OSTEOPETROSIS is a family of disorders caused by defective osteoclast function. The most severe expression of this condition is its malignant form, which is inherited as an autosomal recessive disorder. It is usually fatal before the second decade of ...

THE pathogenesis of minimal-change nephropathy remains unknown, although considerable indirect evidence suggests that it has an immune basis.^{1 , 2} The contention that minimal-change nephropathy is an immune disease is supported by its reliable response to ...

MULTIPLE myeloma, like other fatal diseases, is characterized by incidence and mortality rates that are similar. A dramatic rise in multiple myeloma's incidence and mortality over the past three decades has been reported in studies from the United States,^...

SEVERAL studies have demonstrated that during sleep patients with chronic obstructive pulmonary disease are prone to episodes of arterial oxygen desaturation, often to a profound degree.^{1 2 3 4 5 6} These episodes of hypoxemia are associated with nocturnal ...

A SUBSTANTIAL and growing body of evidence suggests that dietary factors may influence the incidence of human cancer.¹ Vitamin A, carotene, and vitamin E have received attention as nutrients that may reduce the occurrence of cancer. When fed to animals, ...

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OSMOREGULATION is markedly altered in normal human pregnancy. Osmotic thresholds for both thirst and secretion of arginine vasopressin decrease, and plasma osmolality and sodium levels are reduced by 10 mOsm per kilogram and 4 mmol per liter, respectively,...

Presentation of Case

A 34-year-old man was admitted to the hospital because of a progressive Central-nervous-system disorder.

The patient was born of an uneventful pregnancy and delivery and developed normally in his early years. At the age of 14 years he ...

Skeletal remodeling is an ongoing process of synthesis of bone matrix coupled with bone resorption, which is regulated by a variety of hormones and other factors. Bone formation and its regulation have recently been reviewed in the Journal.¹ Bone ...

Cyclophosphamide is a cytotoxic immunosuppressive and anticancer drug that has been used to treat a large variety of human disorders. It alkylates and phosphorylates important cellular macromolecules and preferentially kills cells that are rapidly ...

IN 1977 Miller et al. reported in the Journal that a single oral dose of prazosin could improve the altered hemodynamics of heart failure.¹ Among the desirable characteristics of this alpha-1-adrenergic blocking agent are its actions on both the ...

Donaldson — Gordon Alcock Donaldson, M.D., of Lincoln, died on September 7, at the age of 74.

Dr. Donaldson graduated from Harvard Medical School in 1935. He was a member of the American Medical Association, the American College of Surgeons, the Society ...

To the Editor: Because of the recently described occurrence of the acquired immunodeficiency syndrome (AIDS) in homosexual men, a large number of homosexual men with persistent unexplained lymphadenopathy are seeking medical attention.^{1 , 2} Many of these ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The letter by Ribera and Dutka in the September 8 issue¹ must be interpreted with caution. There is no conclusive evidence that the inflammatory polyradiculoneuropathies (IPNs) were a consequence of the hepatitis B vaccine. When a new ...

No extract is available for articles shorter than 400 words.

To the Editor: Somatostatin, a cyclic tetradecapeptide, has a wide spectrum of gastrointestinal actions, including inhibition of gastric and intestinal secretion, gut motility, pancreatic secretion, and hormone release.¹ Clinically, somatostatin has been ...

To the Editor: Recently, a partial deletion of the long arm of chromosome 16, del(16)(q22), was reported in patients with bone-marrow eosinophilia and acute nonlymphocytic leukemia.¹ Le Beau et al.² subsequently identified an apparently related ...

No extract is available for articles shorter than 400 words.

I remember when I was a senior resident working in the city-hospital emergency room. Another resident was on the telephone with the chief admitting resident. The conversation concerned a man with a previously known chronic organic brain syndrome and a ...

The specialization of the two cerebral hemispheres for different cognitive functions — verbal abilities in the left hemisphere of right-handed people, visuospatial functions in the right — is now widely recognized both in and outside of medical and ...

This small book is quite lively in style and fairly comprehensive. It covers neuropsychological views of the history of brain function. Its stated purpose is the introduction of the discipline of neuropsychology to "undergraduates, graduate clinical ...

A trend in teaching the nervous system to medical and beginning graduate students has been the integration of neurophysiology, neuropharmacology, and neuroanatomy into a single course in neuroscience. There are now several works that provide material for ...

Neuroscience is one of the most difficult and yet rewarding subjects that medical and graduate students encounter. This paradox challenges teachers to develop special approaches. Recently, several fine textbooks have appeared, each bearing the clear and ...

Davis and Maas have collected contributions from established researchers on the biochemistry, pathogenesis, and management of affective disorders.

The book is organized in two parts: "Symptomatology, Etiology and Epidemiology" and "Clinical Management and ...

Child psychiatry is coming of age. No longer do we assign our patients only to the two categories of adjustment reaction and hyperactivity. Instead, we recognize a variety of syndromes and base our diagnoses on operational criteria. One happy result is a ...

At present, there is a reexamination going on in the criminaljustice system. Much of it is conservative, like the mood of the nation. Statutory efforts at reform are quite extensive and include new capital-punishment laws, efforts to reduce the ...

Affecting approximately 200,000 people in the United States, multiple sclerosis is, as Scheinberg notes in his introduction, "After arthritis and trauma. . . the chief cause of major disability in adults of working age." A patient often requires the ...

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Biomedical Science

Advances in Human Genetics. Vol. 13. Edited by Harry Harris and Kurt Hirschhorn. 312 pp. New York, Plenum Press, 1983. $42.50.

Animal Models in Radiotracer Design. Edited by Richard M. Lambrecht and William C. Eckelman. 234 pp., ...

NUCLEAR resonance workshop

The European Workshop on Nuclear Resonance in Medicine will be held in Wiesbaden, West Germany, May 24–26. The fee is $260.

Contact Dr. Peter A. Rinck, European Workshop on Nuclear Magnetic Resonance in Medicine, P.O. Box 2149, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.