SMOKING has been widely recognized as a risk factor for coronary-artery disease and myocardial infarction. The many acute and chronic toxic effects of smoking also make it a possible etiologic agent in cardiomyopathy. The present study investigates ...

PROSTACYCLIN (prostaglandin I₂) and thromboxane A₂, the predominant cyclooxygenase metabolites of arachidonic acid in vascular endothelium and platelets, respectively, have potent and opposite effects on vascular tone and platelet function in vitro^{1 , 2} ...

TWO clinical signs are virtually pathognomonic of acute pericarditis¹: the pericardial rub and typical Stage I electrocardiographic changes — a nearly ubiquitous ST elevation in the absence of "early repolarization."² Yet, Stage I electrocardiographic ...

THE frequent development of marked hyperglycemia after an episode of insulin-induced hypoglycemia was first recognized in patients with insulin-dependent diabetes mellitus (IDDM) shortly after the introduction of insulin therapy more than 60 years ago.¹ ...

ACUTE lymphoblastic leukemia (ALL) is a hematologic malignant disease characterized by an uncontrolled proliferation of immature lymphocytes and their progenitors. Although ALL is most common in children, a substantial proportion of cases occur in ...

ENGEL and Angelini have reported that skeletal-muscle carnitine deficiency is associated with a lipid-storage myopathy.¹ Since then, two major clinical syndromes have been described²: a systemic form, in which carnitine concentrations are low in serum and ...

ANAPHYLACTIC or anaphylactoid attacks usually occur in immediate response to a specific inciting agent or event. Patients with recurring anaphylaxis in whom there is no evidence of an external cause are classified as having recurrent idiopathic ...

Presentation of Case

First admission. A 61-year-old man was admitted to the hospital because of oliguric renal failure

The patient was well until three weeks earlier, when he began to notice urinary frequency in small amounts. Five days before admission ...

Anaphylaxis, often explosive in onset, is one of the most serious emergencies in medical practice. It is usually attributed to the antigen-induced release of biologically active substances by IgE-sensitized mast cells, but identical clinical ...

Once upon a time we were merely the Community Hospital. That worthy institution was run by an Administrator who was helped by an Assistant Administrator and by a Chief of Nurses, Head Pharmacist, Director of Central Supply, and so forth. In those ...

IN the 1960s, health planning was primarily oriented to the issue of expanding access to medical care. In those days, grass-roots health planners were relatively oblivious to health-care economics and perverse health-system incentives. However, the ...

To the Editor: A third subtype of human T-cell lymphotropic viruses (HTLV-III) has recently been isolated from patients with the acquired immunodeficiency syndrome (AIDS).^{1 , 2} All American patients with AIDS and 84 per cent of those with lymphadenopathy ...

No extract is available for articles shorter than 400 words.

To the Editor: We were delighted to read the paper by Professors Mogensen and Christensen (July 12 issue)¹; not only do they now recognize the phenomenon of microalbuminuria² in established insulin-dependent diabetics (which Mogensen previously denied³) ...

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To the Editor: Levels of factor VIII–related antigen (VIIIR:Ag) and factor VIII activity (VIII:C) increase in stressful conditions, such as physical exercise,¹ and in respiratory failure due to the respiratory-distress syndrome in newborns² as well as in ...

To the Editor: The article by Phillips et al. (June 14 issue)¹ on the treatment of resistant malignant lymphoma by autologous bone-marrow transplantation was interesting, but the method is expensive, aggressive, and sometimes fatal. A team of specialists ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: It would appear that the Health Care Financing Administration (HCFA) anticipated the results and conclusions of the article by Wennberg et al. (Aug. 2 issue).¹ Recognizing that the use of diagnosis-related groups (DRGs) could exacerbate ...

No extract is available for articles shorter than 400 words.

The illness of a famous person, especially of a political leader, always fascinates the medical profession and lay public. The laryngeal cancer of Frederick III aroused enormous interest and discussion.¹ Frederick was a beloved German emperor with a ...

The ethical and social foundations of good physician–patient communications and their legal counterpart, the doctrine of informed consent, have been the subject of increasingly careful and abundant reflection. It is therefore somewhat surprising to ...

This gem of a book is at one and the same time an absorbing adventure story, a poetic evocation of a man struggling to become whole again, and a philosophical exegesis on the unity of body and mind. It affords such pleasure in the reading, because of the ...

As a family practitioner in a small clinic in Salinas, California, Dr. Clements became disturbed by the strange condition of some of his patients. Some were men who had been deliberately tortured with cigarette burns, others were women who had had their ...

In his brief life (1795–1821), John Keats managed both to study-medicine and to write some of the most memorable poetry in the English language. It has always surprised me that the part that medicine played in the creation of Keats' poetry should be so ...

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The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Pharmacology and Substance Abuse

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SEMINARS IN MEDICINE OF THE BETH ISRAEL HOSPITAL, BOSTON

The Hospital will ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.