VITAMIN E (α-tocopherol) deficiency in children with chronic cholestatic hepatobiliary diseases has been associated with a progressive neurologic syndrome composed of cerebellar ataxia, posterior column dysfunction, and peripheral neuropathy. ^{1 , 2} Recent ...

CURRENT interest in the pharmacologic properties of heroin (3,6-diacetylmorphine) arise from its continued illicit use by drug abusers and from the proposed changes in regulations to permit its medical use for the relief of terminal cancer pain.¹ To date, ...

OXYGEN therapy decreases pulmonary-artery pressure¹ and hematocrit,² improves psychological function,³ and decreases mortality⁴ in patients with severe chronic obstructive pulmonary disease. It is generally recommended that patients with a resting ...

ALTHOUGH calcium is the principal regulator of parathyroid gland function, magnesium has also been observed to have an important role.¹ Both low and high concentrations of serum magnesium may directly affect the secretion of parathyroid hormone. Profound ...

THE Epstein–Barr virus (EBV) is present in saliva in most patients with infectious mononucleosis, in up to 20 per cent of healthy EBV antibody–positive persons,^{1 2 3 4} and in 50 per cent or more of seropositive patients receiving immunosuppressive drugs.⁵ ...

PROSPECTIVE payment is a cornerstone of federal and state plans to control health-care costs.¹ It is also perceived as a threat to the financial viability of academic medical centers, whose costs per admission exceed those of community hospitals.^{2 , 3} ...

THE presence of recurrent bacterial infections in a child raises the discomforting possibility of some type of underlying immunodeficiency disease. None of these diseases is common, and the money spent and blood withdrawn searching for them can be ...

INFECTION with filarial parasites (Wuchereria bancrofti, Brugia malayi, and B. timori) that dwell in the lymphatic system produces a range of manifestations, including elephantiasis,¹ which usually develops in adulthood. Related brugian filarial species, ...

Presentation of Case

First admission. A 50-year-old woman was admitted to the hospital because of unresolved pneumonia.

She was well until two years earlier, when rightsided pneumonia developed and resolved slowly on treatment. Three months before entry ...

Magnesium, the fourth most abundant metal in living organisms, is distributed in three major compartments in the body: 65 per cent in the mineral phase of skeleton, 34 per cent in the intracellular space, and only 1 per cent in the extracellular fluid.¹ ...

The biology of Epstein–Barr virus (EBV) is fascinating even to the casual observer. To a devotee like me, it is positively gripping. The virus has a variety of remarkable potentials, including the ability to cause normal lymphocytes to grow indefinitely ...

Everyone knows that teaching hospitals have greater expenses and charge more for their services than do nonteaching hospitals. In 1981, for example, the average cost of care, per adjusted admission, in the more than 300 major teaching hospitals belonging ...

To the Editor: My late husband, Phillip Signorini, was a member of the Christian Science church, and at various times he consulted a Christian Science practitioner.

When he was 40 years old, his glands enlarged and then increased gradually both in number ...

To the Editor: The careful study by Kilbourne and colleagues (Dec. 8 issue)¹ of the natural history of acute toxic-oil syndrome and its late severe neuromuscular sequelae made only one reference to the occurrence of pulmonary hypertension after the acute ...

To the Editor: Braunwald (Nov. 10 issue)¹ generalizes from the similarity in the survival of patients randomly assigned to either medical or surgical therapy in the Coronary-Artery Surgery Study (CASS)² to conclude that the annual mortality of all ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The X-linked gene coding for glucose-6-phosphate dehydrogenase (G6PD), because it is subject to the phenomenon of X-chromosome inactivation, has been used extensively as a "clonality marker"¹ in a variety of cell populations — for example, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

A book on the effects of low-dose irradiation on humankind is in a sense an artificial grouping of disparate topics. It may include some physics, some radiobiology, some curve-fitting, and a lot of speculation about philosophy and bioethics. The hook ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book provides a comprehensive discussion of the principles and applications of emission tomography. It is timely because the present surge of interest in nuclear magnetic resonance imaging and spectroscopy has drawn attention to the fact that disease ...

No extract is available for articles shorter than 400 words.

This unusual program consists of an audio portion presented on six sides of three tape cassettes, with a concomitant visual portion presented as 200 slide transparencies for projection.

The slide number being discussed is described by the commentator so ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Addresses of most overseas publishers ...

PEDIATRIC CARDIOLOGY

The Second World Congress of Pediatric Cardiology will be held at the Waldorf Astoria Hotel in New York, June 2–6.

Contact Virginia Herlitz, 404 Park Ave. S., New York, NY 10016.

FAMILY MEDICINE

The Medical University of South ...