RECENT studies of the influence of 5-azacytidine on the production of fetal hemoglobin in phlebotomized baboons¹ and in patients with beta-thalassemia or sickle-cell anemia^{2 , 3} have brought forth suggestions that hemoglobin regulation can be influenced ...

ACIDOSIS is known to impair the contractility of both cardiac^{1 2 3 4} and skeletal muscle,⁵ whereas alkalosis has the opposite effect on the heart.⁶ Fitzgerald and coauthors⁷ have demonstrated that acidosis due to acute hypercapnia or a reduction in the ...

SQUAMOUS-CELL neoplasia (including cancer precursors) of the uterine cervix is the most prevalent neoplasm affecting women. It is also one of the best-studied human neoplasms, and its epidemiology and natural history are well understood. It occurs most ...

ONE of the principal clinical expressions of the acquired immunodeficiency syndrome (AIDS), which clearly attests to the striking defect in these patients' cellular immune responses, is the development of serious, frequently fatal opportunistic ...

TRANSSPHENOIDAL pituitary microsurgery is a promising new approach to the management of Cushing's disease due to ACTH-secreting pituitary adenomas in adults.^{1 2 3} Cushing's syndrome and disease are rare in infancy and childhood⁴; however, when they do ...

RECENTLY, the Health Insurance Association of America (HIAA), which is the trade association for commercial health insurers, has mounted a campaign to Call attention to what it perceives as "cost shifting" in payment for hospital care.¹ Specifically, HIAA ...

PRIMARY sclerosing cholangitis, an uncommonly diagnosed syndrome of unknown cause, is characterized by chronic fibrosing inflammation of bile ducts, usually affecting both the extrahepatic and intrahepatic biliary ductal systems.^{1 , 2} The disease leads to ...

THE recurrence of leukemia in donor cells is a rare type of relapse after bone-marrow transplantation for acute leukemia, whether lymphoblastic or nonlymphoblastic. This phenomenon was first described in 1971,¹ and since then additional cases have been ...

Presentation of Case

A 29-year-old woman was admitted to the hospital because of increasing cough and dyspnea.

She was well until nine years earlier, when mild dyspnea and a chronic cough developed during her first pregnancy and gradually increased in ...

Worldwide, millions of peoples' lives are affected directly or indirectly by inherited abnormalities of the beta-globin chain. Most prominent among these abnormalities are sickle-cell anemia and beta-thalassemia (in which production of the beta-globin ...

An editorial appearing six years ago in the Journal ¹ pointed out the unresolved controversy between those who considered Cushing's disease to be the result of a primary neoplastic change of the pituitary corticotrope cells and those who believed that the ...

New legislation to provide Medicare reimbursement for hospice care¹ has created problems for physicians who are involved in the treatment of the terminally ill. Under current proposals,² hospice services will be reimbursed by a certain amount per patient ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the article by Van Vliet et al. (Oct. 27 issue) the effects of human growth hormone treatment are reported in short normal children.¹ Growth hormone doses were comparable to those used for therapy in hypopituitarism. The authors point ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: On the basis of pharmacokinetic data, Zimm et al.,¹ have questioned whether an optimal amount of mercaptopurine is currently being given in maintenance chemotherapy regimens for acute lymphoblastic leukemia (April 28, 1983, issue). They ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

As a result of general economic reforms in 1980, the Chinese rural health-care system is undergoing rapid transformation. Ironically, modernization has inadvertently caused a once viable model health system to crumble. The cooperative medical system with ...