THE prognosis for children with acute lymphoblastic leukemia (ALL) in whom relapse in bone marrow occurs during initial therapy or shortly thereafter has been dismal. Most of these patients do not have long-lasting second remissions and eventually die.^{1 2} ...

CREUTZFELDT–JAKOB disease is a fatal, transmissible form of dementia.¹ The infectious agent is referred to as an "unconventional" virus² or prion.³ There is no specific immune response to the infectious particle in the brain,⁴ serum,⁵ or cerebrospinal ...

THE differential diagnosis of erythrocytosis due to an unknown cause, after the exclusion of both polycythemia rubra vera and secondary erythrocytosis attributable to an associated disorder, can be a difficult problem. Estimates of erythropoietin by ...

PANCREATIC polypeptide is the hormonal product of a distinct type of endocrine cell that is a major component of the islets of Langerhans.^{1 , 2} It is composed of 36 amino acids, but its physiologic function has not been clearly defined. The cells that ...

SEVERAL studies have concluded that the consistent use of formal clinical guidelines for the provision of respiratory-therapy services can result in cost reductions.^{1 , 2} These data are important in the light of attempts by third-party reimbursement ...

RECENT advances in the diagnosis and classifcxation of epileptic seizures and epileptic syndromes, together with improvemenss in anticonvulsant therapy, have enabled the great majority of patients with primary generalized epilepsy to be correttly ...

FETAL diagnosis is a young and rapidly changing field of study aimed at detecting fetal disease and improving its management. The current success of fetal diagnosis is the product of new methods for the anatomical and biochemical evaluation of the unborn ...

Presentation of Case

A 74-year-old man was admitted to the hospital because of weakness and incontinence.

There was a 13-year history of bronchial asthma. Several years after its onset he was treated at another hospital for a carcinoma of the urinary ...

The era of effective chemotherapy for acute lymphoblastic leukemia in children began almost four decades ago with an article in the Journal in which Sydney Farber and his coworkers¹ described their results with aminopterin. In the two decades that ...

The unplanned shift from the cost-reimbursement method of paying for all medical services to fixed-dollar allowances has created a need to look critically at what we are doing in our entire health care delivery system. The burgeoning field of respiratory ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In their article in the February 20 issue, Rajfer et al. conclude that hormonal treatment is in most cases ineffective in promoting testicular descent.¹ In addition, they claim that the success rate of over 50 percent achieved by treatment ...

To the Editor: In a letter to the Editor (Sept. 5 issue),¹ Williams et al. suggested that chromosome analysis is emerging as a valuable tool in identifying prognostically important subgroups of patients with acute lymphoblastic leukemia. Their series ...

No extract is available for articles shorter than 400 words.

To the Editor: The article by Steinwachs et al. (Jan. 23 issue)¹ is a large study that uses data from three health maintenance organizations (HMOs) to estimate the future demand for physicians and compares these estimates with projections made by the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The management of thyroid ophthalmopathy is a problem faced by internists, endocrinologists, ophthalmologists, radiation therapists, and otolaryngologists. Despite an extensive literature from many fields of medicine, the precise relation between thyroid ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The purpose of Problems in Aesthetic Surgery is to give the aesthetic surgeon (and most plastic surgeons do aesthetic surgery) a basic understanding of what he or she is or should be doing. It succeeds in stimulating those of us who do this kind of work ...

No extract is available for articles shorter than 400 words.

This book differs from others on the same subject because of its analyses of decision-making processes. Moreover, it combines the best elements of two classic textbooks, Surgery of Head and Neck Tumors (New York: Hoeber-Harper, 1957), with its emphasis on ...

Biomedical Science

Advances in Gene Technology: Molecular biology of the endocrine system. (ICSU Short Reports. Vol. 4.) Edited by David Puett, Fazal Ahmad, Sandra Black, et al. 402 pp., illustrated. New York, Cambridge University Press for the ICSU Press,...

OCCUPATIONAL HEALTH

The fourth annual Occupational Health & Safety Institute will be held in St. Paul, Sept. 8–19.

Contact Programs in Continuing Education — Occupational Health, Midwest Ctr. for Occupational Health & Safety, 640 Jackson St., St. Paul, MN ...

The availability of imaging by high-resolution dynamic ultrasonography to detect fetal abnormalities and delineate their natural history and progression has intensified our approach to the fetus as a patient.^{1 , 2} Although medical procedures that are ...