Controversy has arisen about whether long-term therapy with digoxin increases mortality in patients who have had a myocardial infarction.^{1 , 2} Reports from three large observational studies of patients after myocardial infarction (Moss et al.³ in 1981, ...

Cigarette smoking is a major risk factor for coronary heart disease, and epidemiologic studies have established a gradient of risk: the highest for continuing smokers, intermediate for reformed smokers, and the lowest for nonsmokers.^{1 , 2} Studies of ...

Perinatally acquired Chlamydia trachomatis infection is an important threat to the well-being of newborn infants.^{1 , 2} Approximately two out of three infants who are exposed to C. trachomatis acquire the infection. Although asymptomatic infections do ...

THE well-documented serologic response of over 2000 persons vaccinated intradermally in the United States with three doses of human diploid-cell rabies vaccine has led to the widespread use of this regimen for preexposure immunization.^{1 , 2}

In August ...

Nearly 50 years have passed since Glover reported a 10-fold difference in tonsillectomy rates among various geographic areas in England.¹ Since then, other researchers have documented similar variations in hospital admissions, lengths of stay, and ...

The treatment of congestive heart failure has traditionally centered on the judicious use of rest, diuretics, cardiac glycosides, and restriction of dietary sodium.¹ More recently, manipulation of cardiac preload and afterload with vasodilating drugs has ...

There has been a substantial amount of commentary about the Twenty-fifth Amendment to the Constitution since President Reagan's colon operation for removal of a cancerous growth, a villous adenoma. Much of the analysis has been confusing and overly ...

Presentation of Case

An 18-year-old woman was admitted to the hospital because of nausea, vomiting, arthralgia, and hypotension.

She was well until eight weeks earlier, when a sore throat developed at about the time of her menses, accompanied by mild ...

The amount of medical care people receive varies substantially, depending on the local hospital market area^{1 2 3 4 5} and the region⁶ or the country where they live. In this issue, Chassin and his colleagues⁶ show large variations in the rates of most ...

The introduction of a new medical treatment into clinical practice often necessitates spending a large amount of money on both basic and clinical research. Such research costs are usually borne by granting agencies or industry. It appears that efforts are ...

No extract is available for articles shorter than 400 words.

To the Editor: The mechanisms behind cluster headache are poorly understood. The strict unilaterality of symptoms and facial distribution of pain, together with relief by interference with trigeminal-nerve and facial-nerve pathways, suggest involvement ...

To the Editor: Aspirin inhibits platelet function by irreversible acetylation of platelet cyclooxygenase.^{1 , 2} In healthy subjects,^{3 , 4} patients who have had a myocardial infarction,⁵ or patients with atherosclerosis⁶ or cerebrovascular disease,⁷ ...

No extract is available for articles shorter than 400 words.

To the Editor: Clinical practice in cases of serious overdose includes the administration of activated charcoal to decrease drug absorption from the gastrointestinal tract. There is also evidence that activated charcoal can decrease the serum half-life ...

To the Editor: Liver-biopsy findings in amiodarone treatment have revealed the presence of Mallory bodies and micronodular cirrhosis and a resemblance to alcoholic liver disease.^{1 2 3} However, a review of the literature revealed only one death from ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: A radiographic survey of the cervical spines of 41 institutionalized patients with Down's syndrome was recently conducted for the purpose of detecting asymptomatic atlantoaxial subluxation. In addition to uncovering 6 such cases, we ...

To the Editor: The hepatitis D virus, or delta agent, is a defective RNA virus that can replicate only in the presence of hepatitis B virus. Superinfection with delta agent of a carrier of hepatitis B surface antigen or a coinfection with delta agent and ...

To the Editor: The hypothalamic-pituitary axis has long been thought to have a major role in the neuroendocrine pathway of immunomodulation: in rats hypothalamic damage leads to abrogation of natural-killer-cell activity,¹ and in mice fetal ...

To the Editor: The finding by Kuribayashi and co-workers (May 30 issue),¹ coupled with the observation of decreased plasma epinephrine levels after intravenous injection of an atrial natriuretic peptide (human a-atrial natriuretic peptide [α-hANP]) in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Another cancer textbook? In the 12 years since Holland and Frei's landmark Cancer Medicine (Philadelphia: Lea and Febiger, 1973) first appeared and the American Board of Internal Medicine introduced examinations in medical oncology, a number of new ...

One could perhaps make a case for another textbook or another series on tumor immunology, particularly when immunology is experiencing a spectacular renaissance. Here are two such offerings. Both books are intended, in large measure, for clinical ...

No extract is available for articles shorter than 400 words.

Reducing federal support for medical education, the central feature of government policy in this sphere over the past decade, is certain to continue this year as Congress moves to implement the new Balanced Budget and Emergency Deficit Control Act of ...