RECENT studies indicate a close association between chronic myelocytic leukemia (CML) and the activation of an oncogene, human c-abl. The hallmark of CML is the presence of an abnormal chromosome, the Philadelphia (Ph¹) chromosome, found in the leukemic ...

DESPITE intensive study,^{1 2 3 4 5 6 7 8 9 10 11 12} the factors responsible for the development of severe diabetic retinopathy remain unknown, and no overall mechanism for its initiation and progression has emerged.

In 1978 a case–control study of diabetic ...

LIMITED information has been published on the survival of persons with chronic eye diseases. The available information on survival in patients with cataract, for example, is derived from special groups, such as those listed in blindness registers, insured ...

AMBULATORY electrocardiographic (ECG) monitoring is used routinely to detect and quantify ventricular arrhythmias. It has been employed in a variety of clinical situations to identify patients at high risk for sudden cardiac death, especially after ...

IN one simple form of experiment or observational study, the investigator compares sets of measurements taken from two groups to decide whether the group means differ. Emerson and Colditz¹ have reported that the t-test, the standard analysis for such an ...

BINGE—PURGE eating behavior is characteristic of two major eating disorders: anorexia nervosa and the more recently described syndrome of bulimia nervosa. Patients with these disorders rapidly consume foods with a high caloric content, then purge ...

CYSTINOSIS is a rare autosomal recessive metabolic disorder of children and adults, characterized biochemically by intracellular accumulation of free, nonprotein cystine crystals in the reticuloendothelial system, as well as in different tissues of the ...

Presentation of Case

A 25-year-old man was admitted to the hospital because of headache and fever.

He was well until 20 months earlier, when he noticed the gradual development of dysesthesia on the ulnar surface of the left hand and forearm and ...

Cystinosis is a recessively inherited disorder characterized by an accumulation of free cystine within lysosomes. The lysosome is a major site of intracellular protein degradation, which results in the release of free amino acids that must pass through ...

The practice of medicine has entered a new phase of patient "consumerism" and has, fortunately, emerged from the days of strict physician paternalism. This welcome trend places new emphasis on the role of patients in decision making and the right of ...

To the Editor: In the absence of either effective treatment or effective vaccines, reducing transmission-related behavior is the most practical means of trying to control the acquired immunodeficiency syndrome (AIDS) epidemic. Intravenous drug users ...

No extract is available for articles shorter than 400 words.

To the Editor: Calcium-channel blockers, specifically verapamil, have been shown in animal studies to protect the kidneys against long-term damage after an ischemic insult consisting of an intra-arterial infusion of norepinephrine.¹ Similar studies have ...

To the Editor: Diagnostic phlebotomy is the most common invasive procedure a hospitalized patient must endure. In certain cases, including those requiring multiple blood samples over a short period (e.g., diabetic ketoacidosis and endocrine studies), the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We have seen a patient in whom treatment with demeclocycline for the syndrome of inappropriate secretion of antidiuretic hormone was evidently responsible for phosphate diabetes, and we suggest a similar mechanism for the case described by ...

To the Editor: Peritoneal-fluid eosinophilia in patients undergoing peritoneal dialysis occurs most commonly during the first weeks after surgical implantation of a peritoneal-dialysis catheter and initiation of dialysis.^{1 , 2} The cause is unknown. After ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Teenage and young-adult suicide rates among whites in the United States have increased 2.5-fold between 1960 and 1980. Discussions in the media suggest that the problem is centered in the urban and suburban middle class. But when the death ...

To the Editor: On March 21, 1985, 20 people died from police bullets in Uitenhage, Eastern Cape, South Africa. A number of other people were injured. The circumstances surrounding the shootings have been investigated by a Judicial Commission of Inquiry. ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The High Cost of Healing is a book that has the character of an introductory textbook on health services and community medicine, but that falls far short in its level of scholarship and interdisciplinary sophistication when contrasted with other ...

No extract is available for articles shorter than 400 words.

Adoptive immunotherapy is a treatment approach in which cells with antitumor reactivity are administered to a tumor-bearing host and mediate either directly or indirectly the regression of established tumor.^{1 2 3 4}In selected animal-tumor models the ...