classified on a pathophysiologic basis into direct and indirect effects. The direct effects of primary and metastatic cancers are the result of invasive masses interfering with the normal functioning of organ ...

No extract is available for articles shorter than 400 words.

To the Editor: Nemaline (rod) myopathy of adult onset is a slowly progressive neuromuscular disease usually presenting in the fifth to sixth decades of life.^{1 2 3} Its mechanism and cause are unknown, and no therapy is available. We report a case of a ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Managing cerebral vascular disease is like walking through quicksand: one may have a general plan for dealing with the problem, but invariably there are spots where the more solid ground gives way, and further progress is made only by the most careful and ...

The professional and lay public alike have a dreary picture of chronic mental illnesses. This is due in part to the poor grooming and bizarre behavior characteristic of the disability phase of these conditions, as well as to the anxiety that most people (...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Our first book here is specifically designed for professionals who work in a general hospital setting. It is a multiauthored work focusing on the problems of patients with symptoms that overlap the disciplines of psychiatry and neurology. The editors have ...

No extract is available for articles shorter than 400 words.

Biomedical Science

Advances in Cancer Research. Vol. 48. Edited by George Klein and Sidney Weinhouse. 373 pp., illustrated. Orlando, Fla., Academic Press, 1987. $65.

Bacterial Protein Toxins. (Second European Workshop, Wépion, June 30–July 4, 1985.) (...

PLASTIC SURGERY EDUCATIONAL SYMPOSIA

The following symposia will be offered: "Secondary Surgery and Management of the Unfavorable Result" (Monterey, Calif., Jan. 14–17); and "The Fundamentals of Plastic Surgery — The Basics in Perspective" (Snowbird, Utah,...