CYSTIC fibrosis is the major cause of pancreatic insufficiency and respiratory failure in childhood. Almost all its pathologic features are related to obstruction of epithelial passages by thick secretions.¹ As early as 1933, Blackfan and Wolbach ...

BETWEEN 28 and 34 weeks of gestation, a switch in non-a-globin production — from predominantly γ-globin to β-globin — begins, and hemoglobin F (α₂ γ₂) is largely replaced by hemoglobin A (α₂ β₂).¹ This phenomenon ordinarily proceeds on an apparently set ...

RAPE is reported and prosecuted with increasing -frequency in the United States.¹ Detection of semen in vaginal fluid or other specimens from the rape victim may aid in documentation of sexual contact.² Semen can be conclusively demonstrated by the ...

CHOLERA is no stranger to the United States. Cases were identified in this country during four of the seven worldwide cholera pandemics that have occurred since 1817: over 150,000 Americans died in 1832 and 1849 when the protracted second cholera pandemic ...

BECAUSE of the central role of immunoglobulins in protection from bacterial infections, hypogammaglobulinemic states frequently result in serious infections with these organisms.¹ However, patients who do not produce normal amounts of immunoglobulin also ...

NUMEROUS drugs have been reported to initiate the development of specific anti-drug antibodies in some patients. When the patient is subsequently exposed to the drug, these antibodies may induce the formation of a drug–antibody complex, and to a variable ...

IN normal muscle, the principal sources of energy during exercise are glucose and fatty acids. The proportion of energy derived from each of these substrates depends on the intensity and duration of exercise.¹ Amino acids are known to serve two important ...

The Arizona Supreme Court recently reviewed a case in order to clarify the law regarding the obligations of physicians and hospitals in rendering emergency care to indigent patients. The opinion could have far-reaching implications, not only for clinical ...

Presentation of Case

A 62-year-old woman was admitted to the hospital because of a question of pneumonia.

She was well until 19 months earlier, when she noticed a lump in the left breast. A mammographie study was reported to be negative. Five months ...

Few physicians have better deserved to be remembered in eponym than Brian McArdle of Guy's Hospital. In 1951 he described a young man with a lifelong history of exertional muscle pain and stiffness¹ — symptoms that previous physicians had dismissed as ...

Two items in this issue have some lessons to teach us about the social responsibilities of hospitals in a health care system now obsessed with cost control and increasingly influenced by economic competition. The first article is a Sounding Board ...

I would like to address what seems to me to be a very disturbing trend from my vantage point as a primary care internist in a relatively isolated rural area approximately two hours in any direction from a referral center. To illustrate my problem, I ...

To the Editor: Since the identification of the acquired immunodeficiency syndrome (AIDS) in sexually active homosexual men, questions have arisen regarding the possibility that an agent for AIDS may be transmissible through plasma-derived vaccines for ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This textbook of physiology has now been revised for the first time since its fourth edition appeared eight years ago. Although it is not a completely revised version of that edition, important changes have been made in the chapters on cellular and ...

A major theme of human biology is the inseparable relation between form and function. Medicine has no exclusive claim to this important idea; it is a principle of architecture and engineering and a fact of everyday life. Function dictates form, and form ...

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COMMON CLINICAL PROBLEMS

A course entitled "New Strategies for Common ...

ON November 7, 1983, Newsweek published a supplement on "Personal Health Care" prepared by the American Medical Association (AMA) with financial support from the magazine. "This special supplement," the text stated, "offers easily understandable ...