AN association between psychological characteristics, such as anxiety and depression, and symptoms typifying esophageal motility disorders has been suggested in the literature.^{1 2 3} However, it has not been studied systematically in relation to any of the ...

The presence of estrogen receptors in breast cancers is now accepted as a predictor of extended disease-free survival, but the relative value of progesterone receptors for this purpose has not been established. We have examined both receptors along with ...

THE treatment of acute nonlymphocytic leukemia with high-dose chemotherapy and total-body irradiation followed by allogeneic bone-marrow transplantation has been attempted by a number of centers. Therapeutic results have been encouraging, especially when ...

DEATH rates for coronary heart disease in the United States fell 20.7 per cent between 1968 and 1978 among adults 30 to 74 years old.¹ This dramatic change is now the subject of research to differentiate trends in in-hospital and out-of-hospital sites of ...

CONTROLLED clinical trials employ a variety of methods for assigning treatment. It has been broadly accepted that randomization is the best method for obtaining comparability of groups in a clinical trial. Some have raised ethical objections to ...

THE spectrum of common contagious diseases of childhood in the United States has changed dramatically over the past 25 years. After cultivation of the viruses causing poliomyelitis, rubella, and mumps, effective vaccines rapidly became available. ...

OVER the past six years the treatment of peptic-ulcer disease has been dramatically altered by the introduction and use of cimetidine. This substituted imidazole compound is an effective H₂-receptor antagonist, which acts on the gastric parietal cell to ...

Presentation of Case

A 14-year-old boy was admitted to the hospital because of recurrent hemoptysis.

He was well and active until six months earlier, when he began to cough up flecks of blood that progressed to frank hemoptysis. At about the same time he ...

The increasing complexity of scientific knowledge and investigative techniques has fostered a tendency for research to focus on smaller and smaller components because compartmentalization makes the task more manageable. Unfortunately, this trend has ...

The hormone dependency of human breast cancer has been known since 1896, when Beatson¹ reported regression of inoperable primary tumors after ovariectomy in two premenopausal women. It is now well established that approximately one third of human breast ...

Bone-marrow transplantation has become an important treatment for a number of diseases, and it also offers a unique model in which the effects of drugs on hematopoietic stem cells can be evaluated. In addition, the origins and life span of ...

To the Editor: The recent report of Isenberg et al.¹ and the editorial in the same issue (June 2)² did not include several important aspects of cimetidine treatment. Compliance was not measured; more than 10 per cent of the enrolled subjects dropped out ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: I wish to describe a family unusual for the predisposition of its members to the development of tumors of the testis or gynecologic system. This family, of Spanish-American origin, first came to my attention when one of its members, a 22-...

To the Editor: We have treated a patient with Hodgkin's disease and the nephrotic syndrome, a combination similar to that reported in Case 15–1983 (April 14 issue).* A previously fit 19-year-old white man noted swelling of his face and limbs for two ...

To the Editor: The report by Reid et al. (June 2 issue)¹ on a cytogenetic analysis of single colonies (CFU-C) grown in culture from the bone marrow of a patient with acute myelomonocytic leukemia in partial remission indicates that part of the colonies ...

To the Editor: Because of the patient population selected for the study by Heaf et al. (June 23 issue),¹ their conclusion must be interpreted with caution. Eight of the 10 patients with "unilateral" lung disease had undergone prior repair of congenital ...

To the Editor: The report of Baxi et al. (June 23 issue) demonstrates the advantages of prenatal diagnosis in managing intestinal malformations.¹ Our experience managing intestinal malformations in 12 fetuses, including 2 with perforation and pseudocyst ...

No extract is available for articles shorter than 400 words.

To the Editor: Unlike Gleckman and Williams (Feb. 24 issue),¹ we remain unconvinced by the arguments of Stamm and his colleagues (Aug. 19, 1982, issue)² that the best diagnostic criterion of coliform urinary infection in symptomatic women is the presence ...

To the Editor: The discovery by Arthur and Bloomfield¹ of an association between a partial deletion of chromosome 16 and bone-marrow eosinophilia in acute nonlymphocytic leukemia appears to be another example of the growing number of specific human ...

To the Editor:. . . In their discussion of the California plan in the March 31 issue,* Melia and colleagues raise the possibility of an outcome they describe as follows: To ensure quality while controlling costs, physician groups will develop diagnostic ...

To the Editor: The current epidemic of the acquired immunodeficiency syndrome (AIDS) has attracted tremendous attention in the scientific and lay literature and has demonstrated vividly the direct and ripple effects of the private activities of society's ...

No extract is available for articles shorter than 400 words.

Treatment strategies in infectious diseases stimulate the production of "pocket size" prescribing aids. A perusal of residents' and students' coat pockets will reveal a dazzling array of small paperbacks, all designed to remove thinking from antibiotic ...

This book contains current in-depth reviews and critical commentaries, which can be divided arbitrarily into four general categories. One covers specific aspects of antiinfective agents, including the newer aminoglycoside antibiotics and the most recently ...

These two books provide the nonspecialist with an approach to major problems in infectious diseases.

The stated goal of the first book (Practical Infectious Diseases) is to familiarize the reader with "innovations in the diagnosis and management of some ...

This book provides medical and social information about herpes infections, centering around the venereal transmission of the disease. In the past three years there has been a tremendous increase in the public awareness of diseases that are transmitted ...

In the preface to this astonishing book, the editor states that the original outline was "scribbled" on the Dover–Calais ferry. This may, just possibly, be true. The scope of this work is so extensive that, if a substantial portion was indeed mapped out ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In 1974, Polano and Suurmond published 150 color photographs from the archives of the University Medical Center in Leiden. To these they appended brief comments in Dutch. The quality of the photographs and the color plates was outstanding. Until now they ...

No extract is available for articles shorter than 400 words.

CALL FOR PAPERS

Abstracts are now being accepted for the First International Conference on Environmental Contamination. The conference will be held in London, England, July 10–13.

Contact CEP Consultants, 26 Albany St., Edinburgh EH1 3QH, England; or call ...

IN June 1979, an article in the Journal ¹ described a new type of independent practice association (IPA), which was designed to encourage primary-care physicians in private practice to become coordinators and financial managers of medical care for their ...