FOR 20 years, children with sickle cell anemia have been known to have an increased susceptibility to severe bacterial infections, particularly those due to Streptococcus pneumoniae. Meningitis, pneumonia, and septicemia caused by this organism have been ...

ALTHOUGH the prognosis for children with osteosarcoma has improved dramatically over the past 15 years, the contribution of adjuvant chemotherapy to this improvement in prognosis has been less certain.^{1 , 2}

Before the 1970s, the prognosis for children ...

THE Prader–Willi syndrome is a congenital disorder that includes infantile hypotonicity; hyperphagia, with obesity developing after the neonatal period; hypogonadism; mental retardation; short stature; and small hands and feet.^{1 2 3 4 5} Specific clinical ...

MAMMALIAN cells have a great demand for cholesterol for the biosynthesis of membranes, bile acids, and steroid hormones. This requirement is met through two interacting pathways. The first is the uptake of external cholesterol, which is facilitated by the ...

MOST postmenopausal women who undertake estrogen-replacement therapy use oral medications. Oral estrogens have exaggerated effects on hepatic processes, as compared with the nonhepatic actions characteristic of estrogens.^{1 2 3} The hepatic effects of oral ...

BECAUSE of cutbacks in federal support for research and other financial pressures, universities are actively seeking ways to benefit from the commercial application of the advances in biotechnology and other fields that are being made on their campuses. ...

Presentation of Case

A 65-year-old woman was admitted to the hospital because of a cough and bilateral pulmonary infiltrates.

She was well until six years earlier, when she began to have scalp pain and tenderness that radiated to the jaw and gums. A ...

Oculocutaneous albinism is an autosomal recessive disorder that is distinguished by uniform hypopigmentation of the skin, hair, and eyes. Involvement limited to the eyes (ocular albinism) has also been described. Because a lack of melanin pigment results ...

Modern pharmaceutics is perhaps four decades old. During this time, the empirical approach to drug delivery has begun to yield to a more theoretical approach, which has brought the principles of physical chemistry to bear on the design of drug-delivery ...

No extract is available for articles shorter than 400 words.

To the Editor: The article by Hallstrom et al. (Jan. 30 issue)¹ entitled "Smoking as a Risk Factor for Recurrence of Sudden Cardiac Arrest" addresses an important issue. However, contrary to the title's implication, the only outcome of sudden cardiac ...

No extract is available for articles shorter than 400 words.

To the Editor: Physicians usually view homeopathic medications as being quaint survivors of the past century and consider that the safety of these preparations is assured by the dilution of their ingredients. Proponents of homeopathy claim that these ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We report an association between fathers' alcohol use in the month before conception and the weight of their infants at birth. This serendipitous finding arose from a study of the familial aggregation of birth weights in humans and how it ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The findings of Sayres et al.* confirm that as women become an increasingly greater segment of the population of residents, the decision to become pregnant has implications extending beyond the individual to the residency program and its ...

These two books are dedicated to the illumination of 21 well-chosen procedures that have evolved because of new concepts, materials, or techniques. They are directed to the experienced practicing surgeon or senior resident. The editors, one each from ...

Resectional surgery for carcinoma of the esophagus in the United States is generally considered to have begun with the report of Adams and Phemister, which was published in 1938, a year after author Raymond W. Postlethwait graduated from Duke University ...

In many respects, this book is a hybrid. Its large format and more than 300 beautiful illustrations suggest a surgical atlas, but the chapter headings represent an effort to provide a comprehensive review of breast disease. Individual chapters come from ...

This book, written by a Welsh physician, addresses the increasingly frequent problem of assessing the operative risks of the elderly, a problem familiar to both surgeons and anesthesiologists.

The opening chapter presents the frequency and nature of ...

Total joint replacement must be included in any list of the major medical achievements of the 20th century. Most will agree that the studies of Charnley in the 1950s on total hip arthroplasty constituted the foundation of this new technology. Unlike total ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Medicine

Heart Disease and Rehabilitation. Second edition. Edited by Michael L. Pollock and Donald H. Schmidt. 752 pp., illustrated. New York, John Wiley, 1986. $47.50.

Hormones and Lung Maturation. (Monographs on Endocrinology. Vol. 28.) By Philip L. ...

HARVARD MEDICAL SCHOOL

A course entitled "Emergency Care: An Extended Workshop" will be held at Massachusetts General Hospital in Boston, September 22-October 3. The fee is $950.

Contact Barbara Wagner, Medical Education Unit, Massachusetts General ...

No extract is available for articles shorter than 400 words.