DESPITE improvements in tissue matching and the introduction of newer immunosuppressive agents, acute rejection of the allograft remains a major impediment to the success of clinical renal transplantation. Conventional therapies include the use of high-...

THE clinical syndrome of unstable angina causes great concern to clinicians because of the perceived high risk of progression to myocardial infarction or cardiac death.^{1 2 3 4 5 6} Given the heterogeneous coronary pathoanatomy, the variations in time and ...

IN 1979 Rothman et al.¹ reported an estimated 80 per cent increase in the prevalence of congenital heart disease among offspring of women who recalled use in early pregnancy of Bendectin, an antinausea preparation containing doxylamine succinate, ...

MONONUCLEAR-cell infiltration is the hallmark of the histologic process affecting the pancreatic islets in insulin-dependent diabetes mellitus (IDDM). Florid insulitis has mainly been detected close to the time of diagnosis, and its description¹ suggested ...

A LARGE literature has documented elevated death rates in lower social classes in the United States^{1 2 3 4} and elsewhere.⁵ These studies have primarily examined mortality in infants,^{1 , 2} adults,³ or total populations,^{4 , 5} rarely exploring the continuum ...

ACUTE fatty liver of pregnancy is a potentially fatal, uncommon disorder that may complicate the third trimester of pregnancy. If unrecognized or untreated, the disorder may progress to fulminant hepatic failure with jaundice, encephalopathy, disseminated ...

OPTIONS for the treatment of thoracoabdominally conjoined twins are largely dependent on the anatomy of the cardiovascular system.^{1 2 3} The extent of the conjunction of the heart and the severity of the associated cardiac defects primarily determine the ...

Presentation of Case

A 35-year-old woman was admitted to the hospital because of repeated bouts of pneumothorax, hemoptysis, and hemothorax.

She was well until 17 months earlier, when a spontaneous left hemothorax developed. She entered another hospital, ...

Fuchs, in his provocative book Who Shall Live,¹ estimates that the presence or absence of medical care accounts for only 10 per cent of the differences in mortality between different populations. Genetics, health habits, and that vague, yet powerful ...

To the Editor: On March 2, 1985, the Food and Drug Administration issued the first license for an enzyme-linked immunosorbent assay (EIA) for antibody to human T-cell lymphotropic virus, Type III (HTLV-III). Testing was begun immediately in American Red ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In his editorial on the treatment of hyponatremia (April 25 issue),* Dr. Schrier mentions hypovolemia as a stimulus for secretion of antidiuretic hormone. Although this is true of the mechanisms underlying hypersecretion of antidiuretic ...

To the Editor: In a 1981 report, Larson and colleagues¹ surveyed 123 psychiatric patients who underwent CT scanning of the brain; they found that 6 patients had "true positive" studies, all of whom had concurrent focal neurologic signs. Another 81 ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The purpose of this volume, in the editors' words, is "to identify the issues and themes around which debates about health policy will focus in the 1980s and beyond." In pursuit of these issues and themes, the volume takes the reader on an ambitious ...

No extract is available for articles shorter than 400 words.

This is a well-organized and carefully reasoned critique of the current state of American science and technology. It is particularly concerned with understanding the causes of the decline in the position of the American technological enterprise vis-à-vis ...

Case studies have long been used in health-services research to analyze the development of specific delivery systems and of government- or employer-funded health-benefit programs. Less common are microstudies that have examined patterns of change in local ...

The social history of Canadian medicine is poorly documented. Hamowy notes that most of the source material has been written by physicians reflecting an establishment position. Here are two books written by nonphysicians, both of them authoritative ...

Living is risky, and ours is historically an era of unprecedentedly low risk. Precious little has been written on understanding risks. We can calculate the risk of lung cancer for a smoker or that of an auto accident for an adolescent, but we do not ...

If understanding our past efforts to control sexually transmitted diseases can assist us in future attempts, publication of this book is timely. It is rendered especially so by the current acquired immunodeficiency syndrome (AIDS) epidemic. Brandt's book ...

When the Supreme Court re-legalized abortion in 1973, Justice Harry Blackmun called the Hippocratic oath "a Pythagorean manifesto and not the expression of an absolute standard of medical conduct." Here is a book that attempts a comprehensive survey of ...

No extract is available for articles shorter than 400 words.

The endless struggle that has long engaged the medical-research community and animal-welfare advocates over the use of animals in research has entered a new era of intensity. Signs of the struggle abound in federal and state legislatures, in a wave of ...