WE have previously reported the results of therapy in 25 patients with advanced cancer who were given a single course of lymphokine-activated killer (LAK) cells and interleukin-2.¹ This treatment, referred to as adoptive immunotherapy,^{2 , 3} involved ...

MONONUCLEAR cells exposed to interleukin-2 develop broad cytotoxic reactivity against autologous and allogeneic tumor cells.^{1 , 2} Treatment of tumor-bearing mice with recombinant interleukin-2 (rIL-2) and rIL-2–activated lymphocytes can produce partial ...

WE reported in 1981 that serum concentrations of insulin-like growth factor (IGF) I are decreased in African pygmies. Since levels of growth hormone and IGF II were normal in these subjects, we concluded that a deficiency of IGF I was the cause of their ...

SMALL-CELL carcinoma of the lung is distinguished from other forms of lung cancer by its characteristic histologic appearance and clinical features.¹ It shares many of the features of tumors curable by combination chemotherapy: rapid progression, short ...

POST-TRANSFUSION hepatitis is common among patients with hemophilia who are treated with commercial factor VIII concentrates manufactured from large pools of plasma from paid donors recruited mostly in plasmapheresis centers in the United States.^{1 2 3 4} ...

INHERITED deficiencies of various complement proteins are being recognized with increasing frequency. Careful evaluation of these deficiency states has augmented our understanding of the biologic function of individual components of the complement system, ...

COAGULASE-negative staphylococci have been¹¹ increasilgly recognized as causative agents in sevel l types of infection, including nosocomial bacteremia and infection of indwelling devices, such as prosthetic hea t valv^{1 , 2} 2 a d neurosurgical and ...

Presentation of Case

A 65-year-old woman was admitted to the hospital because of an enlarging goiter and stridor.

The patient was well until 10 months earlier, when she began to experience increasing fatigue, cold intolerance, and alopecia; she also ...

This issue of the Journal includes reports by two different groups of investigators concerning their experience with adoptive immunotherapy for cancer.^{1 , 2} A total of 48 responses (8 complete, 28 partial, and 12 minor) are reported among 146 patients (of ...

How does a human being reach normal adult height and weight? Inheritance sets the broad limits — to wit, the shortest elephant towers over the tallest mouse. Nutrition and other environmental factors, including the psychosocial, interact with a panoply of ...

Some 18 months ago, a Sounding Board article in these pages drew attention to conflicts between peer review and federal antitrust law.¹ In that article, Dr. Leigh C. Dolin, one of several physician defendants facing a judgment for over $2 million in ...

Antonellis — Carl Joseph Antonellis, M.D., of Winchendon, died on December 4 at the age of 71.

Dr. Antonellis graduated from Tufts College Medical School in 1941. He was a member of the American Medical Association, the Southeastern Surgical Congress, and ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The importance of early identification of neonates with maple-syrup-urine disease is well recognized. In this disorder, the branched-chain amino acids are transaminated to their α-keto acids, but further metabolism is deficient because of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In an attempt to monitor the use of smokeless tobacco during the fifth game of the 1986 World Series, I used a stopwatch to time televised images of players and coaches actively chewing and dipping smokeless tobacco on camera. A total of ...

Traditional histories of obstetrics in America focus on the great doctors and the major technical advances in the field. These histories have their place, revealing the leaders and their contributions. The writers of these histories have typically been ...

Maternal–fetal medicine was developed as a specialty of obstetrics in the mid-1970s. It has become the academic arm of obstetrics, especially among practitioners caring for patients at high risk. The past decade has seen a marked expansion in our ...

No extract is available for articles shorter than 400 words.

These two companion books will certainly set the standard by which other textbooks in the field are measured. They will face rigorous competition, however; in just the past eight years we have seen rapid growth in the literature on in vitro fertilization ...

It is sometimes said that there are no new frontiers for humanity in an age when we speak of humans walking on the moon in the past tense, when every corner of the earth has been explored, and when even the oceans and the poles are accessible to tourists ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Biomedical Science

Advances in Cyclic Nucleotide and Protein Phosphorylation Research. Vol. 20. Edited by Paul Greengard and G. Alan Robison. 371 pp. New York, Raven Press, 1986. $72.

Alcohol and Brain Development. Edited by James R. West. 440 pp., ...

CONTROVERSIES IN INTERNAL MEDICINE

The course will be offered in Hilton Head. S.C., May 4–8.

Contact CME Dept., Boston Univ. School of Med., 80 E. Concord St., Boston, MA 02118; or call (617) 638–4605.

MASSACHUSETTS MEDICAL SOCIETY

The 1987 annual meeting ...

No extract is available for articles shorter than 400 words.

Congress, moving with unusual dispatch, has enacted an important new law that offers hospitals and physicians that engage in peer review broader legal protection against the threat of being sued by doctors who are disciplined as a result of the review ...