THE acquired clonal chromosome aberrations that characterize various malignant hematologic diseases are often associated with a particular cell morphology or immunologic phenotype.¹ Among patients with chronic lymphocytic leukemia, trisomy 12 is found ...

GENERALIZED iron loading due to multiple transfusions is common in β-thalassemia major and steroid-unresponsive Diamond–Blackfan anemia. Since 1962, when administration of intramuscular deferoxamine was shown to increase urinary iron excretion ...

UNDIFFERENTIATED lymphomas similar or identical to Burkitt's lymphoma have been reported with increasing frequency in patients with the acquired immunodeficiency syndrome (AIDS).^{1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17} Like the African Burkitt's tumors, ...

IN familial hypercholesterolemia, a disease with an autosomal dominant pattern of inheritance, a genetic defect in the receptor for low-density lipoprotein (LDL) results in primary hypercholesterolemia and premature atherosclerosis.¹ The more common ...

REGIONAL myocardial contractile dysfunction at rest has been observed to improve after restoration of adequate blood flow.^{1 , 2} It has been shown experimentally that severe reductions in coronary flow may result in loss of regional contractility without ...

THE routine treatment of an individual patient can be likened to an experiment. For example, Feinstein has described the interaction as one in which the patient arrives in an initial state, accepts a treatment proposed by the clinician, and winds up in a ...

ASCORBIC acid, originally called vitamin C, is required for human health.¹ In human beings deprived of ascorbic acid, the deficiency disease scurvy develops and can be life threatening. Although a disease remarkably similar to scurvy was described by the ...

Presentation of Case

A 66-year-old man was admitted to the hospital because of abdominal pain and collapse.

He was well until six years earlier, when hypertension developed. Two years later diabetes mellitus was found, and insulin was begun. A stool ...

Before dialysis therapy was routinely available in the United States, both related and unrelated living donors were accepted for renal transplantation. By 1965, data from the Registry in Human Kidney Transplantation indicated that the success of kidney ...

Home care is currently one of the most rapidly growing fields in health care, yet it is a subject that the majority of physicians know little about. The purposes of this discussion are, first, to explore the reasons for the general isolation of the ...

To the Editor: The article by Hurwitz et al. in the October 3 issue^* poses an anomaly. A pilot study whose purpose was "to examine methods for a larger study" was presented as a substantive study that showed an association between salicylates and Reye's ...

To the Editor: The acquired immunodeficiency syndrome (AIDS) occurs with increased frequency in homosexual men, intravenous drug abusers, patients with hemophilia, recipients of blood transfusions, and close heterosexual contacts of members of these high-...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In 1984, we conducted a study of 114 people who were considered to be at high risk of exposure to polychlorinated biphenyls (PCBs) because of characteristic activity patterns in contaminated areas around three waste dump sites in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

First published in January 1982, this encyclopedic work has, in less than four years, become the standard reference for clinical oncologists of all specialties. According to the editors, the second edition was occasioned by the rapid progress in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

INTERNAL MEDICINE

The Lahey Clinic Foundation will offer a course entitled "Topics in Internal Medicine" at Dunfey's Parker House in Boston, May 1–3.

Contact the Department of Medical Education, Lahey Clinic Medical Ctr., 41 Mall Rd., Burlington, MA 01805;...

Because they can be transmitted to others, infectious diseases of all kinds have for many years been the subject of statutes, regulations, and court decisions imposing special constraints on both the patient's freedom and the physician's practice. The ...