ANGIOEDEMAS can be classified as IgE-mediated, hypocomplementemic, or idiosyncratic.¹ More specific classifications include angioedema related to physical stimuli, such as pressure, and idiopathic varieties.² Eosinophilia in peripheral blood or tissue is ...

THE pathogenesis of allergic reactions involves the interaction of specific allergens and IgE antibodies hound to receptors on mast cells and basophils.¹ Bridging of IgE receptors on these cells leads to modification of the receptor and results in a ...

INFANTS with inborn errors of ureagenesis maintain normal plasma levels of ammonium and may have normal growth and development. Therapy relies on restriction of nitrogen intake, an abundant energy supply, activation of alternative pathways for waste-...

THE Mustard operation¹ for children with complete transposition of the great arteries has resulted in excellent short-term clinical and hemodynamic improvement; the long-term outcome, however, is unknown. Earlier reports have documented the important role ...

THE H2-receptor antagonist cimetidine is extensively used for the treatment of peptic-ulcer disease and other gastrointestinal disorders. Cimetidine has the additional pharmacologic property of impairing hepatic drug-oxidating capacity, leading to reduced ...

In attempting to arrive at the truth, I have applied everywhere for information, but in scarcely an instance have I been able to obtain hospital records fit for any purposes of comparison. If they could be obtained, they would enable us to decide many ...

THE United States Supreme Court is heavily involved, to its own discomfort and growing impatience, in reviewing a seemingly endless series of appeals in capital-punishment cases. The defendants wait in death rows while their lawyers process the appeals. ...

Presentation of Case

A 74-year-old man was admitted to the hospital because of wheezing.

There was a history of asthma since childhood, and a lengthy history of chronic obstructive pulmonary disease. The patient smoked cigarettes for approximately 25 ...

Recurrent angioedema is a particularly vexing problem for patients and clinicians alike, because over 90 per cent of chronic cases are "idiopathic" and therapy is often only palliative. Nevertheless, considerable information is available regarding several ...

In 1978, Breckenridge et al. described a patient with a deficiency of apolipoprotein C-II, the activator of the enzyme lipoprotein lipase.¹ It was predicted that the newly discovered disorder would provide additional understanding of the relation between ...

To the Editor: Cocaine blocks the uptake of endogenously secreted catecholamines¹ and has been associated with ventricular arrhythmia² and sudden death.³ It may also cause myocardial infarction through coronary-artery vasoconstriction, but a previously ...

To the Editor: In a clinical trial of timolol therapy for acute myocardial infarction, the International Collaborative Study Group has analyzed creatine kinase concentrations and electrocardiographic changes after infarction and concluded that treatment ...

To the Editor: As child-health educators working to encourage safe, effective methods of lice control, we take issue with the ideas expressed in Dr. Fine's letter in the December 8 issue.* His contentions that nit removal is "absolute nonsense" and that ...

To the Editor: The Food and Drug Administration's recent release of commercially manufactured alpha-fetoprotein-testing kits for fetal open neural-lube defects¹ climaxes nearly a decade of debate, confusion, and concern.^{2 , 3} There are two major problems ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Gwyn Macfarlane's splendid biography of Florey and the work of Oxford scientists on the development, production, and clinical trials of penicillin early in World War II aroused his interest in some of the puzzles of Fleming's career. This biography is a ...

The eradication of smallpox — officially certified in 1979 — constitutes one of the great triumphs of modern medicine and public health. Here, a physician and public-health official who participated in the Smallpox Eradication Program provides an overview ...

This book is about three men who worked in Paris between 1790 and 1858: Xavier Bichat, François Magendie, and Claude Bernard. The author considers them to have been responsible for the emergence of experimental physiology and thereby of modern medicine.

...

Scientists, policy-makers, and laymen alike could benefit from a book that examined in scholarly and unbiased fashion the substance of current biomedical-research policy in this country, the process by which policy is formed, and the nature and ...

No extract is available for articles shorter than 400 words.

Preferred-provider organizations (PPOs) are the most exciting new phenomenon to hit the health-care system in a long time — and the most oversold. Within the past six months, five books on PPOs have crossed my desk, each with different definitions, ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Addresses of most overseas publishers ...

NATIONAL INSTITUTES OF HEALTH CONSENSUS REPORTS

The NIH has issued reports on two Consensus Development Conferences held earlier this year: "Analgesic Associated Kidney Disease" and "The Use of Diagnostic Ultrasound Imaging in Pregnancy." Single copies of ...

Under the sponsorship of the Division of Lung Diseases of the National Heart, Lung, and Blood Institute, a two-day workshop on the pulmonary complications of the acquired immunodeficiency syndrome (AIDS) was held in Bethesda, Md., on October 13 and 14, ...