CHRONIC myelogenous leukemia in patients with the Philadelphia (Ph) chromosome has a typical progressive clinical course that starts with a benign phase and ends in a blastic phase. The benign phase of the disease is easily controlled by single-agent ...

UNTIL barely a decade ago, the mortality at operation among patients with the Marfan syndrome who had surgical repair of an aneurysm of the ascending aorta approached 50 percent. The operation that was used routinely in the early 1970s consisted of ...

SMALL¹ proposed that the formation and progression of cholesterol gallstone disease could be divided into five stages — metabolic, chemical, physical, growth, and symptomatic. To interrupt or reverse the natural progression of gallstone disease, the ...

NORMOGLYCEMIA is the principal therapeutic goal for patients with Type I diabetes.¹ To this end, insulin therapy must be regulated to meet the metabolic requirements associated with changes of diet, physical activity, and physical stress from such causes ...

THE fact that many persons with epilepsy have become famous for their achievements¹ indicates that seizures do not inevitably produce lasting harm to the brain. On the other hand, the reports of intellectual deficits in some populations of epileptic ...

NUMEROUS investigations have examined the importance of the method of payment for health care by comparing patterns of care in health maintenance organizations (HMOs) or other prepaid settings with that in fee-for-service practices. Most of the previous ...

IN this brief review, only an overview of our rapidly expanding knowledge of the organization and function of the calcium messenger system will be possible. This messenger system has a central role in mediating the contraction of all forms of muscle, the ...

Presentation of Case

A 68-year-old right-handed woman was admitted to the hospital because of a progressive speech disorder.

She was well until eight months earlier, when she gradually began to experience difficulty in expressing herself. She groped for ...

Next week, in Washington, D.C., the city where its earliest meetings were held, the Association of American Physicians (AAP) will celebrate its centennial anniversary. It is an occasion of considerable significance for the history of medicine because it ...

I have been dean for student affairs at Harvard Medical School for eight years. It is my responsibility and privilege to listen to medical students and to support their personal and professional development. What they have been telling me this year ...

To the Editor: In 1984, an anonymous report from England described a health care worker in whom antibody to human T-cell lymphotropic virus Type III/lymphadenopathy-associated virus (HTLV-III/LAV) developed after a needlestick injury.¹ Other ...

To the Editor: Concern about the transmission of human T-cell lymphotropic virus Type III (HTLV-III) has resulted in major changes in blood-banking procedures, including the introduction of HTLV-III antibody testing of donated blood in the spring of 1985^...

No extract is available for articles shorter than 400 words.

To the Editor: The use of doxorubicin and vincristine, administered by continuous infusion over four days, in conjunction with dexamethasone to treat multiple myeloma was reported in the Journal in 1984.¹ We used this regimen twice in a man with rapidly ...

To the Editor: The report by Nishimura et al. (November 21 issue)¹ that patients with mitral-valve prolapse whose echocardiographically determined left ventricular diastolic dimension was 60 mm or more were substantially more likely than patients with ...

To the Editor: Prompted by a recent study of congenital heart disease reported in the August 8 issue of the Journal,¹ I analyzed data from a case–control study conducted in Connecticut several years ago.² The cases were 330 heart malformations (...

To the Editor: Clonidine has recently joined scopolamine and nitroglycerin in the growing list of transdermal drug systems. Weekly application of the clonidine system offers an attractive alternative method of drug administration for patients in whom ...

No extract is available for articles shorter than 400 words.

This welcome book provides a comprehensive review of physical growth from the fetus to the adolescent. In his preface, the author rightly emphasizes the importance of knowing the normal, the normal variations, and the reasons for those variations. He ...

No extract is available for articles shorter than 400 words.

Here is a textbook on neurologic problems in children, written as a handbook for physicians in training as well as for experienced pediatricians, neurologists, and family practitioners. The book is admirably suited for such a wide audience. The writing is ...

No extract is available for articles shorter than 400 words.

One of the talents of great teachers, incorporated into their lectures, is the ability to combine basic pathophysiologic mechanisms with clinical disease in a cohesive, logical teaching unit. That many of us strive to perfect that ability and to make ...

To be fair to this solid and practical introduction to pediatric dermatology, which is dedicated "to the many practitioners who provide primary health care for children," I must address several of my biases. Pediatricians have compelling reasons not only ...

This is an anthology of 13 clinical and theoretical papers by psychoanalysts interested in the process of parenting. Their goal, according to the editors, "is to alert the professional world engaged in helping children that [parents] need to be helped... ...

Despite the many advances of our society, we have yet to overcome our major "low-technology" pediatric health problems. Every year in the United States, more than 1 million cases of suspected child abuse and neglect are reported to authorities. On the ...

Losing a child must be among the most devastating of human experiences, yet few investigators have forayed into this domain of the literature on bereavement. Knapp, a professor of sociology at Clemson University, offers this book in an attempt to fill the ...

ALCOHOL AND DRUG ABUSE

A course entitled "The Pharmacology of Chemical Dependence" will be offered in Boston on May 22, and in Chicago on May 29.

Contact the Health and Education Council, 7201 Rossville Blvd., Baltimore, MD 21237; or call (301) 686–3610.

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The acquired immunodeficiency syndrome (AIDS) is caused by a human retrovirus known as human T-cell lymphotropic virus Type III (HTLV-III), also called lymphadenopathy-associated virus (LAV) and AIDS-associated retrovirus.^{1 2 3 4 5 6 7} Serologic tests can ...