X-LINKED hypophosphatemic osteomalacia (or rickets) is the prototypic vitamin D–resistant disease in human beings.^{1 , 2} It is characterized by hypophosphatemia, impaired renal tubular reabsorption of phosphate, and defective calcification of cartilage and ...

DEMENTIA is most commonly associated with Alzheimer's disease, a disorder with widespread social and economic implications. A distinction has often been made between presenile and senile forms of the disease, but since similar histologic changes are seen (...

AMONG Western European populations, genetic deficiency of the second component of complement (C2) is the most common complement-deficiency state.^{1 , 2} It occurs in approximately 1 in 10,000 white persons. Serum from patients with the deficiency lacks ...

BIOTINIDASE deficiency is an autosomal recessive disorder in which there is an inability to cleave biotin from biocytin or other biotinylated peptides resulting from the degradation of endogenous carboxylases and an inability, therefore, to recycle the ...

THE problem of controlling hospital costs is a major health policy concern. The rate of hospital cost inflation in 1982 (13.3 per cent) was more than three times the rate of increase in the consumer price index (3.9 per cent). These figures, combined with ...

In the process of training, the getting wind, as it is called, is largely a gradual increase in the capability of the heart.... The large heart of athletes may be due to the prolonged use of their muscles, but no man becomes a great runner or oarsman who ...

A NUMBER of recent reports have suggested that some patients with chronic fat malabsorption have spinocerebellar degeneration secondary to a severe and prolonged deficiency of vitamin E. The clinical features of this syndrome comprise progressive ataxia ...

Presentation of Case

A 38-year-old man was admitted to the hospital because of a rash and fever.

He was in excellent health until three days earlier, when he began his summer vacation in a lakeside cottage in rural Maine. That day he raked brush and ...

The latest addition to an enlarging list of inherited metabolic diseases that can be detected and effectively treated by means of programs of neonatal screening is described by Wolf and his colleagues in this issue of the Journal.¹ The authors have ...

The federal funding cuts in health care initiated in 1981 were meant to protect the truly needy while reversing the alarming upward spiral in costs. The cuts have been targeted at those on the margin of poverty and at providers. The combined effect has ...

To the Editor: During the investigational stage of the development of enzyme-linked immunosorbent assay (ELISA) kits for detection of antibodies to human T-cell lymphotropic virus Type III (HTLV-III), 15,368 plasma samples from random blood donors in the ...

To the Editor: Nyquil, a common over-the-counter cold remedy, has not been recognized as a cause of hepatic injury. Nyquil contains a combination of ephedrine, doxylamine, promethazine, dextromethorphan, and 700 mg of acetaminophen per ounce (30 ml) of a ...

No extract is available for articles shorter than 400 words.

To the Editor: Side effects of penicillamine are well known in patients treated for long periods.¹ They consist mainly of skin lesions, nephropathies, and sometimes depression of immunity. We report here a digestive complication.

A 58-year-old man had ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The Philadelphia chromosome (Ph), present in over 90 per cent of patients¹ with chronic myeloid leukemia, results when a small part of the long arm of chromosome 22 is replaced by a larger fragment derived from chromosome 9, containing the ...

No extract is available for articles shorter than 400 words.

To the Editor: Nathan Pritikin and the principles he publicized have been of interest to physicians for some time. His work has been discussed in many forums, including the Journal. Mr. Pritikin died in February 1985 at the age of 69, and we wish to ...

To the Editor: Fries has suggested that a decline in organ function with increasing age, rather than the cumulative effect of competing causes of mortality, limits the maximal human life span.¹ The function of the heart may be especially critical in this ...

To the Editor: I would like to add a cautionary footnote to Dr. Lesser's discussion of alexithymia in the March 14 issue.¹ Even as recently as four years ago, Lesser stated, "this new concept is being perceived as an established entity prematurely ...

To the Editor: As members of the pharmacy committee of a teaching hospital, we are concerned about the marketing practices of a few members of the pharmaceutical industry and fear that the possible success of these practices may encourage other companies ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

As Dr. Layzer points out in his preface, abnormalities of peripheral nerve, neuromuscular junction, and muscle are commonly the results of more general disturbances of electrolyte balance, endocrine function, and nutrition. They are also common ...

No extract is available for articles shorter than 400 words.

A decade ago, it was believed that after injury, neurons in the mammalian central nervous system were incapable of regeneration. They were considered unable to extend axonal outgrowth by more than a millimeter or two, and hence could not reform damaged ...

Since 1973, there have been many papers on the use of CT in the management of neurologic, ophthalmologic, otolaryngologic, and spinal lesions. There are still relatively few books available that summarize the CT findings in these diseases. Of the few ...

No extract is available for articles shorter than 400 words.

Computed tomography has become an essential tool for imaging several thoracic diseases. Its role in the staging of bronchogenic carcinoma, the evaluation of mediastinal masses, and the assessment of pleural abnormalities is well established. This ...

No extract is available for articles shorter than 400 words.

PHYSICIAN ASSISTANTS' PROGRAM

A program for physician assistants, entitled "Clinical Update '85," will be held at the Washington Convention Center in Washington, DC, August 22–. The fee is $180.

Contact the Conference Secretariat, PA Conferences, 9th Fl., ...

Mounting pressures on all levels of government to moderate the growth of their budgets and the movement to redefine medical care as an economic product rather than a social good are exacerbating the always difficult problem of financing care for people ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the June 1982 issue of the Annals of ...