CHILDREN of mothers with phenylketonuria often have mental retardation, microcephaly, congenital heart disease, and low birth weight.^{1 2 3 4} Offspring with phenylketonuria and those without it are similarly affected.² Spontaneous abortion has also been ...

THE importance of accurately diagnosing non-Hodgkin's lymphoma has increased in recent years as a result of advances in the staging and treatment of these disorders. However, a variety of different nonlymphoid neoplasms may, on occasion, show histologic ...

THE hypothesis has been advanced that in utero exposure to diazepam, a benzodiazepine drug, increases the risk of cleft lip or cleft palate in the exposed infant. In 1975, Saxén and Saxén^{1 , 2} found that exposure to benzodiazepines (mainly diazepam) ...

IN the child with precocious puberty in the absence of a correctable anatomic lesion, the goal of therapy is suppression of gonadal function in order to arrest or reverse secondary sexual development, decrease the linear growth rate to a normal ...

Clinical trials of medical treatments often compare two or more groups of patients treated separately but concurrently as part of the same study. We call these trials "parallel" to emphasize their difference from other clinical trials in which patients ...

WE define acute glomerulonephritis as the sudden appearance of hematuria, proteinuria, and red-cell casts. The last finding, which rarely occurs in other types of renal disease,¹ is virtually diagnostic of active glomerular inflammation. The clinician ...

SUDDEN cardiac death accounts for approximately two thirds of the 600,000 annual deaths that are attributable to cardiac disease in the United States. Most of these deaths are instantaneous, occurring within seconds or minutes, and where documented, the ...

Presentation of Case

A 7 1/2-year-old girl was admitted to the hospital because of diarrhea and arthralgia.

She was well until five months previously, when dysuria developed and evidence of a urinary-tract infection was found. Ampicillin was administered, ...

Hospitals all over the country are organizing new corporations to spin off traditional services and initiate new activities, and then joining or competing with doctors and other hospitals in new ventures such as health-maintenance organizations, preferred-...

Part of the current debate on health-care delivery involves whether or not the investor-owned health-care industry is providing a needed service to the American people. The questions most frequently raised relate to studies about such issues as the ...

Thoughtful observers worry these days that the competitive model commercial interests are introducing into medical care will compromise the quality of care that has been upheld by the medical profession during this century.^{1 , 2} Yet the relations between ...

The use of sophisticated medical technology has made it possible for increasing numbers of children to survive the acute effects of extreme prematurity, neurologic diseases, severe trauma, and congenital abnormalities. Some of these children, including ...

To the Editor: The defect in cellular immunity primarily affecting the male homosexual population and associated with opportunistic systemic infections and Kaposi's sarcoma is currently the subject of intense medical interest.¹ Many of these patients ...

No extract is available for articles shorter than 400 words.

To the Editor: Drs. Blum and Ruoff (July 14 issue) describe a nondiabetic patient taking propylthiouracil for thyrotoxicosis and also taking 15 mg of propranolol four times a day, in whom serious reactive hypoglycemia — with a plasma glucose level of 17 ...

No extract is available for articles shorter than 400 words.

To the Editor: Abnormalities in the monoamine systems of patients with behavior disorders (e.g., autism, schizophrenia) continue to be investigated for a potential etiologic role. Evidence has been advanced that children with hyperactivity (now referred ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This is one of a growing number of recent short books on gastroenterology aimed principally at medical students, house officers, and primary-care physicians. In this case, the stated goal of the authors was "to provide a readable and clearly stated, yet ...

A spate of articles and books on "functional" gastrointestinal disorders have been published in recent years. Yet there is a need for something more than just a scholarly review of this subject. At the same time, the behavioral sciences have developed ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

There appears to be a national hunger for information on nutrition. This is understandable. Epidemiologic data seem to implicate dietary factors in conditions such as coronary-artery disease and colonic cancer. Malnutrition is in evidence in chronically ...

Of the several weight-loss diets advocated as "the answer" for achieving the perfect body, only a disappointing few are based on physiologic fact and common sense. It is a pleasant surprise, therefore, to read two diet books that offer sound, safe diet ...

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ORGAN TRANSPLANTATION

The Human Resource Selection Network is establishing a computer-based system for matching organ donors and recipients. It is available locally, nationally, and internationally either on a direct-dial method, or through TYMNET or ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Today's proliferation of highly technical and expensive methods of treating patients with chronic diseases led officials of the Arthritis Foundation and National Multiple Sclerosis Society to sponsor a workshop exploring methods of payment for clinical ...