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September 17, 1987  Vol. 317 No. 12

Original Articles
717-722

HAEMOPHILUS INFLUENZAE type b is a primary cause of life-threatening invasive infections in young children. About 18,000 cases, of which 900 to 1200 are fatal, are estimated to occur yearly in the United States among children less than five years of age.1 ...

722-728

THE widely prescribed triazolobenzodiazepine derivative triazolam1 , 2 is representative of a newer class of benzodiazepine derivatives that have short elimination half-lives.3 , 4 Triazolam's elimination half-life in healthy humans averages 2 to 5 hours5 ...

728-733

THE fall in hemoglobin concentration observed during the first few months of life represents physiologic adaptation to the extrauterine environment.1 , 2 In term infants, hemoglobin concentrations reach a nadir of 10 to 11 g per deciliter between two and ...

734-737

THE examination of mutant human genes at a molecular level has revealed that inherited diseases are usually heterogeneous. Each disease can be produced by any of several mutations in a single gene or in a related set of genes. Heterogeneity of mutations ...

738-742

SENILE cardiac amyloid is a frequent postmortem finding in patients more than 80 years of age and has generally been regarded as nonspecific and of no functional importance.1 In contrast, clinically important amyloid deposition in the heart has been ...

Special Articles
743-748

    Despite the substantial decline in infant mortality that has occurred in the United States since the early 1960s, black infants remain twice as likely as white infants to die during their first year of life.1 There is even some evidence to suggest that ...

    749-753

      ALTHOUGH the infant mortality rate in the United States has declined rapidly over the past two decades, the rate among blacks remains nearly twice as high as that among whites. Much of the excess mortality among blacks is due to their lower birth weights. ...

      Case Records of the Massachusetts General Hospital
      754-762

      Presentation of Case

      A 22-year-old woman was admitted to the hospital because of severe headaches.

      She was well until 11 months earlier, when she awoke with nuchal pain that radiated intermittently to either arm and sometimes to the second and third ...

      Editorial
      763-765

      Approximately 245,000 low-birth-weight infants were born in the United States in 1986. These infants account for the majority of deaths in the first year of life, and they have a significantly increased risk of permanent disability.1 Low birth weight is ...

      Sounding Board
      765-766

      The most important phase in the training of internists is the period spent as interns and residents. The outstanding places for such training have been the university medical centers. During the past decade, however, the clinical character of the patients ...

      Massachusetts Medical Society
      766

      No extract is available for articles shorter than 400 words.

      Correspondence
      766-768

      No extract is available for articles shorter than 400 words.

      768-769

      To the Editor: We believe that the paper by Vadheim et al. (Nov. 20 issue)* on preferential transmission of diabetic alleles in insulin-dependent diabetes mellitus (IDDM) contains a fundamental flaw in its design, which invalidates the use of the data. ...

      769-770

      No extract is available for articles shorter than 400 words.

      770

      No extract is available for articles shorter than 400 words.

      770-771

      No extract is available for articles shorter than 400 words.

      771-772

      To the Editor: Chymopapain chemonucleolysis1 of herniated lumbar disks has become less popular because of some anaphylactic reactions, including death, leakage of enzyme and consequent neurologic defects, subarachnoid hemorrhage, and unexplained ...

      772

      No extract is available for articles shorter than 400 words.

      772

      No extract is available for articles shorter than 400 words.

      772-773

      To the Editor: It has been suggested that patients with blood-Group B antigen are poor candidates for cardiac transplantation.1 An analysis of survival among patients receiving cardiac transplants at Johns Hopkins Hospital between July 1983 and February ...

      774

      No extract is available for articles shorter than 400 words.

      Book Reviews
      774

      The problem with reform of the medical malpractice system is not an absence of good ideas; there exists a smorgasbord of intelligent, worthy proposals for addressing a situation that for the medical profession and society is at best a problem and at worst ...

      774-775

      The number of elderly persons is increasing, and the elderly use a disproportionate quantity of medical services. In addition to being seen in the usual office and hospital settings, elderly patients are seen at home and in nursing homes. Several diseases ...

      775

      No extract is available for articles shorter than 400 words.

      775

      No extract is available for articles shorter than 400 words.

      775

      No extract is available for articles shorter than 400 words.

      776

      The addition of this book to the wealth of recent textbooks on dermatologic therapy is good evidence of the difficulty experienced in treating chronic skin diseases. Four of the most prominent competing works are Current Dermatologic Therapy (Madden S, ...

      776

      This is a large book, which is mistitled because it deals solely with iatrogenesis related to drugs. There are many physician-generated diseases not related to drugs. Iatrogenic diseases occur as a result of accidents, errors in physician judgment, ...

      Books Received
      776-779

      Biomedical Science

      Advanced Magnetic Resonance Techniques in Systems of High Molecular Complexity. (Progress in Inorganic Biochemistry and Biophysics. Vol. 2.) Edited by Neri Niccolai and Gianni Valensin. 515 pp., illustrated. Boston, Birkhäuser, 1986. $...

      Notices
      780

      PSEF INTERNATIONAL TISSUE EXPANSION SYMPOSIUM

      The symposium will be held in San Francisco, Oct. 7–10.

      Contact Plastic Surgery Educational Fdn., 233 N. Michigan Ave., Suite 1900, Chicago, IL 60601; or call (312) 856–1818.

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