Carcinoid tumors of the appendix and rectum are relatively frequent and usually benign neoplasms.¹ However, the small-bowel tumors more often have malignant attributes and are often associated with the carcinoid syndrome (flushing, diarrhea, and right-...

Since the initial description of it in 1963,¹ Reye's syndrome has been perceived as an illness generally associated with neurologic deterioration and death. This perception was reinforced during the influenza B epidemic of 1973–1974, when the Centers for ...

Tobacco advertisements claim that low-yield cigarettes "have" and deliver less tar and nicotine than higher-yield brands. Many physicians advise patients who cannot stop smoking to switch to low-tar, low-nicotine cigarettes, believing that they are safer. ...

It is generally accepted that DNA sequences represent the molecular basis of nuclear genes. Abnormalities in the base sequence of these nucleic acids are the controlling influence on the expression of inherited diseases mediated through alterations of ...

Bilirubin is generally thought to exist in three major forms in serum: as unconjugated bilirubin, as the monoglucuronide, or as the diglucuronide. The latter two subfractions give a "direct" reaction with standard diazo reagents, whereas unconjugated ...

Over the past 30 years, policy makers and third-party payers in the United States have been increasingly concerned with the rapid rise in the cost of hospital services. In documenting the rise in average cost per patient-day during this period, Feldstein ...

Diabetic ketoacidosis is a common illness among patients with diabetes. The exact prevalence is unknown, but in one community the rate was estimated to be 13.4 episodes per 1000 patient-years in young persons with diabetes.¹ It remains a serious event, ...

Presentation of Case

First admission. A 46-year-old man was admitted to the hospital because of a question of pericarditis.

There was a 17-year history of diabetes mellitus, treated in recent years with acetohexamide. The patient had taken ...

Twenty years ago, the seminal report by Reye et al. drew attention to "encephalopathy with fatty degeneration of the viscera."¹ This clinical entity, now recognized throughout the world, is a major cause of noninfectious neurologic death after viral ...

Is it hazardous to one's health to smoke, or is it not?

Basically, the debate between the tobacco industry and those who campaign against smoking has raged around this question since the first surgeon general's report on smoking and health was issued ...

Clinicians are now generally aware that mitochondria have a crucial role in the energy transformations of aerobic cells — a role that has been vividly captured in the designation "powerhouse of the cell." In this issue of the Journal, Egger and Wilson¹ ...

According to several recent reports,^{1 , 2} including that of Weiss et al. in this issue of the Journal,³ it now seems that there are not two, but three classes of bilirubin: free, conjugated, and covalently bound. The younger reader's eyes may glaze at the ...

Allen — Pliny Arunah Allen, M.D., of North Adams, died on May 4. He was 73.

Dr. Allen graduated from Harvard Medical School in 1934. He was a member of the American Medical Association, the American Society of Clinical Pathologists, the International ...

No extract is available for articles shorter than 400 words.

To the Editor: A recent paper by MacMahon et al. (Oct. 21 issue) reported a positive association between cigarette smoking and urinary estrogens.¹ Data suggesting that breast cancer was less frequent in smokers than in nonsmokers prompted their study. We ...

No extract is available for articles shorter than 400 words.

To the Editor: A report by Geller et al. presented preliminary results suggesting the possible usefulness of fenfluramine (a substituted phenylethylamine widely used as an appetite suppressant) in the treatment of infantile autism (July 15, 1982, issue).^...

To the Editor: Watson et al. recently reported a case of polymyositis induced by cimetidine, a drug with a possible role as an immunomodulator (Jan. 20 issue).¹ Since November 1982, we have had the opportunity to follow the patient described in their ...

No extract is available for articles shorter than 400 words.

To the Editor: The report by Castro and Haddy in the March 3 issue¹ suggests that concomitant iron deficiency increases the life span of red cells in homozygous sickle-cell disease by inhibiting intravascular sickling and reducing the hemolytic rate. We ...

To the Editor: The erythrocyte is the sole human cell for which the intracellular lithium concentration during lithium therapy for manic-depressive illness is known. Estimates of lithium concentrations in human excitable cells would be important, since ...

To the Editor: Judzewitsch et al. (Jan. 20 issue)¹ documented small changes in nerve conduction velocity during sorbinil therapy of diabetic patients, but the techniques they used were antiquated and relatively inaccurate; variations of several meters ...

To the Editor: Dr. Roll and his colleagues are to be congratulated on their long-term study of the natural history of primary biliary cirrhosis (Jan. 6 issue).* If their data are representative, they offer good news for patients with the disease, for at ...

No extract is available for articles shorter than 400 words.

To the Editor: Several recent articles in the Journal (Feb. 25 and Aug. 26, 1982, issues)^{1 , 2} and elsewhere^{3 4 5 6} have considered aspects of physician stress. Our unique role in the lives of our fellow human beings places us in one of the most ...

Not many medical discoveries have had the impact of the birth-control pill, our first "social medication." It brought within its focus the requirements of our drug-regulatory agencies, the difficulties of assessing benefit-task ratios when welfare and ...

No extract is available for articles shorter than 400 words.

Although both these books are about women and their diseases, they aim at rather different audiences.

Everywoman has been written for the laywoman to help her gain more knowledge about her body and how it functions. It is easy to read, thorough, factual, ...

At first glance these two books are quite different and perhaps appeal to different groups of the many physicians who look after adolescents. And yet, the closer they are examined, the more they complement each other, and they should be read for different ...

No extract is available for articles shorter than 400 words.

THE LAW AND TECHNOLOGY RESOURCE CENTER

The Franklin Pierce Law Center has established the Law and Technology Resource Center in Concord, N.H., to provide members with a means of anticipating and planning for legal developments arising in response to ...