An attractive therapeutic target of monoclonal antibodies is the surface immunoglobulin of B-cell lymphomas or leukemias. Here, the neoplastic cells produce a tumor-specific molecular marker expressed as a unique variable (V) region and idiotype in their ...

Individual mature B cells exhibit surface-immunoglobulin molecules that contain only one type of variable region for the heavy chains and one for the light chains. This feature of normal B lymphocytes is shared by the neoplastic cells of most human B-cell ...

Coronary artery bypass surgery is a common form of treatment for coronary artery disease. An estimated 191,000 persons underwent the procedure¹ in 1983. Patients seeking relief from severe angina can be treated effectively with surgery, given suitable ...

Systemic lupus erythematosus (SLE) represents a spectrum of autoimmune disorders manifested through various constellations of signs, symptoms, and physical and laboratory-detected abnormalities. SLE thus represents the final common pathway for a number of ...

Ever since the report by Davies¹ in 1962 that 7 of 93 hospitalized alcoholic patients were able to return to "normal drinking" several years after treatment for alcoholism, the possibility of moderate drinking by former alcoholics has been highly ...

Human beings are the only reservoir for the gonococcus. In spite of public health efforts to control this pathogen, and the availability of adequate antibiotic therapy for 40 years, close to a million cases of gonococcal infection are reported in the ...

Presentation of Case

A 43-year-old woman was admitted to the hospital because of a progressive saddle-nose deformity.

She was well until 10 years earlier, when she began to notice a gradual decrease in prominence of the nasal bridge. Two years later ...

It was during the busy Christmas season when I turned my car into the parking lot of the funeral home. This patient was my third to die in the past few weeks, and tonight was my second wake in three days.

It was not easy to make the stop that evening. The ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Cocaine use is becoming an increasingly frequent problem in the United States. Cocaine has been gaining popularity on the street faster than any other drug.¹ A number of studies suggest that the adverse effects of cocaine are rare and ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The article by Warner on smoking and advertising (Feb. 7 issue)¹ correctly points out the news media's blatant disregard for truth regarding the hazards of cigarette use in exchange for huge revenues from tobacco advertising. But as a ...

President Reagan assured us that a major objective in invading Grenada was to close the St. George's Medical School (although Russians, Democrats, and M. Mitterand attributed to him more sinister motives). Lingering doubts about his sincerity were ...

Medical students and residents devote a fair amount of time to seeking out information. It is a process referred to as a "paper chase" or "going to the literature." This effort yields factual material relevant to the case or problem at hand, which is ...

This book opens with a summary of the political, economic, demographic, and ethical factors that influence the allocation of medical, educational, and social resources to care for chronically disabled children. The biologic, social, and emotional changes ...

No extract is available for articles shorter than 400 words.

There are few clinical books about a single disease that can capture the essential aspects of a disorder while developing both a broad and focused perspective. Perhaps cystic fibrosis lends itself to this kind of exposition. The editor of this ...

Although major advances have been made in the diagnosis and treatment of congenital heart disease in the past two decades, little progress has been made in understanding what causes these disorders or how to prevent them. Various chromosomal anomalies (...

No extract is available for articles shorter than 400 words.

ILLNESS BEHAVIOR

The Second International Conference on Illness Behavior will be held at Roy Thomson Hall in Toronto, Ont., August 14–16.

Contact IBC, c/o Gut Behavior Unit, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; or call (...