CONTROLLED studies have shown that plasma-derived hepatitis B vaccines are highly effective in providing protection against hepatitis B virus (HBV) infection.^{1 2 3 4 5 6} Protective antibodies (antibody levels above 9.9 sample ratio units [SRU] by ...

Unstable metabolic control is a common problem in young patients with insulin-dependent, Type I, diabetes mellitus (IDDM), particularly during adolescence. With the onset of puberty, glycemic control usually deteriorates, as reflected by rising ...

In addition to obesity, which is a well-established cause of peripheral resistance to insulin action,¹ the distribution of body fat also influences resistance to insulin and the risk of non-insulin-dependent diabetes mellitus (NIDDM).^{2 3 4 5 6 7}

Compared ...

Although several studies have addressed the prevalence and mechanisms of insulin resistance in Type I diabetes,^{1 2 3 4 5 6} the natural course and clinical importance of insulin resistance are poorly understood. In newly diagnosed patients, insulin action ...

The BK type of human polyomavirus is ubiquitous and infects a large proportion of the population, as indicated by serologic surveys.^{1 , 2} Primary infection occurs in childhood and is sometimes associated with a mild respiratory illness.³ The virus ...

The acute hepatic porphyrias are diseases in which the production of heme is deficient because of inherited abnormalities in specific enzymes of the heme synthetic pathway.¹ The goal of therapy for these diseases is replenishment of cellular heme. This ...

Botulism is a neuroparalytic illness caused by the action of a heat-labile neurotoxin elaborated by Clostridium botulinum. Botulism in adults typically results from ingestion of preformed toxin in contaminated food, whereas in botulism in infants and in ...

Presentation of Case

A 38-year-old woman was admitted to the hospital because of a question of sepsis.

She was in a stable state of health until two days earlier, when she received an unprovoked dog bite on the right lower leg while camping with her ...

A useful message to the Journal's readership is contained in the report by Hadler et al.¹ on the protective value of hepatitis B antibody that persists after immunization. Questions about the efficacy of the vaccine have been among the reasons for many ...

In a classic article in 1965, Shipp et al. reviewed the subject of insulin resistance in diabetes (defined as an insulin requirement of more than 200 U per day) and declared it a rare complication that occurred in only about 0.01 percent of all diabetic ...

Botulism is a severe paralytic disease caused by the most potent of all natural toxins, according to lethality assays in animals. The appellation "botulism" is derived from the Latin botulus, in reference to the improperly prepared blood sausages that ...

Altman – William Solomon Altman, M.D., of Quincy, died on June 2 at the age of 83.

Dr. Altman graduated from Tufts College Medical School in 1927. He was a member of the American Medical Association, the Radiological Society of North America, the American ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Here are several supplementary comments on the excellent report on retinoic acid embryopathy by Lammer et al. (Oct. 3 issue).* Since the time of that compilation of cases (July 1984), 20 additional cases of isotretinoin embryopathy have ...

To the Editor: Tumor lysis syndrome develops rapidly after effective therapy of several malignant conditions and is characterized by the rapid death of neoplastic cells, leading to hyperuricemia, hyperkalemia, hyperphosphatemia, and hypocalcemia.¹ ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: As a medical educator, I share the concern of Siden et al. (Feb. 20 issue)* that inaccurate and improper information is being communicated to medical students by misinformed and perhaps somewhat paranoid physicians. My interests and ...

No extract is available for articles shorter than 400 words.

The need for a good introductory neuroscience textbook has become increasingly apparent. This second edition of Basic Neuroscience by Afifi and Bergman has been expanded. Discussions of relevant aspects of applied anatomy and clinical correlation have ...

The history of medicine is noticeably short on works dealing with the development of therapeutics. Aside from Swazey's ChlorpromaZine in Psychiatry: A Study of Therapeutic Innovation (Cambridge, Mass.: MIT Press, 1974), the somatic therapies for mental ...

This is a book about people and their neurologic disorders. Each of the chapters deals with the story of a patient, one of the many amazing phenomena of neurology, or both. The way in which brain disorders determine inner lives and relationships with ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

It appears to be an unwritten rule of many teachers of branches of medicine generally regarded as particularly difficult that one must publicly maintain that the field is really quite simple. In general, this can be seen as a harmless affectation, similar ...

Aphasia research is concerned with a frustratingly complex area of human behavior and human dysfunction. It is long overdue for a new direction. Here, the author's preface promises that he may be the one to provide such a direction. He posits that "...

Biomedical Science

Adenovirus DNA: The viral genome and its expression. (Developments in Molecular Virology 8.) Edited by Walter Doerfler. 458 pp., illustrated. Boston, Martinus Nijhoff, 1986. $72.50.

Advances in Human Genetics. Vol. 15. Edited by Harry ...

RADIOLOGY

The 15th annual Wendell G. Scott Lecture will be delivered at the Mallinckrodt Institute of Radiology at the Washington University Medical Center in St. Louis, on September 8. The topic will be "Regulation and Education: Is There a Proper ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.