Hypercalcemia is frequently associated with malignant disease. Such hypercalcemia is due to an increase in bone resorption, but the pathogenesis of the increase is unknown in the majority of cases.¹ In patients with myeloma and other hematologic neoplasms,...

Previous studies of risk stratification after myocardial infarction have developed prognostic indexes from routine clinical features, such as historical data, vital signs, hemodynamic alterations in the coronary-care unit, enzyme levels, ...

Five to 10 per cent of all children will at some time have an illness with wheezing that is compatible with the diagnosis of asthma.^{1 , 2} Asthma is the most frequent of all the chronic illnesses of childhood.^{3 , 4} Despite recent major therapeutic advances,...

Protein C is the zymogen of a serine protease involved in blood coagulation.^{1 2 3 4} It is synthesized in the liver in the presence of sufficient amounts of vitamin K.¹ Protein C can be activated by thrombin,^{2 , 3 , 5} and this reaction is greatly ...

The positive effect of thiazides on calcium balance has been established.^{1 2 3 4 5 6 7} Condon et al.⁸ noted that thiazides improved calcium balance in osteoporotic subjects and in patients with steroid-induced osteoporosis, but the authors did not measure ...

For the past several years the American hospital industry has experienced a change with far-reaching consequences. What was essentially a cottage industry 20 years ago, dominated by the independent not-for-profit community hospital, is rapidly evolving ...

When the pharmacologic and clinical properties of the benzodiazepine sedative–anxioly tics were last reviewed comprehensively in 1973 and 1974,^{1 2 3} their use in clinical practice was very extensive and increasing.^{4 5 6} It was pointed out that a ...

Presentation of Case

A 31-year-old man was admitted to the hospital because of persistent fever and cranial-nerve defects.

He was well until eight months earlier, when fatigue, anorexia, and intermittent fever developed, followed by the onset of a cough; ...

One of the largest and most important parts of the "new medical-industrial complex"¹ is the proprietary-hospital industry, which now owns nearly 1100 hospitals in the United States, or about 15 per cent of all the general acute-care facilities in the ...

Staggering increases in the costs of providing hospital services have prompted a closer scrutiny of state cost-containment mechanisms. Two such mechanisms that exist in many state regulatory arsenals are rate-setting agencies and the determination-of-need ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Connors et al. (Feb. 3 issue)¹ reached the conclusion that the flow-directed right-heart catheter "yields information that results in a more accurate hemodynamic assessment" than a thorough clinical assessment does. Specifically, they ...

To the Editor: In their article on dilated cardiomyopathy of the adult, Johnson and Palacios review the pathophysiologic features and the causes of this poorly understood heart disease, emphasizing that "[n]o systematic study of ventricular arrhythmias ...

To the Editor: We would like to comment on the article "Late Cardiac Effects of Therapeutic Mediastinal Irradiation" by Gottdiener et al., which appeared in the March 10 issue.¹ Although provocative, this article is misleading and does not properly ...

No extract is available for articles shorter than 400 words.

To the Editor: Systems for sustained, long-term transcutaneous administration of drugs are becoming increasingly popular. The most widely used of these are for the delivery of nitroglycerin. These are available as Transderm Nitro (CIBA) and Nitro-Dur (...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

As the professional manager has gradually assumed the role of administrative leader in the nation's health facilities, it appears that a team of experts must assume the responsibility for constructing, or even revamping, a health facility. The three ...

Mr. Hagen presents us with a scholarly analysis of one of the more intriguing aspects of our health-care infrastructure. His book takes a global look at the blood and plasma industry, both commercial and not for profit. It therefore has special interest ...

One of the earliest major works in law and medicine (published first in 1960 and revised in 1970), this compilation of cases and related materials has helped to define its field. Now, with the publication of a refined and expanded third edition, it has ...

Of all the medical specialties, psychiatry, in the eyes of other specialty practitioners and perhaps even of many psychiatrists, is the one considered to be closest to the "art" pole of the art–science dichotomy.

The psychiatry-as-art view receives a ...

When I was asked to review this book, I considered whether my long personal and intellectual friendship with the author should disqualify me. I decided that it should not — first, because Fuchs works with statistical techniques, uses theories, and has ...

This is not a medical book, but one of political action. It declares that the healing profession has to face not only sickness in the individual but sickness in society; all too often, the second sickness is the root of the first.

The author, a political ...

If the number of book and magazine-story titles and the content of daytime television shows are any gauge, the public's appetite for learning about the personal lives of physicians is insatiable. About the only places where the personal lives of ...

SICKLE CELL DISEASE

A postgraduate conference entitled "Recent Advances in the Diagnosis and Management of Sickle Cell Disease" will be held at the Hyatt Regency–Capitol Hill in Washington, D.C., September 9–11. The fee is $150.

Contact Ms. Vera Ball, ...