SYNTHETIC derivatives of vitamin A (retinoids) are currently being tested in diseases treated by a variety of specialists, including dermatologists (cystic acne, psoriasis, and disorders of keratinization), oncologists (treatment and prevention of cancer ...

PHYSICIANS need to understand the importance of abnormalities of the electrocardiogram in "normal" persons, because electrocardiographic examinations are often carried out for life-insuranceance or employment purposes, for preoperative evaluation, or as ...

THE recent development of molecular biologic techniques has made possible studies of hepatitis B virus (HBV) DNA in tissue-culture cell lines and in clinical materials, including needle-core specimens.^{1 2 3 4} With the use of these techniques, the state of ...

IN 1984, the Department of Transfusion Medicine of the National Institutes of Health began to use automated platelet-collection systems instead of manual methods. Six of the first 600 donors who underwent automated platelet-pheresis procedures had ...

THE tragic loss of the space shuttle Challenger and its crew intensifies the need to identify meaningful long-term goals for the space program. The current hiatus in activities in space should be used to reexamine the fundamental question that has ...

LYSOSOMAL disorders in humans due to deficiencies of lysosomal enzymes or effector proteins (activator or protector proteins) have been described for most steps in the catabolism of glycoproteins, glycolipids, and glycosaminoglycans (mucopolysaccharides).^...

ORNITHINE transcarbamylase is a hepatic urea-cycle enzyme that is required for the detoxification of ammonia and the biosynthesis of urea.¹ Human ornithine transcarbamylase deficiency, an X-linked disorder,^{2 , 3} results in severe and often fatal neonatal ...

Presentation of Case

An 80-year-old woman was admitted to the hospital because of confusion after a fall.

She felt well until six days earlier, when she fell and injured her right hip and became inactive because of pain. Two days before admission her ...

Providing health care for the poor is one of the important public-policy problems confronting our society. It is well recognized that the size of the budget deficit imposes a formidable constraint on the development of a federal solution to this problem. ...

Any discussion of ethical issues from a nursing perspective must take into consideration the particular context of nursing. Ordinarily, nurses do not function as self-employed practitioners with a high degree of autonomy and freedom. Rather, most are ...

Dietary management of diabetes mellitus is stressed in current textbooks and articles on treatment of the disease. Diet in diabetes has had a distinguished, controversial, 3500-year history,¹ and through the years, tradition, as opposed to scientific ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: β-Mannosidosis is a recently described inherited disorder of glycoprotein catabolism in goats.¹ We would like to report a deficiency of acid β-mannosidase activity in plasma, leukocytes, and cultured skin fibroblasts from an Indian Hindu ...

To the Editor: Creutzfeldt–Jakob disease, kuru, and the Gerstmann–Sträussler syndrome are transmissible encephalopathies of humans caused by unusual slow infectious pathogens^{1 , 2} that have been labeled "prions" by one of us (S.B.P.).^{3 , 4} Scrapie of ...

To the Editor: The measurement of pulmonary artery occlusion pressure, or "wedge" pressure, is performed frequently and provides important physiologic information.¹ In a recent clinicopathological conference, considerable discussion focused on the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In 1981, Katie Laurel Wells was born with a cleft lip, an optic-nerve defect, and limb abnormalities, including absence of the left arm. Her mother had used vaginal spermicides during the first four weeks after conception. In 1982, her parents brought ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This fifth edition reflects the progress that urology has made over the past decade. It maintains the basic organization of the fourth edition, but the content is representative of the transformation of urology from a field whose body of knowledge was ...

Wound Care

Edited by Stephen Westaby. 285 pp., illustrated. St. Louis, C.V. Mosby, 1986. $27.95 (hardcover); $19.95 (paperback). (Reprinted with corrections [first published, London, William Heinemann, 1985].)

These two new books, which deal with related ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Biomedical Science

The Adrenal Gland and Hypertension. (Serono Symposia Publications from Raven Press. Vol. 27.) Edited by F. Mantero, E.G. Biglieri, J.W. Funder, and B.A. Scoggins. 465 pp., illustrated. New York, Raven Press, 1985. $63.50.

Advances in ...

CALL FOR PAPERS

Abstracts and papers are now being accepted for the 15th annual meeting of the North American Primary Care Research Group, to be held in Minneapolis, May 17–20. The abstract deadline is Nov. 28.

Contact CME Dept., Univ. of Minnesota, Box ...