IN 1979, after injecting crude extracts of human prostatic tissue into rabbits, Wang et al. isolated and purified a glycoprotein specific for prostatic epithelial cells.¹ Simultaneously and independently, Graves et al., using acrylamide gels, isolated and ...

THE epidemiologic evidence linking squamous-cell carcinomas of the uterine cervix to one or more venereally transmitted agents^{1 2 3 4 5} has recently been substantiated by the discovery that certain types of human papillomaviruses (types 16, 18, 31, and 33)...

HAEMOPHILUS influenzae type b (Hib) is an important cause of serious infections in infants and children.^{1 2 3} In the United States the highest attack rates of meningitis and other bacteremic infections due to Hib have been documented among certain ...

DESPITE recent advances in our understanding of the molecular mechanisms that give rise to malignant behavior of cells, the role of known oncogenes in human cancer remains largely conjectural.¹ Oncogenes are derived from normal genes ("proto-oncogenes") ...

SPOROTRICHOSIS typically presents as a chronic infection involving all the layers of the skin and the subcutaneous lymphatics, producing an indolent lesion that may remain localized or spread centrally through the local lymphatics, establishing a chain of ...

LYMPHOKINES are polypeptide products of activated lymphocytes that participate in a variety of cellular responses, including the regulation of the immune system. They are released in response to antigen, but in contrast to the chemical composition of ...

Presentation of Case

A 27-year-old woman with past idiopathic thrombocytopenic purpura was admitted to the hospital because of headache, recurrent thrombocytopenia, and a question of intracranial hemorrhage.

She was well until nine years earlier, when ...

After half a century of clinical application, the usefulness of prostatic acid phosphatase (PAP) as a marker for carcinoma of the prostate is being challenged. Historically the first of the "serum markers" for the presence of a human cancer,¹ acid ...

The idea that specific genes or groups of genes are responsible for the induction or maintenance of cancer is by no means new. Recent research efforts to understand such genetic sequences have focused on the study of cellular oncogenes or proto-oncogenes. ...

The paper by Scott et al. in this issue of the Journal describes the use of antibody detection in cerebrospinal fluid in the diagnosis of seven cases of meningeal sporotrichosis.¹ Diagnosis of this form of chronic meningitis is challenging because of the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In their progress report in the April 9 issue, Rosenberg et al.¹ stated that adoptive immunotherapy with LAK (lymphokine-activated killer) cells plus interleukin-2 can result in tumor regression in some patients for whom no other therapy ...

To the Editor: Recent studies have shown that blood monocytes become activated during regular hemodialysis and produce interleukin-1.^{1 2 3} Monocyte products such as interleukin-1 are thought to contribute to both the short-term and long-term changes that ...

No extract is available for articles shorter than 400 words.

To the Editor: Intravascular volume expansion to prevent intracranial arterial spasm is a well-established treatment for intracranial hemorrhage.^{1 2 3} The use of hetastarch (hydroxyethyl starch) to expand plasma volume is now a common practice in ...

No extract is available for articles shorter than 400 words.

To the Editor: Renlund and colleagues raise some very important questions and provide some valid criticisms of the Medicare designation of cardiac transplantation centers (April 2 issue).¹ It is indeed important to recognize that the National Heart ...

To the Editor: We describe a hazard to small children — the motorized parking gate. Such gates, opened by plastic "key cards," secure the parking lots of an increasing number of housing complexes, but as the following case report suggests, they are ...

No extract is available for articles shorter than 400 words.

The task of reviewing two textbooks of more than 2000 pages each, covering the entire range of internal medicine, is awesome. While I was in the throes of deciding how to grapple with this herculean task, the last words of Gertrude Stein came to mind: "...

Medicine changes rapidly. Textbooks follow and try to catch up. A profound change in internal medicine has been its molding into what is termed general medicine, and the growth of primary care. Medical textbooks have tried to keep pace with these changes ...

This book is an excellent overview of research by the National Aeronautics and Space Administration (NASA) and related literature on the inactivity, exercise conditioning, weightlessness, and a sedentary life style. It presents the directions of thought ...

Discussion of the ethics of human experimentation has become a bore to some ethicists and members of institutional review boards (IRBs). It was the first issue to receive intensive scrutiny when medical ethics became a growth industry about 20 years ago, ...

The author of this book is well known in medical ethics. His Case Studies in Medical Ethics (Cambridge, Mass.: Harvard University Press, 1977) and A Theory of Medical Ethics (New York: Basic Books, 1981) and his many articles have shown how important and ...

Within the medical and allied health professions, and the health care "industry" in general, there is perhaps general agreement that in past years, those in nursing homes have not enjoyed full patient–citizen status. Nursing homes blossomed two or three ...

INTERNATIONAL CONGRESS ON CYCLOSPORINE

The congress will be held in Washington, D.C., Nov. 4–7.

Contact Linda Brown, Univ. of Texas Medical School at Houston, Office of Cont. Educ., 6431 Fannin St., MSB G.104, Houston, TX 77030; or call (713) 792–5346.

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No extract is available for articles shorter than 400 words.