Current intensive regimens of chemotherapy for the treatment of acute nonlymphocytic leukemia result in prolonged first remissions in a substantial proportion of patients, who may ultimately be cured of their leukemia.^{1 2 3} However, patients who have one ...

Poor control of blood glucose concentrations in insulin-dependent diabetic patients can be attributed to many variables, including dietary indiscretion,¹ inappropriate schedules of insulin injection,² an absence of endogenous insulin,³ and an ...

DURING cardiopulmonary arrest and cardiopulmonary resuscitation, a critical reduction in tissue perfusion and the consequent failure to maintain oxygen delivery cause anaerobic metabolism and lactic acidosis.^{1 , 2} Measurements of arterial blood gases may ...

Hyperphosphatemia has a key role in the development of secondary hyperparathyroidism and renal osteodystrophy in patients with uremia. Although controversy exists¹ regarding the exact mechanism by which retention of phosphate produces secondary ...

The chlamydia genus has two species: trachomatis and psittaci. Chlamydia psittaci infections (psittacosis), which are usually associated with pneumonia, have been recognized for many years. A continuing source of human infection is pet birds. Outbreaks of ...

In one of those delightful essays in The Doctor's Saddle-Bag,¹ a former editor of the New England Journal of Medicine, Dr. Joseph Garland, recalled the advice given by the "autocrat of the breakfast table" to the young practitioner: "Do not dabble in the ...

Trigeminal neuralgia, or tic douloureux, denotes a specific type of facial pain that has these features: (1) occurrence in abrupt, intense paroxysms, (2) usually provocation by a minimal local stimulus to the affected side of the face, (3) unilaterality, ...

Presentation of Case

An eight-year-old girl was admitted to the hospital because of multiple osteolytic lesions.

She was well until approximately six months earlier, when varicella occurred; after several weeks at home she returned to school. During the ...

In the past five years, the chances of successfully using autologous marrow transplants in cancers that may involve the marrow itself have been dramatically improved with the development of strategies for eradicating contaminating malignant cells from the ...

The determination of "blood gases" in the current clinical vernacular means the measurement of pH, partial pressure of carbon dioxide (PCO₂), and partial pressure of oxygen (PO₂) in fresh samples of whole blood drawn without exposure to air and usually ...

The genus chlamydia consists of two species, psittaci and trachomatis. C. psittaci attracted attention during a pandemic in 1929–1930, when it was shown to cause psittacosis ("parrot fever," from the Greek word psittakos, "parrot").¹ Exotic birds are not ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the August 1, 1985, issue of the Journal, Chilcote et al. reported an association between childhood acute lymphoblastic leukemia (ALL) with lymphomatous features and partial deletion of the short arm of chromosome 9 — del(9)(p21–p22).¹ ...

To the Editor: We wish to report a case in which an 81-year-old man had a disseminated neuroblastoma that apparently arose from a posterior mediastinal tumor that had been present for at least 52 years. This case may offer insight into the pathogenesis ...

To the Editor: Enalapril (MK-421; ethyl ester of N-[(S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl-L-proline) is a long-acting inhibitor of angiotensin-converting enzyme that is used in the treatment of hypertension.¹ The drug appears to be safe in the ...

To the Editor: Godfrey's article (Dec. 26 issue)¹ on simple regression overlooked one point. Too frequently researchers assume that the statistical significance of a correlation coefficient is synonymous with biologic importance. Too often the estimated ...

To the Editor: An article in the January 9 issue¹ contained suggestions about the future economic performance of not-for-profit and investor-owned chain hospitals based on a comparative study using 1978 and 1980 data. The conclusions of the authors are ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In a unique departure from talking about talking, Eric Cassell recorded hundreds of conversations between physicians and patients and organized many of these vignettes around a linguistic analysis (Volume 1) and clinical technique (Volume 2). From his ...

No extract is available for articles shorter than 400 words.

Generations of medical students, residents, and research fellows in gastroenterology–hepatology have been raised on the first six editions of Dame Sherlock's remarkable magnum opus. I am pleased to report that the torch has not been passed. This seventh ...

This book was written "for physicians and other professionals who provide care for patients with diabetes mellitus." This is a tall order for a single book, but it comes close to that ambitious goal.

The initial chapter on diagnosis is brief but ample. It ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Canada's health care system, the nation's most popular publicly financed service, has for years demonstrated a capacity to deliver universal, high-quality medical care for considerably less than the cost of care in several other Western industrialized ...