MITRAL-valve prolapse is a common entity¹ that has been implicated in several cardiac syndromes, ranging from the nonspecific symptoms of atypical chest pain, anxiety, and palpitations² to more devastating manifestations, such as cerebral embolic events, ...

HEPATIC necrosis is fortunately a rare complication of halothane anesthesia. Although the incidence is 1 in 7000 persons exposed, it is associated with a 20 to 50 per cent mortality rate.^{1 2 3} Those at greatest risk for halothane hepatitis are obese women ...

EACH year, in the United States alone, acute myocardial infarction suddenly develops in over 600,000 persons who are completely free of cardiac symptoms or only mildly symptomatic with stable angina pectoris.¹ Despite the frequency and severity of ...

THE lupus anticoagulant, an immunoglobulin acquired by some patients with systemic lupus erythematosus, prolongs phospholipid-dependent coagulation times but is paradoxically associated with an increased risk of thrombotic episodes.¹ In women, the ...

Herpes Simplex Virus Infections

DURING the past decade, genital herpes simplex virus infections have attracted increasing attention because of their prevalence, the alarm associated with a chronically recurring disease, the risk of transmission to sexual ...

IN the past 25 years there has been tremendous growth in our understanding of the renin–angiotensin–aldosterone system and of related intrarenal mechanisms for regulating electrolyte balance and blood pressure. Moreover, exciting new research now ...

Presentation of Case

A 60-year-old woman was admitted to the hospital because of chronic diarrhea and weight loss.

She was in a stable state of health until six months earlier, when her usual intermittent mild constipation was replaced by diarrhea that ...

Absolute documentation of the entity labeled halothane hepatitis remains impossible at best, and delineation of its pathogenesis is as will-o'-the-wispish as ever. A variety of causative mechanisms have been suggested over the years on the basis of ...

The so-called lupus anticoagulant is an antibody (IgG or IgM or both) that prolongs phospholipid-dependent coagulation tests by binding to epitopes on the phospholipid portion of prothrombinase (a complex of factor Xa, factor Va, phospholipid, and calcium)...

To the Editor: The paper by Lockshin et al. (July 18 issue)¹ on the presence of anticardiolipin antibody and the outcome of pregnancy in women with systemic lupus erythematosus raises important issues. The association between anticardiolipin antibody and ...

No extract is available for articles shorter than 400 words.

To the Editor: We wish to present a report of a pregnancy in which fertilization of an ovum obtained from a woman who had had a hysterectomy was followed by transfer of the embryo to a surrogate.

A 37-year-old woman had undergone bilateral salpingectomy ...

To the Editor: Fairly precise figures for the number of cases of the acquired immunodeficiency syndrome (AIDS) in the United States are based on surveillance data gathered by the Centers for Disease Control. Since the presence of antibodies to human T-...

To the Editor: Several recent reports have documented the presence of specific antibody to lymphadenopathy-associated virus/human T-cell lymphotropic virus Type III (LAV/HTLV-III) in serum collected in central Africa as early as 1972.¹ These studies have ...

No extract is available for articles shorter than 400 words.

To the Editor: The data reported by Cassileth et al. (June 13 issue)¹ provide potentially valuable information on the importance of psychosocial factors in surviving advanced malignant disease. I do not agree, however, that this study supports the ...

To the Editor: As past-president, president, and president-elect of the Society of Behavioral Medicine, we have several concerns regarding the recent editorial by Dr. Angell (June 13 issue)¹ that relate to her belief that "The evidence for mental state ...

This enjoyable book deals with an important and interesting subject — the perception and treatment of pain. Pain has always been an important factor in motivating patients to seek medical care. Current attitudes toward pain grew not only from developments ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Here, Adriani, the editor-revisor, has commendably maintained the format and style of the original editions of this book. However, that format no longer offers the necessary depth and breadth of information accumulated during the 20 years since the third ...

It is indeed a pleasure to review this long-awaited textbook on hypotensive anesthesia. No one is more qualified than its editor to lead its contributors in this historic, scientific, and clinical account of hypotensive anesthesia. In fact, Dr. Enderby ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Biomedical Science

Advances In Biotechnological Processes. Vol. 4. Edited by Avshalom Mizrahi and Antonius L. van Wezel. 356 pp., illustrated. New York, Alan R. Liss, 1985. $84.

Advances in Cancer Research. Vol. 44. Edited by George Klein and Sidney ...

HEALTH POLICY DOCTORAL PROGRAM

The Pew Doctoral Program in Health Policy of the University of Michigan is accepting applications for its second class, scheduled to begin in the fall of 1986.

Contact David Perlman, Pew Doctoral Program in Health Policy, ...

No extract is available for articles shorter than 400 words.

Over the past five years, there has been increasing support for the use of conservative surgery combined with radiotherapy as primary treatment for women with early breast cancer. This support is based on published reports from both retrospective studies,^...