IN 1983 Warren and Marshall showed an association between the presence of curved or spiral-shaped bacteria on the surface of the gastric mucosa beneath the mucous layer and histologic evidence of antral gastritis.¹ Several reports have subsequently ...

COLCHICINE causes a characteristic myopathy in animals,¹ but although the drug has been used therapeutically for more than 200 years,² myopathy associated with its long-term use in humans has been reported only twice previously.^{3 , 4} The first case, which ...

THE incidence of neurosyphilis has decreased markedly since the introduction of penicillin, but cases are still encountered.¹ In the era before antibiotics, only 6.5 percent of patients with untreated syphilis went on to have symptomatic neurologic ...

SECONDARY hyperparathyroidism often accompanies chronic renal failure.^{1 , 2} In addition to phosphate retention^{3 4 5 6} and skeletal resistance to the calcemic action of parathyroid hormone,^{7 8 9} decreased serum 1,25-dihydroxyvitamin D (1,25-(OH)₂D [1,25-...

MY theme today relates to an ageless question in medicine: Just what is quality care? That question has been with us since the Code of Hammurabi was set down. And right here in Boston at the turn of the century, a surgeon named Codman came to grips with ...

(Second of Two Parts)

Molecular Genetics of 21-Hydroxylase Deficiency

It has been demonstrated that the HLA-linked defect in 21-hydroxylase deficiency involves a structural gene for the corresponding cytochrome P450 (P450c21). A bovine cDNA clone was ...

TREPONEMA pallidum, the etiologic agent of syphilis, may be detected in the cerebrospinal fluid during early infection. The recommended therapeutic agent for primary, secondary, and latent syphilis, benzathine penicillin, does not reach treponemicidal ...

Presentation of Case

A seven-year-old boy was admitted to the hospital because of right otitis media and mastoiditis.

He was well until several days earlier, when his parents noticed drainage from his right ear a few days after he had been swimming. A ...

IT is difficult for those of us practicing modern-day medicine to comprehend how pervasive syphilis was in the pre-antibiotic era. For example, medical textbooks commonly divided the discussion of organ systems into sections on congenital defects, tumors, ...

THE two major hormones that regulate calcium homeostasis are parathyroid hormone and the active form of vitamin D₃ (l,25-(OH)₂D₃).¹ These hormones work in concert to mobilize calcium from bone and act separately to increase the reabsorption of calcium by ...

Since 1983, information has rapidly accumulated on the proposed role of the bacterial strain now called Campylobacter pylori (formerly C. pyloridis) in causing inflammation and damage to cells of the antrum of the stomach. In that year, Warren and ...

To the Editor: The report by Summers et a!. (Nov. 13 issue)* contains methodologic problems that render the results difficult to interpret.

First, the selection of outcome variables is inappropriate. The neuropsychological assessment techniques employed ...

Editor's note: Since publication of the article by Summers et al. in our November 13th issue, we have learned that Dr. Summers had formed a private, for-profit corporation (Solo Research, Inc.) for the purpose of making treatment with THA available to ...

No extract is available for articles shorter than 400 words.

To the Editor: Hemophilus influenzae type b is one of the important causes of serious bacterial infections in children. Since the first cases of H. influenzae type b cellulitis in adults were reported by Drapkin et al. in 1977,¹ there have been six more ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: A high-molecular-weight form of thyrotropin (>200,000 daltons) with reduced potency in adenylate cyclase assays but the ability to bind normally to the thyrotropin receptor was the only radioimmunoassayable thyrotropin in a healthy young ...

No extract is available for articles shorter than 400 words.

Guyton's Textbook of Medical Physiology (7th ed. Philadelphia: W.B. Saunders, 1986) is one of the most widely used medical textbooks in the world. His approach has drawn criticism for oversimplifying complex concepts, sometimes at the expense of absolute ...

Students of the late Dr. H. Houston Merritt found that although he nearly always reached the correct diagnosis before they did, his laconic style kept secret just how he got there. Many textbooks of neurology, lacking sections on history and examination, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This is a highly readable, unified set of chapters, each covering a major topic in this blossoming area of neurology. The book is written for clinicians interested in movement disorders, but it belongs in the library of all clinical neurologists, the ...

No extract is available for articles shorter than 400 words.