IN March 1983, the Commissioner of the Texas Department of Health requested assistance from the Centers for Disease Control in evaluating an apparent increased incidence of mortality in the pediatric intensive care unit at a large medical center hospital ...

ON March 25, 1981, a nurse employed on the cardiology service of a children's hospital in Toronto, Canada, was arrested and accused of administering overdoses of digoxin to four patients who had died during the preceding three months. Unusually high ...

OLDER but active patients with symptomatic angina pectoris constitute an expanding category in the United States population, and the number of coronary bypass surgical procedures performed in this age group has increased markedly during the past decade.^{1 ,...}

APART from classical, congenital adrenal hyperplasia due to complete or severe 21-hydroxylase deficiency, which is responsible for sexual ambiguity at birth and may be accompanied by salt loss, nonclassical, late-onset forms of adrenal hyperplasia have ...

GLUCOSE is an optional fuel for tissues such as muscle, fat, and liver that can also use fatty acids and other substrates to satisfy their energy needs. However, glucose is an obligate fuel for the central nervous system, since under physiologic ...

SEX differentiation in mammals, including human beings, is poorly understood. Although the Y chromosome is the usual stimulus for male sexual differentiation, the existence of fertile chromosomally normal XX males in goats demonstrates the importance of ...

RAPIDLY growing tumor cells depend on a high rate of pyrimidine synthesis for the generation of RNA and DNA. Fluorouracil is a pyrimidine-base analogue that acts as an antimetabolite to block the synthesis of deoxythymidylic acid and to disrupt normal RNA ...

Presentation of Case

A 52-year-old woman was admitted to the hospital because of progressive neurologic deterioration.

She was well until several years earlier, when she became increasingly irritable. Five years before admission psychotherapy was ...

Hospitals are remarkably successful institutions for reducing illness and preventing death. For some patients, however, danger lurks inside the hospital doors.

The greatest risk that the hospital environment presents to the patient is that of infection. ...

From the time of the first studies of human sex-chromosome anomalies it has been clear that sex determination in human beings is largely a function of the presence or absence of a Y chromosome; the Y chromosome is both necessary and sufficient for male ...

Host factors that cause large differences in rates of drug metabolism include genetic constitution, age, and dietary habits; hepatic, renal, cardiovascular, and endocrine function; and exposure to other drugs and chemicals, such as oral contraceptive ...

No extract is available for articles shorter than 400 words.

To the Editor: The development of effective therapeutic strategies based on in vitro pharmacologic data is fraught with difficulty, and this may be especially true in the case of putative "immunomodulators" such as cimetidine. In their report in the ...

To the Editor: The risk of HTLV-III seroconversion in health-care workers sustaining a needle-stick injury while caring for patients with AIDS appears to be low.^{1 , 2} There is only one report of seroconversion after a needle stick, which involved the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Elevation of the serum concentration of thyroid-stimulating hormone (TSH) is a sensitive indicator of primary hypothyroidism. Reports from European centers have shown that heterophilic antibodies neutralizing the rabbit antihuman TSH serum ...

To the Editor: In the January 24 issue, Valenta and co-workers¹ reported on a case of short stature with normal levels of both growth hormone and somatomedin C, in which a structural abnormality of the circulating growth hormone was detected. We report ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

When I was given a diagnosis of cancer, my first thought was not, Will I die? but rather, How can I beat this? Like a youngster who flunks a big test, I immediately began to worry about what to do to pass the course. I was 32 years old at the time, a ...

Like automobiles, medical textbooks have a variety of makes, styles, and accessories to appeal to the different tastes of physicians. This textbook is distinctly British in style. It is crisp, the format is clean, and the content is reserved. By any ...

This book is a history of our understanding of hepatology from ancient times to the present. Whereas ancient man believed that the liver was "the seat of the soul," modern man has gradually taken a more dispassionate view of this largest of the internal ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

NIH CONSENSUS PANEL REPORT

The National Institutes of Health will make available a report of a Consensus Development Conference on Health Implications of Obesity. Single copies of the report are available free of charge.

Contact Michael J. Bernstein, ...