Anecdotal information has been presented by the pioneers^{1 2 3 4 5 6} and more recent proponents^{7 8 9 10 11} of breast preservation for the management of primary breast cancer. Although they have not clearly determined the relative merits of such a ...

CURRENT controversy regarding the surgical treatment of primary breast cancer relates to the comparative merits of breast preservation and breast removal. A little more than a decade ago there was intense disagreement over whether the same outcome would ...

HEMOPHILIA A is an X-linked disease due to a deficiency of coagulation factor VIII, with a frequency of about 1 per 7000 to 10,000 male births. Substitution therapy usually allows one to avoid major hemorrhagic complications, but the treatment is the ...

PHYSICIANS and patients concerned about the health effects of toxic exposures need to know the chemical names of ambient substances in the work place and community. In the past, many industrial chemicals were identified only by trade names or codes, ...

PATIENTS who present with vague, ill-described physical symptoms often pose difficult problems for primary care physicians. Many of these patients have long histories of somatic symptoms and poor responses to standard medical treatment. Physicians often ...

IN the 12 years since its introduction into clinical trials in the United States, etoposide (VP-16–213; epipodophyllotoxin; 4′-demethyl-9-[4,6–0-ethylidene-D-glucopyranoside]) has been demonstrated to be active in the treatment of several neoplastic ...

NEUROPATHOLOGICAL studies during the past 15 years have established that dementia of the Alzheimer type, or Alzheimer's disease, is the most common cause of intellectual failure in the elderly, accounting for approximately 60 per cent of all cases of ...

Presentation of Case

A 54-year-old woman was admitted to the hospital because of a pancreatic mass.

She was well until six weeks earlier, when she began to experience persistent nausea and anorexia, with occasional vomiting of ingested food. She became ...

This issue of the Journal contains some results of two multicenter studies by the National Surgical Adjuvant Breast and Bowel Project,^{1 , 2} which go far toward defining a new rationale for surgical management of potentially curable breast cancer.

...

The cytoskeletons of all cells contain three ultrastructurally distinct elements made of fibrous macromolecules: microtubules 24 nm in diameter, intermediate filaments 10 nm in diameter, and microfilaments about 5 nm in diameter and composed of ...

No extract is available for articles shorter than 400 words.

To the Editor: The importance of the prevalence of the disease was not mentioned in the review of pheochromocytoma by Bravo and Gifford (Nov. 15 issue).¹ Although the prevalence of hypertension is high (15 to 20 per cent of the population),² the ...

To the Editor: Several neuropeptides have been implicated in the neuropathology of Alzheimer's disease.¹ The interaction of peptidergic systems, such as those involving somatostatin, with aminergic neurons also suggests that they may be involved in this ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Few discussions about disease have sparked as much controversy as that of pulmonary thromboembolism. Venous thromboembolism is probably the second most common major medical disease (after myocardial infarction), but its detection is hampered by a low ...

In 1962 Abramson edited a book entitled Blood Vessels and Lymphatics (New York: Academic Press, 1962), which was designed to "assemble, consolidate and interrelate" data on the development, structure, and function of the blood and lymph-related vascular ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

With such titles as the above, these two books will sell quite well.

The titles and much of the contents will only raise false hopes. The main purpose of this review is to sound a warning.

Unfortunately for the frightened public, scientific research has ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

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PSYCHOANALYTIC INSTITUTE OF NEW ENGLAND

The Institute will sponsor a program ...

As part of its effort to ensure the safety and efficacy of the pharmaceutical products that it certifies, the Food and Drug Administration systematically audits investigators and takes action against those who have engaged in scientific misconduct. The ...