IN 17 to 30 percent of patients with the Zollinger–Ellison syndrome, the gastrinoma contains both gastrin and ACTH-like immunoreactivity,^{1 2 3} but an association between the Zollinger–Ellison syndrome and Cushing's syndrome has been described only rarely.^...

THE hypothesis that interferon-γ is a physiologic macrophage-activating factor in humans¹ can be tested by determining whether small doses of the pure, recombinant product can improve features of disease associated with inadequate macrophage activation ...

THE relationship between neoplasia and cell differentiation has long been a subject of intense study and debate. The presence of defined developmental hierarchies of myeloid cells in the leukemias renders them excellent diseases for studying this ...

THE possible risks associated with pregnancy in patients with Graves' disease, such as spontaneous abortion, premature labor, and fetal death, can be decreased by the use of antithyroid drugs of the thionamide group (such as propylthiouracil). Thionamides ...

END-STAGE corneal disease is the leading cause of blindness in the world,¹ and it is currently cured only by transplantation. Although corneal transplantation in most cases is a routine and highly successful procedure, immune-mediated allograft rejection ...

FLECAINIDE acetate (Tambocor, Riker Laboratories) has recently become available in this country for the management of ventricular arrhythmias. The synthesis of flecainide in 1972 was the culmination of a systematic search for fluorinated local anesthetic ...

MANY new antiarrhythmic agents have recently become available in the United States. One of these, an oral form of the lidocaine analogue tocainide (Tonocard, Merck Sharpe and Dohme), was first marketed in November 1984 for use in the suppression of ...

Presentation of Case

A 62-year-old man was admitted to the hospital because of progressive polyneuropathy.

The patient was well until two or three years earlier, when he began to experience burning sensations in the soles of his feet, with numbness of the ...

Accumulating evidence for a unicellular (clonal) origin of leukemia, based on the studies of Fialkow and coworkers employing isozymes of the X-linked gene, glucose-6-phosphate dehydrogenase (G6PD), as clonal markers,¹ combined with evidence from rigorous ...

Disease of the cornea is the most common cause of blindness in the world.¹ The cornea is the normally transparent anterior structure of the eye that functions similarly to the lens of a camera and has the appearance of a watch crystal. The normal cornea ...

Physicians are under increasing pressure from hospitals and managed care plans to practice more efficiently. The focus is no longer on a minority of outliers but instead on the practice patterns of most physicians, since it is recognized that large ...

No extract is available for articles shorter than 400 words.

To the Editor: The article by Platia et al. (Jan. 23 issue)¹ on the management of malignant ventricular arrhythmias by combined endocardial resection and implantation of the automatic internal cardioverter-defibrillator is timely and provocative. We ...

To the Editor: Several approaches, with varying success rates, have been proposed for the treatment of persistent hiccups.¹ Although treatment with amitriptyline has been proposed,² documentation of its efficacy is scarce.

A 17-year-old boy was referred ...

To the Editor: The clinical syndrome associated with ciguatera fish poisoning has been reviewed previously. The dinoflagellate Gambier-discus toxicus is the implicated source of toxicity.¹ The symptoms associated with ingestion of the toxin are confined ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Case 5–1986 (slow-growing carcinoid tumor), in the February 6 issue,¹ when compared with previous cases of carcinoid tumors reported in the Journal,^{2 3 4} suggests that the "cascade effect"⁵ has occurred.

When the patient presented, ...

No extract is available for articles shorter than 400 words.

To the Editor: We would like to support and expand the conclusions drawn by Dr. Shea and Fullilove in the October 10 issue.¹ We share their understanding that the diminished commitment of medical schools to affirmative action for black and other minority ...

No extract is available for articles shorter than 400 words.

Saranac, "American culture seen through the prism of tuberculosis," is a remarkable experience. A haunting railroad station on the jacket leads the reader into an extraordinary land where cure had a special meaning, a country from which no traveler, if ...

Few historians would dispute that the "modern" era of American medicine began in the early years of this century with the confluence of a number of unprecedented forces: the promise of the new biomedical science, the reorganization of the hospital as a ...

William Hunter would have fared better in history had it not been for his more famous younger brother John, who still overshadows him. Yet William merits recognition for his own feats. This book, which is based on a symposium, is an attempt to illuminate ...

The author of this two-titled work has long been known to have a firm place in the history of research in surgical shock and cardiovascular surgery because of his association with Alfred Blalock. Although the book's second title indicates this, it has not ...

In this book, the author accomplishes what historians have attempted to do with only partial success: she delineates the intricate role of woman physicians in America from Victorian times to the present without demeaning their struggles toward two ideals ...

Relationships between patients and doctors have changed dramatically since World War II. High-technology medicine, the complexity of diagnosis, awesome therapy, and the mandated governmental and third-party insurance restrictions on hospital stays all ...

Neurology and Psychiatry

Applications of Systemic Family Therapy: The Milan Approach. (Complementary Frameworks of Theory and Practice. Vol. 3.) Edited by David Campbell and Rosalind Draper. 305 pp. Orlando, Fia., Grune and Stratton for the Institute of ...

MEDICAL SYMPOSIUM

The fifth Bar Harbor Medical Symposium will be held at the Atlantic Oakes By-The-Sea, Bar Harbor, Me., August 11–13. The fee is $250.

Contact Joanne Adams, Medical Care Development, 11 Parkwood Dr., Augusta, ME 04330; or call (207) 622–...

No extract is available for articles shorter than 400 words.

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the June 1982 issue of the Annals of ...