MUCH interest currently centers on whether otitis media occurring during early life may result in lasting developmental impairment.^{1 2 3 4} Disorders of speech, language, cognition, and behavior have all been attributed to early otitis media, the presumed ...

ISOLATED gonadotropin deficiency usually results from an inherited deficiency of hypothalamic secretion of gonadotropin-releasing hormone (GnRH). It is manifested by the absence of pubertal development and may be associated with other abnormalities, such ...

THE contribution of heritable factors to the genesis of colorectal cancer is not well understood.^{1 , 2} Although colorectal cancer occurs in well-defined inherited syndromes such as Gardner's syndrome, colonic familial polyposis, and cancer family syndrome,...

HYPERLIPIDEMIA is characteristic of the nephrotic syndrome. Elevated plasma levels of both total cholesterol and triglycerides have long been noted in patients with nephrosis.¹ However, there has been considerable debate about whether the hyperlipidemia ...

It may be difficult to estimate how much of the hardness and firmness is due to the tension of the blood within the vessel and how much to the thickening of the wall. If, for example, when the radial artery is compressed with the index finger the artery ...

IN the past few decades, numerous studies have reported a relation between psychosocial factors and the cause or course of malignant disease. These investigations are reviewed by Fox,^{1 , 2} who also details the many contradictory results and the ...

THE syndrome of postpartum renal failure, recognized since 1968, is an idiopathic condition characterized by renal failure in association with microangiopathic hemolytic anemia and, usually, thrombocytopenia occurring within a few days to approximately 10 ...

Presentation of Case

A 49-year-old man was admitted to the hospital after collapse at work.

He was reportedly well until three weeks earlier, when he fell and sustained a laceration of the right leg. A physician noted that his blood pressure was 150/90 mm ...

IT is currently thought that two distinct disorders are grouped under the general rubric of polyendocrine deficiency syndrome. The first disorder begins at a mean age of about 12 years and is characterized by the association of hypoparathyroidism, primary ...

The report of colon cancer in a family in Utah in this week's issue of the Journal ¹ brings up the question, What is a "cancer family"? Since one in four Americans has cancer in a lifetime, most readers will have some relatives with cancer, and some, by ...

Is cancer more likely in unhappy people? Can people who have cancer improve their chances of survival by learning to enjoy life and to think optimistically? What about heart attacks, peptic ulcers, asthma, rheumatoid arthritis, and inflammatory bowel ...

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To the Editor: The syndrome of generalized lymphadenopathy in homosexual men, or the lymphadenopathy syndrome, has been epidemiologically¹ and etiologically^{2 , 3} related to the acquired immunodeficiency syndrome (AIDS); in 0 to 19 per cent of patients ...

To the Editor: An inverted ratio of helper to suppressor T cells due to decreased numbers of helper T cells is found in patients with AIDS^{1 2 3} and in healthy but high-risk populations.^{4 5 6 7} The ratio itself has been used as a diagnostic aid. We have ...

To the Editor: Sharpe and Fields review the pathogenesis of viral infections, using reoviruses as a model (Feb. 21 issue).¹ Most mammalian viruses show some kind of cell or tissue specificity; this problem was addressed by Sharpe and Fields mainly from ...

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The necessity for attention to detail in gamete fertilization and culture of the human embryo in vitro is concisely described in this book. It is edited and primarily written by two of the foremost authorities on in vitro fertilization. Since the birth of ...

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Biomedical Science

Angiographic Anatomy of the Anterior Inferior Cerebellar Artery. (Advances in Anatomy, Embryology, and Cell Biology. Vol. 92.) By Jan J. Heimans, Jaap Valk, and Anthony H.M. Lohman. 91 pp., illustrated. New York, Springer-Verlag, 1985. $...

CREUTZFELDT–JAKOB DISEASE IN PATIENTS WHO RECEIVED PITUITARY-DERIVED HUMAN GROWTH HORMONE

Rapidly progressive, fatal, degenerative neurologic disorders have recently been reported in three recipients of human growth hormone. In two recipients, a diagnosis ...

Freezing of live human embryos in cleavage stages was highlighted in the U.S. media a year or so ago when an American couple died in a plane crash, leaving an heir in the United States and two frozen human embryos in an infertility center in Melbourne, ...