BOTH clinical and laboratory observations have supported an immunologic mechanism for hematopoietic suppression in aplastic anemia.¹ Clinically, a large proportion of bone-marrow transplantations between syngeneic twins that are performed because of ...

EPIDEMIOLOGIC data strongly suggest that the acquired immunodeficiency syndrome (AIDS) is caused by an infectious agent, most likely a virus, which is transmitted horizontally through intimate contact or by blood products.¹ The agent, human T-cell ...

MOST clinical and epidemiologic studies of hepatitis B virus (HBV) infection have been based on the immunochemical detection of hepatitis B viral surface antigen (HBsAg) and antibodies to the viral core (anti-HBc) and surface (anti-HBs) antigenic ...

long-standing hypertension is a frequent precursor of congestive heart failure. When heart failure occurs, the left ventricle is usually hypertrophied and dilated and indexes of systolic function, such as ejection fraction, are reduced. Treatment is aimed ...

HUMANITY has existed as a genus for about 2 million years, and our prehuman hominid ancestors, the australopithecines, appeared at least 4 million years ago (Table 1). This phase of evolutionary history made definitive contributions to our current genetic ...

LYSINURIC protein intolerance is an autosomal recessive defect of dibasic amino acid transport.^{1 , 2} Renal tubular, intestinal, and hepatocellular transport is deficient, resulting in decreased circulating dibasic amino acid levels and a lack of ...

COMPELLING evidence implicates human T-cell lymphotropic virus Type III (HTLV-III) as the etiologic agent of the acquired immunodeficiency syndrome (AIDS).^{1 2 3} HTLV-III has also been associated with a syndrome of persistent lymphadenopathy and with mild ...

Presentation of Case

A 33-year-old woman was admitted to the hospital because of a question of a pituitary tumor.

She was well until one year earlier, when she began to experience fatigue and occasional hot flashes. Discomfort appeared in the anterior ...

Eight years ago, Hoffman and co-workers reported in the Journal that peripheral-blood lymphocytes from patients with aplastic anemia could suppress the growth of erythroid colonies from normal marrow.¹ Concurrently, it was shown that removal of ...

Our understanding of cardiac involvement in hypertension has developed remarkably over the past decade. The heart was traditionally viewed only as a target organ adapting to the increased pressure load by hypertrophy and eventually failing if the load ...

Ginzberg recently described in the Journal the monetarization of medical care.¹ Law follows money, and along with monetarization have come new laws and legal regulations — constraints that cast a lengthening shadow over the clinical practice of medicine. ...

Adzigian — Nazareth Adzigian, M.D., of Wellesley Hills, died on August 18 at the age of 69.

Dr. Adzigian received his degree from Tufts College Medical School in 1942. He was a member of the American Medical Association.

Bianco — Harvey H. Bianco, M.D., ...

No extract is available for articles shorter than 400 words.

To the Editor: The Bjork–Shiley 60-degree Convexo–Concave heart valve is one of the most widely used mechanical valve prostheses. It consists of two struts on either side of a convex–concave disk occluder. The inlet strut is integral to the valve ring, ...

No extract is available for articles shorter than 400 words.

To the Editor: Epidemiologic studies have suggested that cigarette smoking may be associated with an increased risk of cervical neoplasia, independent of sexual habits.^{1 2 3 4 5 6 7} The mechanism by which tobacco smoke could induce a genotoxic effect in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We wish to report a dramatic response to intravenous high-dose methylprednisolone in a patient with severe immune cold hemolysis, in whom conventional-dose steroid therapy failed.

This 42-year-old man had no remarkable previous disorders, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

As the 20th century nears its end, a backward look reveals the unfolding of a remarkable and tumultuous outpouring of change in our understanding of the biologic events governing life, the social organizations ruling medicine, and the technologic ...

No extract is available for articles shorter than 400 words.

This book tells about the experience of British physicians with sophisticated means of recording clinical data and leads us into the computer era. It is a scholarly work, rife with references and historical data.

The author shows how the microcomputer can ...

Because of widespread concern about a "capital crisis" in the hospital industry, the authors were commissioned by one of the foundations in 1981 to study the matter. Their analysis, embodied in this slim volume, examines three questions: Is there a ...

No extract is available for articles shorter than 400 words.

Rodney Maingot would be pleased with this eighth edition of his textbook. Although it carries his name, it clearly bears the stamp of the present editors, who wrote over a quarter of the book. Many other experts (drawn chiefly from Great Britain and ...

In a market surfeited with reference works on general surgery, one might ask why yet another textbook is necessary. Here, the editors have justified their new work by addressing a specific audience: practicing general surgeons. The stated objectives are ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The author is to be congratulated on producing this definitive book on gastrointestinal endoscopic interpretation. As with other books on gastrointestinal endoscopy, this one explains how to perform the procedure, although that is not the goal of the ...

Any orthopedic textbook that opens with the quotation from Henry Ford, "History is bunk," deserves further attention, if only to be sure that it lives up to the promise of its opening. Happily for the reader, this textbook does indeed sustain a high level ...

The cornea has apparently come into its own. Several full-sized textbooks devoted to this square centimeter of the body's surface have now appeared. This book is a welcome if somewhat atypical addition. Its organization is an admixture of anatomic, ...

Biomedical Science

Advances in Cancer Research. Vol. 41–1984. Edited by George Klein and Sidney Weinhouse. 383 pp., illustrated. Orlando, Fla., Academic Press, 1984. $49.

Advances in Cancer Research. Vol. 42–1984. Edited by George Klein and Sidney ...

CANCER CONFERENCE

A symposium entitled "Cancer Treatment 1985: Innovative Chemotherapy and Monoclonal Antibody Techniques" will be held at Overlook Hospital in Summit, N.J., on February 8. The fee is $50.

Contact C. Griffith, Dept. of Medical Education, ...