TREATMENT for advanced breast cancer has been improved in recent years; combination or alternating chemotherapy frequently yields a response rate of 50 to 70 per cent, with a mean duration of response of 8 to 10 months.^{1 , 2} Endocrine therapy employed ...

FOUR subclasses of human IgG have been identified, each of which represents the product of a specific gene that encodes for the constant region of human immunoglobulin heavy chains. Subclasses of human IgG differ in their biologic activities. IgG1, IgG2, ...

VASECTOMY is one of the most common forms of male contraception throughout the world. More than half a million vasectomies are performed in the United States each year.¹ However, more vasectomy reversals are sought each year because of the increasing ...

DURING the past decade there have been major advances in the understanding of primary hemochromatosis. It is now widely accepted that hemochromatosis is inherited as an autosomal recessive disorder and that the gene frequency may be as high as 1:20.^{1 , 2} ...

MORTALITY data and statements of cause of death on death certificates continue to be used as the major sources of information characterizing the health of population groups.^{1 2 3} In the United States, mortality reporting has attained virtual completeness ...

CYTOMEGALOVIRUS and herpes simplex, varicella–zoster, and Epstein–Barr viruses, members of the herpesvirus family, are ubiquitous agents that infect almost all human beings at some point during their lives. Infections with these viruses have been found in ...

Presentation of Case

A 32-year-old woman was admitted to the hospital because of a cystic mass in the liver.

She was well until five months earlier, when diarrhea and fever developed and subsided after three days. Three months before admission she began ...

Interest in the effects of vasectomy on the male reproductive system goes back at least as far as 1823 and the observations of Sir Astley Cooper on the testes of his vasectomized dog.¹ Until the past two decades, however, reports of the effects of ...

Since 1923, when Wells challenged the reliability of existing cancer statistics,¹ over 100 publications documenting discrepancies (ranging from 20 to 40 per cent) between major clinical and autopsy diagnoses have repeatedly raised questions about the ...

Remunerating physicians on the basis of "usual, customary or reasonable" fees has led to abuses and contributed to the precipitous escalation of health care costs.¹ However, recent developments indicate that major changes are imminent. The Health Care ...

To the Editor: On the basis of their ability to inhibit viral reverse transcriptase, a number of chemotherapeutic agents are being tested in order to determine their potential efficacy in the treatment of the acquired immunodeficiency syndrome (AIDS) and ...

To the Editor: Each year more than 12 of every 100,000 youths between the ages of 15 and 24 commit suicide.¹ It is estimated that 5 to 15 times as many adolescents make suicide attempts each year. The actual prevalence of suicide attempts among ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: With the growing interest in the use of oral physostigmine for Alzheimer's disease,^{1 2 3} it is important to know the proportion of the dose reaching the circulation, since differences in response may be due in part to differences in ...

To the Editor: Pharmacologic attempts to reverse symptoms of Alzheimer's dementia have thus far lacked conspicuous success. Most recent therapeutic strategies have been designed to correct a cholinergic loss arising from degeneration of acetylcholine-...

No extract is available for articles shorter than 400 words.

To the Editor: Much has been written about the prognostic importance of "warning arrhythmias," particularly in regard to advanced forms of ventricular ectopy and their association with sudden death. This letter documents a new type of warning arrhythmia ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: I read the recent summary of changes in the financing of health care for the poor (July 4 issue)* with great interest. The author stated that the "federal government pays more for health care for the middle class and the wealthy than it ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Here, the editor states that he undertook this book to share with clinicians both factual knowledge and the "controversies and unanswered questions" concerning unstable angina so that clinicians can form rational plans for diagnosis and treatment.

The ...

Consumers of health care and their advocates have embraced the concept of informed consent, especially when surgery is involved. In an effort to provide "what every patient needs to know" about coronary artery bypass surgery, a cardiologist and a reporter ...

No extract is available for articles shorter than 400 words.

This volume covers a wide range of subjects, including the acquired immunodeficiency syndrome (AIDS), health problems of international travelers, viral infections of the gut and liver, infectious complications of particular surgical procedures, anaerobic ...

No extract is available for articles shorter than 400 words.

Several years ago, Volpé wrote a book on autoimmunity in the endocrine system. Now he admits that he cannot do it again without help. He has thus edited his own work and the work of 12 coauthors in this new book. Because of his long-standing interest in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

GERIATRIC MEDICINE

The first annual Symposium in Geriatric Medicine, sponsored by the Springfield Municipal Hospital and the Postgraduate Medical Institute, will be held at the Quality Inn in Chicopee, Mass., on November 20.

Contact Susan Kucharski, ...