Attempts to explain the decline in mortality from coronary heart disease in the United States since the mid-1960s have focused on two major areas: changes in risk factors and changes in medical treatment.

Changes in the prevalence of the major risk ...

Primary biliary cirrhosis, a chronic liver disease of unknown cause, is characterized by inflammation and necrosis of intrahepatic bile ducts, cholestasis, cirrhosis, and hepatic failure.¹ The primary pathologic event appears to be destruction of the ...

Currently, the treatment of choice for younger patients with severe aplastic anemia is a bone marrow transplant from an HLA-identical sibling. For patients with severe aplastic anemia who lack a suitable marrow donor, treatment usually involves ...

The onset of puberty is characterized by pulsatile secretion of gonadotropins, which is dependent in turn on the episodic release of hypothalamic gonado-tropin-releasing hormone (LHRH). The rhythmicity and duration of LHRH release are critical to optimal ...

Academic departments of medicine commonly find themselves confronted with declining revenues from both research activities and patient care. There are multiple reasons: (1) Many departments, developed through research funding in parallel with the ...

Despite its description over a century ago, Wernicke's encephalopathy continues to be underrecognized in both alcoholic and nonalcoholic populations. Recent studies suggest that Wernicke's encephalopathy is the most common neuropathological finding ...

Antibodies specific for capsular polysaccharides of Streptococcus pneumoniae enhance complement fixation via the classical pathway and thereby initiate the single most efficient mechanism for opsonization of these organisms.¹ Since most IgG antibodies ...

Presentation of Case

First admission. A 65-year-old man was admitted to the hospital because of renal failure.

He was in a stable state of health until three months earlier, when a routine laboratory examination showed microscopic hematuria. Evaluation ...

Since the late 1960s, death rates in the United States from coronary heart disease have fallen steadily and markedly. This decline has involved all sectors of the adult population.^{1 , 2} For persons aged 35 to 74 years, the rate of mortality from coronary ...

Primary biliary cirrhosis has been a challenge to physicians since its initial description over 100 years ago. Over the years many observations have been published that have defined the disease more precisely, medical management of symptoms has improved, ...

Precocious sexual development is a stressful condition for both the affected child and the family.¹ Because of its relative rarity, numerous causes, and psychosocial complications, few other conditions pose as many diagnostic and therapeutic challenges. ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We would like to report on the successful treatment of amegakaryocytic thrombocytopenic purpura with cyclosporine. The patient was an 80-year-old woman who had been treated with radioiodide in 1979 for Graves' disease. In addition, because ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Altered calcium homeostasis may be important in the pathophysiology of aging^{1 , 2} (and Peterson C, Gibson GE: unpublished data) and Alzheimer's disease.^{3 4 5} At the molecular and cellular levels, Alzheimer's disease is associated with ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In 1959, the American Physiological Society embarked on the publication of the Handbook of Physiology. Modeled on the various German handbooks, it was divided into 11 sections, with one to seven volumes per section. Some of the volumes were divided into ...

The first of these two books is a collection of reviews on the basic mechanisms of central blood-pressure regulation, with a few chapters on the clinical effects of hypertension on the brain. Its stated purpose is to combine information related to ...

No extract is available for articles shorter than 400 words.

Although this book provides a broad overview of all aspects of cardiac angiography, it is not superficial, and the author manages to include a surprising amount of detail for a volume this size. Introductory chapters are devoted to history, a compact ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Biomedical Science

Absorption and Malabsorption of Mineral Nutrients. (Current Topics in Nutrition and Disease. Vol. 12.) Edited by Noel W. Solomons and Irwin H. Rosenberg. 314 pp. New York, Alan R. Liss, 1984. $66.

Adaptation to Altitude-Hypoxia in ...

DIAGNOSTIC ULTRASOUND

The Ninth Annual Spring Weekend Symposium in Diagnostic Ultrasound will be held at the Omni Park Central Hotel in New York, May 3–5. The fee is $400.

Contact Ms. Rosemarie Weber, Box 1198, Downstate Medical Ctr., 450 Clarkson Ave., ...