THE Leiden Intervention Trial is a study of the effect of lowering cholesterol on coronary artery atherosclerosis. Most previous studies have shown that serum total cholesterol can be lowered by changes in diet and by drugs, but have been inconclusive ...

THE diet-heart hypothesis has depended primarily on the role of dietary lipids in the development of atherosclerosis, and various types of studies have supported this hypothesis. Geographical studies have shown that consumption of saturated fatty acids is ...

CERTAIN cases of rheumatoid arthritis are refractory to conventional therapies because of lack of benefit or the occurrence of unacceptable side effects. The antimetabolite methotrexate was reported to produce favorable effects on rheumatoid arthritis by ...

VIGOROUS exercise is known to cause short-term elevations of the plasma potassium level in human beings.^{1 2 3} This "physiologic hyperkalemia" peaks with maximal exertion and is proportional to the amount of work done. When exercise stops, potassium levels ...

OVER the next several decades the practice of medicine in the United States will be increasingly influenced by the health care needs of our rapidly enlarging elderly population. Just as children are not merely young versions of adults, the elderly are not ...

PREGNANCY in women with chronic renal disease is accompanied by an increase in such complications as hypertension and proteinuria and by increases in prematurity and fetal loss. Although fertility is decreased in women with advanced renal insufficiency, ...

ACQUIRED immune hemolytic anemia can occur after exposure to a number of commonly used drugs. Among the best-documented offenders are penicillin, methyldopa, and quinidine, each of which is believed to act through a different mechanism.¹ Although ...

Presentation of Case

A 33-year-old woman was admitted to the hospital because of gangrenous toes.

There was a history of diabetes mellitus, Type I, with onset in her teens; complications included retinopathy that required laser treatment, peripheral ...

IN this issue of the Journal, a study of the composition of the diet found it to be a significant factor influencing mortality from coronary heart disease among Irish Bostonians as compared with their brothers in Ireland.¹ In a second study reported in ...

Many drugs currently used in the treatment of rheumatoid arthritis were originally suggested around 1950. The first clinical studies of antimalarial agents, alkylating agents, sulfasalazine, analogues of folic acid, and corticosteroids were performed ...

Recently, the U.S. Olympic Committee revealed that 7 members of its 24-member Olympic cycling team, including 4 medalists, had received blood transfusions in an effort to enhance their performance in the Los Angeles Olympic games. Ironically, public ...

To the Editor: Human T-cell lymphotropic virus Type III (HTLV-III), the causative agent of the acquired immunodeficiency syndrome (AIDS), has been isolated from blood, saliva, and semen^{1 2 3} but appears to be transmitted most efficiently among homosexual ...

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Bartzokas and colleagues (Nov. 29 issue)¹ describe an outbreak of colonization with methicillin-resistant Staphylococcus aureus in a vascular surgical unit. The authors attribute eradication of the organism to a vigorous program of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: During vigorous muscular activity normal subjects have a transient rise in plasma potassium. This physiologic hyperkalemia is augmented by β₂-blockade and reduced by β₂-receptor activation,^{1 , 2} which enhances the cellular reuptake of ...

No extract is available for articles shorter than 400 words.

To the Editor: In the July 26 issue, Nadi et al.¹ reported that primary cultures of human skin fibroblasts "possess muscarinic receptors with the properties of specific binding, saturability, pharmacologic specificity, inhibition of norepinephrine-...

To the Editor: The Sounding Board article by Dr. Moss (Nov. 22 issue)* neglects at least one dimension of the moonlighting problem. Today's residents and fellows are less able to care for the plethora of medical problems encountered in a community-...

To the Editor: Sandson (May 26, 1983, issue)* has indicated that there is a crisis in medical education caused by tuition increases and dwindling financial-aid resources. If current trends continue, he predicts, the mean debt of graduating medical ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Ultrasound physics and instrumentation remain mysteries to many. To lecture on them causes eyes to glaze over; to examine residents or registry candidates in them induces stark terror. But no longer: Diagnostic Ultrasound provides a clearly and engagingly ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The first of this pair is an anatomy book of the head and spine. It is not organized like the usual anatomy book. Instead, it is designed primarily for teaching CT and magnetic-resonance anatomy, with emphasis placed on three-dimensional concepts that ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

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MASSACHUSETTS GENERAL HOSPITAL

Harvard Medical School's Department of ...