GENITAL infection with herpes simplex virus is an increasingly common problem, particularly in sexually active young adults and adolescents.¹ Acyclovir has recently been shown to be the first antiviral agent to decrease significantly the duration and ...

AFTER the first episode of genital herpes simplex virus infection, the major morbidity of the disease consists of frequent recurrent episodes and the risk of transmission to sexual partners and neonates.^{1 2 3 4} Although the long-term natural history of ...

COMBINATION chemotherapy produces complete remissions in most patients with disseminated Hodgkin's disease¹ or aggressive non-Hodgkin's lymphoma²; however, patients who do not obtain a remission or who relapse after primary chemotherapy have a poor ...

HEMOPHILUS INFLUENZAE type b is the most important cause of serious invasive infections in young children in industrialized countries^{1 2 3 4} and is also quite common in developing countries⁵; 20,000 to 30,000 cases are estimated to occur yearly in the ...

PATIENTS with hypertrophic obstructive cardiomyopathy are subject to syncope and sudden death.^{1 , 2} The mechanism is usually not defined but could include supraventricular tachyarrhythmias,³ bradyarrhythmias and heart block,⁴ acute myocardial infarction,⁵ ...

VIRTUALLY all hormones and drugs initiate their biologic actions by binding to specific cellular recognition sites, termed receptors. Receptor binding is followed by alterations of cellular metabolic events, such as enzyme activities or ion fluxes, that ...

SULFHEMOGLOBIN, methemoglobin, and the M hemoglobins must be considered when one is evaluating the cyanotic patient. Sulfhemoglobin is a green-pigmented molecule with a sulfur atom incorporated into the porphyrin ring and a markedly reduced oxygen ...

Presentation of Case

A 52-year-old man was admitted to the hospital because of pancytopenia and a question of enteric fever.

Three years earlier a cadaveric renal transplantation was performed at this hospital because of polycystic renal disease. He was ...

Infections due to Hemophilus influenzae are a major problem in people of all ages. In children, H. influenzae type b is the leading cause of meningitis, the primary cause of epiglottitis, and an important cause of arthritis, cellulitis, and pneumonia. The ...

Five years ago Toft and co-workers described their experience with propranolol for preoperative therapy in patients with hyperthyroidism due to Graves' disease.¹ The results were excellent in terms of amelioration of the clinical manifestations of ...

Medical decisions require both technical expertise and informed consent. They should be made jointly by physicians and patients. But when the patient is incapable of participating in decision making, what should the doctor do? This question haunts ...

To the Editor: In a recent report¹ and accompanying editorial² (Jan. 12 issue) on the association of the acquired immunodeficiency syndrome (AIDS) with blood transfusions, the issues of additional factors attributable to blood transfusions¹ and host ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Gennari has provided an excellent review of the clinical applications of serum osmolality (Jan. 12 issue).¹ However, some comment about the methods involved in several of the laboratory determinations seems warranted. Standard ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Despite recent advances in medical science, the poor health of many in the developing world remains a reality; more than hall the world's people do not have access even to basic health care. Providing basic biomedical services requires ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The Siegal and Siegal book is exciting and fact-filled, written by two professionals who are living through this unfolding saga. This excellent book is for physicians (generalists and specialists), and because of the extraordinary clarity of the ...

Although these two books differ superficially, particularly with respect to content, they have fundamental similarities. Both are multiauthored, clearly written, and well edited; both contain useful tables and illustrations; and neither is excessively ...

No extract is available for articles shorter than 400 words.

The determined efforts of a small group of talented and tenacious investigators, not discouraged by repeated early failures, have resulted in the development of a form of therapy that now provides hope for many young people with disorders that were ...

No extract is available for articles shorter than 400 words.

DIABETES

The New York Health Research Council will offer a limited number of postdoctoral fellowships and research grants for projects in the study of diabetes. Candidates must be affiliated or scheduled to be affiliated in 1984 with an institution in New ...

Public-opinion polls indicate that three quarters of the American public and a majority of hospital administrators, private-insurance executives, and corporate and labor-union purchasers of medical care believe that fundamental changes are needed in the ...