CEREBROTENDINOUS xanthomatosis is a rare, recessively inherited lipid-storage disease that was first described^{1 , 2} in 1937. The major clinical features are tendon xanthomas, cataracts, dementia, pyramidal paresis, cerebellar ataxia, abnormalities on the ...

CYSTIC fibrosis, a disease involving widespread exocrine-gland dysfunction, is the most common lethal genetic disorder in North America, with an incidence of more than one case per 3700 live births.^{1 , 2} Death usually results from respiratory failure ...

FAMILIAL hypercholesterolemia is caused by mutations in the gene encoding the low-density-lipoprotein (LDL) receptor. This cell-surface receptor normally removes cholesterol-carrying LDL from the circulation.¹ Persons with two mutant LDL-receptor genes (...

INCREASED attention has been directed to the plight of disabled elderly patients being discharged from hospitals. One response has been the development of specialized geriatric evaluation and treatment programs. Initially patterned after models developed ...

MORE than 500,000 patients in the United States live with the aid of a permanent cardiac pacing system to ensure a dependable cardiac rhythm, and this year another 100,000 will undergo pacemaker implantation.¹ Now in its third decade, the field of cardiac ...

RIFAMPIN stimulates proliferation of the smooth endoplasmic reticulum of hepatocytes and induces microsomal enzymes involved in drug metabolism.¹ It was recently reported that concurrent administration of rifampin and ketoconazole resulted in decreases in ...

HYPERCALCEMIA has been reported to occur in association with several granulomatous disorders, including sarcoidosis, tuberculosis, fungal infections, and chronic beryllium disease.^{1 2 3 4} Recent reports suggest that extrarenal production of 1,25-...

Presentation of Case

An 86-year-old woman was admitted to the hospital because of facial swelling.

She was well until eight years earlier, when an IgA kappa M component was found at another hospital. Microscopical examination of an aspirated specimen of ...

Xanthomatosis typically occurs with hyperlipidemia, and tendon xanthomas are seen most commonly in familial hypercholesterolemia, a disorder associated with an increase in the plasma level of low-density lipoproteins. However, xanthomas are occasionally ...

There is little doubt that respiratory viruses contribute to the morbidity of patients with underlying pulmonary disease, such as chronic bronchitis, asthma, and cystic fibrosis. Indeed, the respiratory-virus season is often heralded by an increase in the ...

IN late 1978, the American Red Cross reported that the steadily increasing demand for thawed, deglycerolized human red cells had finally leveled off at its 57 regional blood centers, suppliers of over half the nation's blood for transfusion. The number ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Pentamidine isethionate is used in the treatment of P. carinii pneumonia, a common infection in patients with AIDS. Pentamidine has been supplied as an investigational drug to physicians in the United States by the Centers for Disease ...

To the Editor: A report by Hauser et al., which appeared in the Journal two years ago,* has been widely cited as a large-scale prospective study that demonstrated a low incidence of recurrent seizures (epilepsy) after an initial unprovoked seizure. Among ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Barbara Sicherman began doing research a decade ago for this biographical study of Alice Hamilton. At that time there was no reason to expect the recovery of a lifetime's output of letters or to imagine that the letters could lead to a "collaboration" ...

As a longtime devotee of Dupuytren, I have wondered why no biography of him has ever appeared in English. At last we have one, and it is excellent.

Although we remember Dupuytren chiefly for the hand condition that bears his name (in fact, Cline described ...

The purpose of this book is to inquire into the influence of Darwin, Marx, and Freud on ethical theory. The essays are introduced by the editors and organized in a three-part format with a principal essay on each of the three thinkers, each essay followed ...

This book is an amalgam consisting of a foreword by Norman Cousins (much of which is excerpted from a previously published commentary), a prologue by a former medical student now in training, two previously published papers by the consulting editor, ...

Using material from a period of five months spent in direct participation in the work of the Second Attached Hospital of the Hubei Provincial Medical College in Wuhan, the authors (a sociologist specializing in Chinese studies and a physician specializing ...

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AMERICAN SOCIETY OF CLINICAL PATHOLOGISTS

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