THE increasing incidence of infections due to penicillinase-producing strains of Neisseria gonorrhoeae,¹ the recent emergence of spectinomycin-resistant strains,^{2 , 3} and the recognition of an increasing number of β-lactamase-negative isolates with high-...

ALUMINUM has been shown to accumulate in the bone of patients with renal failure.^{1 2 3 4 5 6 7} In our experience, accumulation of aluminum in bone can be found in 44 per cent of patients undergoing long-term dialysis.³ It is most frequently associated ...

DISTINCT α- and β-adrenergic receptors were first described by Ahlquist¹ over 30 years ago, on the basis of orders of potency of catecholamine agonists. Subsequent reports have described opposing a- and β-adrenergic influences on smooth-muscle tone,² ...

ALTHOUGH the association of insulin-dependent diabetes mellitus (IDDM) with certain histocompatibility antigens (HLA) demonstrates that genetic factors contribute to its causation, the exact role of heritable factors remains uncertain. A variety of single-...

THE elucidation of the molecular defect in Pompe's disease in 1963 led to the concept of lysosomal storage diseases. Since then, a number of inborn errors of metabolism have been shown to result in the accumulation of carbohydrate-containing compounds ...

SOME research studies, such as randomized clinical trials, make use of controls or comparison groups that are enrolled and followed simultaneously with the treated group and by the same investigators (internal controls), whereas others make use, perhaps ...

ELECTROCONVULSIVE therapy has become a national issue. Attacks on it have appeared in movies and television documentaries, as well as in the popular and professional press.^{1 , 2} These criticisms have resulted in legislation restricting its use in several ...

AMIODARONE, an iodine-containing benzofuran derivative, has been widely available in Europe for over 15 years, but its use in North America is still experimental. The drug has potent antiarrhythmic properties and has proved effective against a variety of ...

Presentation of Case

A 21-year-old man was admitted to the hospital because of fever and facial diplegia.

He was well until 10 days earlier, when he began to have a severe headache. Eight days before admission he sustained a severe sunburn of the dorsal ...

With the passage of the Medicare prospective-payment legislation¹ and issuance of the subsequent regulations,² hospital administrators (and to a lesser degree, physicians) have focused their attention on the question whether the current payment rales for ...

Non-A,non-B hepatitis was described just 10 years ago.^{1 , 2} The deliberately vague term "non-A,non-B hepatitis" was used because the agent or agents had not been identified. Ten years later, this term is still appropriate. The transmissible agent ...

To the Editor: The well-known cutaneous manifestations of the acquired immunodeficiency syndrome (AIDS), Kaposi's sarcoma, and progressive herpes simplex infection were recognized in the earliest descriptions of the syndrome.^{1 , 2} The otherwise extreme ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Prusiner's recent note on prions, amyloid, and Alzheimer's disease (March 8 issue)¹ asserts that "most cases of Alzheimer's and Creutzfeldt-Jakob disease are sporadic, but about 10 to 15 per cent are familial. The familial cases ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The idea that lymphomas and leukemias serve as monoclonal models for normal lymphocyte biology has considerable conceptual merit. Burkitt's tumor was the first lymphoma to be identified as a monoclonal B-cell neoplasm, in 1967.¹ Despite ...

To the Editor: A female patient had relapsing pure red-cell aplasia at the ages of 2 months, 6 years, and 19 years that was spontaneously reversible after, respectively, 3 months, 18 months, and 30 months of evolution.¹ At the age of 22, she had a ...

No extract is available for articles shorter than 400 words.

To the Editor: Two articles in the March 1 issue^{1 , 2} attempt to evaluate our asthma predictor index.³ There are important differences between these studies and our study. We found that careful standardization of patient evaluation was essential because ...

No extract is available for articles shorter than 400 words.

To the Editor: Mullane et al. have shown that 5-hydroxytryptamine and a THROMBOXANE A₂-mimetic agent potentiate the contractile effects of each other on canine coronary arteries.¹ Despite the potential clinical importance of such an interaction, direct ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: A new type of bathing suit has recently been released for sale this summer. Known as the Unsuit, it is made of 100 per cent cotton with a special weave that permits the ultraviolet "tanning" rays of the sun to penetrate. This allows the ...

No extract is available for articles shorter than 400 words.

Rather than describing and illustrating the neoplasms of each organ system, Toker has arranged 650 superb, large, black-and-white photomicrographs according to their histologic and cytologic features. The stated purpose of the book is "to provide a ...

As treatment of many pediatric cancers has improved in the last two decades, there has been a shift of attention to the family's adaptation. Treatment advances have allowed us to ask how one can best live with cancer. This book proposes to assist ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Nobody would deny the personal and socioeconomic destruction that can be caused by pain. A person who is disabled by pain costs society more than $21,000 annually, which means that if 2 per cent of the population in the United States were so afflicted, ...

No extract is available for articles shorter than 400 words.

As the population grows older and its members survive diseases that were formerly lethal, the science of gerontology finds new popularity among authors. Several recent works have attempted to present the aged as a separate subset of people with responses ...

No extract is available for articles shorter than 400 words.

RADIOLOGY

The University of Southern California will sponsor an annual radiology seminar at the Mauna Kea Beach Hotel in Hawaii, August 25-September 1.

Contact the Associate Dean, USC School of Medicine Postgraduate Div., 2025 Zonal Ave. KAM 307, Los ...

Relations between American hospitals and their medical staffs, increasingly troubled because of conflicting imperatives that society has imposed through its major agent of change — the federal government — will grow worse before they stand much chance of ...