SEPSIS can be defined as the systemic response to infection and has been estimated to occur in 70,000 to 300,000 patients in the United States each year.^{1 , 2} Hypotension is present in approximately 40 percent of these patients and has been shown to ...

DESPITE steady improvements in antibiotic therapy and intensive care during the past decade, mortality from fulminant sepsis has remained close to 50 percent.^{1 , 2} This high mortality rate has continued to stimulate interest in pharmacologic agents that ...

IN 1886 Reginald Fitz gave his historic lecture describing the new pathological entity appendicitis. After 100 years, the diagnosis of this simple disease remains a problem. Whereas mortality and morbidity from appendicitis have decreased tremendously in ...

ATRIAL fibrillation may occur in the presence of a variety of cardiovascular diseases but also in the absence of any other clinical evidence to suggest a primary cardiac disorder; in the latter case it is known as lone atrial fibrillation.¹ The influence ...

ERYTHROCYTES infected with plasmodia lose deformability and become susceptible to filtration by the spleen.^{1 , 2} A role for splenic filtration in antimalarial host defense is suggested by the deleterious effects of splenectomy,³ the apparent requirement ...

THIS article summarizes the current status of research on refining case-mix adjustment, which is the process of adjusting for differences in hospital cases in order to allow comparisons of costs and outcomes among cases and hospitals. Case-mix adjustment ...

HUMAN neutrophilic polymorphonuclear leukocytes (neutrophils) provide an effective host defense against bacterial and fungal infection, but they are also important in the pathogenesis of tissue damage in certain noninfectious diseases. Some important ...

Presentation of Case

A 50-year-old man was admitted to the hospital because of bilateral pneumonia and respiratory failure.

He was well until two weeks previously, in early October, when coryza, a nonproductive cough, and myalgia developed and subsided ...

The article by Puylaert et al. in this issue of the Journal ¹ concludes that "ultrasonography is a useful aid in the diagnosis of appendicitis" — probably an acceptable summation, provided that it is not interpreted as advocating use of ultrasound studies ...

In this issue of the Journal, Looareesuwan et al. describe alterations in the function of the spleen in the course of malaria.¹ Such a report could not have been written until quite recently, because although the spleen was known to the ancients, its ...

Judged in many ways, the American health care system is remarkable. An enormous, diversified, and complex apparatus, it employs more than 6 million people, including about half a million physicians. We now spend nearly half a trillion dollars, about 11 ...

No extract is available for articles shorter than 400 words.

To the Editor: The short stature of pygmy people has intrigued observers for many centuries. Herodotus discussed this matter, the Romans knew about pygmies, H.M. Stanley measured them, and in the 19th century, at least two pygmies were taken to Italy, ...

To the Editor: Ratliff and colleagues (Jan. 22 issue) ¹ reported the usefulness of endomyocardial biopsy for the diagnosis of chloroquine cardiomyopathy in patients with lupus erythematosus. They stated that "documentation of cardiac involvement in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This surgical atlas has interesting roots. In their introduction, the editors claim that the choice of procedures compiled here was based on the extensive work of Rob. They acknowledge that this selection is not necessarily perfect, and a stricter ...

Vascular access has become a cornerstone in the management of a variety of illnesses. Acute and chronic renal failure, long-term intravenous hyperalimentation, cancer chemotherapy, and plasmapheresis are several of the clinical situations in which ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.