PYRIDOXINE, an essential, water-soluble vitamin (B₆), is a coenzyme for many decarboxylation and transamination reactions; the minimum daily requirement for normal adults is 2 to 4 mg. It is generally held that "the water-soluble vitamins are among the ...

THE inborn errors of methionine metabolism that result in homocystinuria are of special interest, because, like homozygous familial hyperlipoproteinemia, they provide a model for premature atherogenesis in human beings. Homocystinuria has an incidence of ...

OVER the past two years, a new syndrome has been described that consists of severe opportunistic infections; the development of neoplasms, especially Kaposi's sarcoma; and profound abnormalities of cellular immune function in previously healthy persons.^{1 ...}

IDIOPATHIC thrombocytopenic purpura (ITP) is a syndrome of unknown origin consisting of persistent thrombocytopenia and purpura. Considerable evidence suggests that a circulating anti-platelet factor is responsible for accelerated platelet destruction, ...

OVER the past decade, the number of physicians in group practice has more than doubled, from 40,000 to 90,000, and the relative proportion of group to solo physicians has increased from one in five to one in three.¹ Because of this increased prevalence, ...

THE study of circadian (approximately 24-hour) rhythms has within the past decade evolved from a biologic curiosity to a science with enormous implications for clinical medicine. The concurrent maturation of circadian oscillator theory, the anatomic ...

Presentation of Case

A 32-year-old man was admitted to the hospital because of a question of metastatic testicular cancer.

He was well until four months earlier, when he noticed slight pain and swelling of the left testis, accompanied by a nonproductive ...

The medical use of vitamins, which began in the 18th century, can be divided into three eras: the prevention or treatment of diseases of deficiency, the treatment of vitamin-responsive inborn errors of metabolism, and the currently popular "orthomolecular"...

Between the years 1945 and 1951, two developments in the growing field of immunohematology were particularly critical. In 1945 Coombs et al. used a rabbit serum against human globulin to produce agglutination of red cells that had been sensitized by the ...

No extract is available for articles shorter than 400 words.

To the Editor: We wish to report another case of progressive multifocal leukoencephalopathy in the setting of the acquired immunodeficiency syndrome (AIDS).¹ A 31-year-old white man was admitted because of confusion, gait disturbance, and urinary ...

No extract is available for articles shorter than 400 words.

To the Editor: The cause of histiocytosis X is unknown, and although the disorder has certain features of neoplasia, the high incidence of spontaneous remission and the histology are against this. Osband et al. suggested that the disease was due to a ...

To the Editor: In two important articles in the March 10 issue of the Journal, Clowes et al.¹ and Baracos et al.² have provided evidence that one or more protein mediators may be responsible for the protein catabolic response to infection in skeletal ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The recent review of advances in abdominal surgery by Welch and Malt (March 17, 24, and 31 issues) is, as in past years, superb. As a radiologist I appreciate the chance to catch up on what my surgical colleagues are doing, and I am ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The format of this volume is similar to that of Current Surgical Management (Ellison, Friesen, and Mulholland), published in the late 1950s and early 1960s. It is a welcome sequel to that popular series of provocative debates on surgical therapy.

Change ...

The patient who will require a Whipple resection for a carcinoma of the pancreas and the multiply injured victim of a motorcycle accident both pose problems in nutritional support: When should support be started, should enteral or parenteral feeding be ...

No extract is available for articles shorter than 400 words.

Here is a major endeavor to provide an authoritative survey of surgical pathology and, at the same time, a useful reference work for the practicing pathologist and the trainee — a new work in an important area of medicine. It is worth examining the ...

Clinicians are often confronted with a pathology report on a critical specimen that reads: "Caseating/Necrotizing/Non-caseating [choose one] granulomas; no organisms or foreign material identified." The cause of granulomas remains a challenge to ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The information in this well-written book based largely on a long-term longitudinal study contradicts a large body of short-term research observations about the genesis of alcoholism. Dr. Vaillant concludes that the supposed premorbid antecedents of ...

No extract is available for articles shorter than 400 words.

"For in that time. . . at least a third of all the people in the world died," wrote Jean Froissart, a chronicler contemporary with the terrible pandemic of plague that swept Europe from 1348 to 1351. Although meant to echo the Bible, Froissart's estimate ...

The biomedical community is blessed with two writers of delightful essays. One, Lewis Thomas (Lives of a Cell, New York: Bantam Books, 1975; The Medusa and the Snail, New York: Viking Press, 1979), has just come out with a new book, The Youngest Science (...

Biomedical Science

Iron Metabolism. By Ivan Bernat. 415 pp., illustrated. New York, Plenum Press, 1983. $39.50.

Review of Medical Microbiology. By Abraham I. Braude and J. Allen McCutchan. 208 pp., illustrated. Philadelphia, W.B. Saunders, 1983. $14.50.

...

GENETICS SYMPOSIUM

A symposium entitled "Genetics and Environmental Influences on Disease and Development" will be held at the Vista Hotel in New York on September 25. The fee is $85.

Contact Leona J. Schumer, March of Dimes, 622 Third Ave., New York, NY ...

New forces on the political landscape, rooted largely in the economics of medical care, are pressing federal officials and private interests to develop more adequate mechanisms to assess the safety and efficacy of emerging medical technologies. One force ...