THE increasing resistance of human and animal isolates of salmonella to multiple antimicrobials^{1 2 3 4} has been attributed to antimicrobial use in both humans and animals. The role of animal-to-human transmission in human salmonellosis and the ...

GAUCHER'S disease, the most common sphingolipidosis, is caused by a deficiency of lysosomal glucocerebrosidase (E.C.3.2.1.45).^{1 , 2} On the basis of clinical signs and symptoms, three major clinical phenotypes have been identified. Type 1 (chronic, non-...

CONSIDERABLE evidence indicates that volume expansion causes the release of humoral natriuretic factors.^{1 2 3} Several studies suggest that one of these factors is a circulating digitalis-like substance that inhibits the sodium–potassium pump in various ...

THROMBOCYTOPENIA develops in approximately 1 percent of patients who receive heparin.^{1 2 3 4} Heparin-dependent platelet antibodies are present in the serum of most such patients during the acute episode, and it is generally believed that the ...

SEVERE combined immunodeficiency disease associated with an inherited deficiency of adenosine deaminase (ADA)¹ is usually fatal unless affected children are kept in protective isolation or unless the immune system is reconstituted by transplanting bone ...

IN the midst of another medical malpractice crisis, medical peer-review programs concerning the quality of physicians' performance are receiving renewed attention as at least partial solutions to the problem. State legislatures are mandating comprehensive ...

OVER the past 10 years our quest for discrete pathogenetic mechanisms for the long-term complications of diabetes has gradually focused on three promising targets for specific therapeutic intervention: nonenzymatic glycosylation of proteins, altered ...

Presentation of Case

A 59-year-old woman was admitted to the hospital because of polyneuropathy and weight loss.

She was well until seven years earlier, when she began to notice gradual weight loss. During the three years before admission chronic anemia ...

Traditionally, Gaucher's disease has been divided into three clinical forms, which have recently been reviewed.^{1 , 2} Type 1 disease is a non-neuronopathic, chronic disorder characterized by hypersplenism and bone involvement. This form is the most common ...

The roles of the renin–angiotensin–aldosterone and antidiuretic (vasopressin) systems in regulating extracellular fluid volume and arterial pressure have been recognized for many years. More recently, atrial natriuretic factor was discovered and shown to ...

Inherited disorders have been perceived by the general medical profession as unfortunate accidents of nature that are essentially untreatable. Recently, the imagination of physicians and of the general public has been captured by the possibility of using ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Hadler et al. (July 24 issue)¹ reported that 15 percent of subjects who were successfully immunized with hepatitis B vaccine lost antibody to hepatitis B surface antigen (anti-HBs) during the five-year period after immunization. In another ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book, by a distinguished pulmonary and cardiovascular investigator and Nobel laureate, is appropriately subtitled. The first third of the book recounts the author's personal and family history, describing his early life in France. As the son of a ...

In recent years historians of many stripes have become interested in the history of disease, particularly epidemic disease. The authors of the two books reviewed here represent two very different approaches. Carmichael uses her medical training to ...

"Biotechnology, a science capable of being commercialized, has been totally dependent on university research. In no other fledgling industry have university scientists played such an all-encompassing role." Perhaps the landmark event was the development ...

The placebo is used in medical practice today as both a therapy and a substitute. As a substitute, it may be an inactive — or as the British call it, a "dummy" — drug used often in controlled medical trials. The placebo as therapy is used primarily for ...

The intensive care nursery has been described as a world of its own, and to this world two professors of sociology from Boston College have come like Margaret Mead to New Guinea. They use the approach of sociologists to describe professional groupings, ...

Most physicians who work with children must confront the elusive concept of "hyperactivity." For the clinician attempting to find a way through the jungle of terminology, disparate theories, and the conflicting results of literally hundreds of studies, ...

Medicine

Viral Hepatitis. (Proceedings in Life Sciences.) Edited by F. Callea, M. Zorzi, and V.J. Desmet. 110 pp., illustrated. New York, Springer-Verlag, 1986. $37.40.

A Year in nutritional Medicine. Second edition, 1986. Edited by Jeffrey Bland. 343 pp. ...

GASTROENTEROLOGY

A course entitled "7th Annual Advances in Gastroenterology" will be offered in Atlantic City, N.J., on June 13.

Contact Registration Supervisor, SLACK Inc., 6900-Grove Rd., Thorofare, NJ 08086–9447; or call (609) 848–1000.

ANGIOPLASTY AND ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The long, painful process of reconciling society's preference for low taxes and limited government with its steadfast support of a broad range of publicly funded services will continue this year, with medical care in the eye of the Reagan administration's ...