IDENTIFICATION of a lipoprotein or an apolipoprotein that could be used as both a sensitive and specific index for the presence or absence of coronary-artery disease has a high priority. There is considerable evidence, primarily from epidemiologic studies,...

LACTIC acidosis is a disorder of intermediary metabolism that is fatal in the majority of cases.¹ It is a common condition with a reported incidence of 1 per cent among unselected, consecutive admissions to a hospital.² Many illnesses precipitate the ...

PLATELET aggregation has been implicated in the pathogenesis of atherosclerosis and its complications.^{1 2 3} Aspirin inhibits cyclo-oxygenase and the second phase of platelet aggregation.^{2 , 4} These facts have prompted the hypothesis that aspirin may be ...

THE most enduring hypothesis concerning the origin of cancer is that some genetic alteration — induced by the environment, by predisposition, or by both factors acting in concert — results in the unregulated and remorseless proliferation of cells. ...

Clinical Use of Benzodiazepines

Anxiety

Since 1977, several new benzodiazepines have been marketed in the United States for the treatment of anxiety syndromes^{67 68 69 70 71} (Table 1). These drugs may offer some subtle clinical options. Prazepam, for ...

MALIGNANT hyperthermia was first described fully in 1962, when Denborough and colleagues reported an episode in a patient with a fear of anesthesia prompted by the death of 10 of 24 relatives who had received general anesthesia.¹ A genetic susceptibility ...

Presentation of Case

A 55-year-old woman was admitted to the hospital because of polyuria, bitemporal hemianopia, and a suprasellar mass.

She was well until two months earlier, when bronchitis developed, characterized by a nonproductive cough, fever, and ...

A strong, almost perfectly predictive association between apolipoprotein A-I levels and the presence of obstructive coronary-artery disease is reported by a Mayo Clinic group in this issue.¹ The report induces love at first sight, but quick romance does ...

IN October 1977, Lewis and Lewis presented data in the Journal on the health status of women in the United States. They wondered whether the fuller participation of women in the work force would alter their health, leading them to "die like men" as they ...

To the Editor: Two years ago, the Food and Drug Administration approved the use of the artificial sweetener aspartame (1-methyl N-L-alpha-aspartyl-L-phenylalanine) as a tabletop sugar substitute and additive in dry foods and beverage bases. At the time, ...

To the Editor: We recently encountered a child who had repeated episodes of meningococcal infection at 6 and 14 months of age. He was first seen in January 1982 because of fever and rash. Examination revealed an infant with an apparent severe infection, ...

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Nriagu (March 17 issue)¹ betrays a lack of awareness of the advances in historical research that have been made since Edward Gibbon wrote The Decline and Fall of the Roman Empire two centuries ago. Since that time the very idea of a "...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Since the publication of several studies establishing the safety and efficacy of high doses of intravenous metoclopramide for the control of cisplatin-induced emesis,^{1 2 3 4 5} the use of this treatment regimen has increased markedly. A ...

No extract is available for articles shorter than 400 words.

To the Editor: The rare microgranular variant of hypergranular acute promyelocytic leukemia may be morphologically confused with other types of acute nonlymphocytic leukemia.^{1 , 2} Although both forms are clinically similar and are associated with life-...

To the Editor: Recent articles in this and other journals have measured lymphocyte subpopulations by means of monoclonal antibodies. However, the authors usually have not stated how blood samples were stored before testing or for how long. We wish to ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: To our knowledge jaundice due to carbimazole therapy has been reported on only two previous occasions.^{1 , 2} In the case presented below, jaundice appeared immediately after an operation and reappeared on challenge with carbimazole.

In ...

To the Editory: After making an effort to ascertain whether an antibiotic prescribed for a patient with extreme lactose intolerance contained lactose as a "filler," I was most surprised to learn that pharmaceutical ingredients that are not classified as ...

The sheer volume of literature providing medical advice for the proverbial layperson is awesome. We pause to ask, Why?

The beginnings of popularized advice go back to medieval times, when the body gradually acquired a new distinction in Everyman's ...

The Department of Health and Human Services (DHHS) recently issued "Baby Doe II," a proposed rule designed to prevent hospitals from withholding food or medical care from handicapped infants. Born of a widely publicized incident in Bloomington, Indiana, ...