A REVIEW of the treatment of childhood acute lymphoblastic leukemia in the past decade suggests that prolonged disease-free survival in most studies has ranged from 50 to 70 percent.¹

In a series of trials conducted between November 1973 and December ...

The malignant carcinoid syndrome has excited clinical interest and posed a therapeutic challenge since it was first described more than 30 years ago. Although the disorder is usually associated with carcinoid tumors of the small bowel that are metastatic ...

It has been suggested that the strong association between maternal connective-tissue disease and congenital complete heart block¹ is a consequence of transplacental passage of antibodies to soluble tissue ribonucleoprotein antigens.^{2 , 3} Maternal ...

Routine pretreatment staging is of considerable importance in defining the natural history, clinical prognosis, and post-treatment evaluation of malignant lymphomas. Numerous staging procedures are required to assess the extent of visceral and nodal ...

The mammalian erythrocyte is structurally designed to withstand considerable deformation by fluid shear forces in the peripheral circulation without fragmentation or permanent distortion of its biconcave disk shape.¹ The remarkable strength and ...

Recent observers have suggested that suicides.. by teenagers occur in "clusters" and that these clusters are caused by imitation.^{1 2 3 4 5 6 7} Most of the published evidence on this topic is anecdotal, however, and alternative explanations for the ...

Suicide is a complex human act that is probably determined by biologic predisposition, experience, and the environment. One environmental factor that has attracted considerable attention has been imitation, which is presumed to have a role in so-called ...

Presentation of Case

A 29-year-old woman was admitted to the hospital because of weakness of proximal muscles.

She was born of a normal gestation and delivery. She rolled over and sat up at normal times but was slightly slow to walk. Throughout her early ...

The carcinoid syndrome is an endocrine manifestation of neoplastic enterochromaffin cells. The humoral consequences of enterochromaffin carcinoid tumors include cutaneous flushing, diarrhea, valvular lesions of the right side of the heart, ...

The article by Carrasquillo and colleagues in this issue¹ is one step along the path taking the production of monoclonal antibodies from a laboratory tour de force to a usable diagnostic or therapeutic clinical tool. Despite the small number of patients ...

Among American adolescents between 15 and 19 years of age, suicide is the second most important cause of death, resulting in almost 1700 lives lost each year. In 1983, the latest year for which national data are available, the mortality rate from suicide ...

No extract is available for articles shorter than 400 words.

To the Editor: With reference to the thorough review of ascorbic acid by Dr. Levine (April 3 issue),¹ we wish to alert readers to one clinically relevant aspect that needs to be appreciated more fully—namely, the interaction of ascorbic acid with iron.

...

To the Editor: Great interest has been aroused by the discovery of the putative natriuretic hormone atrial natriuretic peptide.¹ However, the circulating concentrations of many hormones are subject to diurnal variation. Care must be taken to make ...

To the Editor: We report the correlation of silicon with calcium and aluminum in hippocampal neurons bearing neurofibrillary tangles in Guamanian patients with amyotrophic lateral sclerosis (ALS) and parkinsonism with dementia, with use of a computer-...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In the three decades since the California Court of Appeals used the phrase "informed consent" in the Salgo decision, an enormous amount of literature has been produced on the subject. Faden and Beauchamp's book ranks with the best. Their goal is precise: ...

Physicians who seek to learn what economics can offer in understanding and improving the health care system can find out all they need to know, and some extra, by reading this book. This is the first "textbook" in health economics, and it is well ...

No extract is available for articles shorter than 400 words.